Skip to main content

Modified Fractionated Radiotherapy in Head and Neck Squamous Cell Carcinoma (HNSCC) & Re-Irradiation in Recurrent Head and Neck Carcinomas

  • Chapter
Head and Neck Cancer

Part of the book series: Cancer Treatment and Research ((CTAR,volume 114))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Sanchiz F., Milla A., Torner J., et al. Single fraction versus two fractions per day versus radio-chemotherapy in the treatment of HNSCC. Int. J. Radiat. Oncol. Biol. Phys. 1990; 19: 1347–50.

    PubMed  CAS  Google Scholar 

  2. Marcial V.A., Pajak T.F., Chang C. et al. Hyperfractionated photon radiation therapy in the treatment of advanced squamous cell carcinoma of the oral cavity, pharynx, larynx, and sinuses, using radiation therapy as the only planned modality: (preliminary report) by the Radiation Therapy Oncology Group (RTOG). Int. J. Radiat. Oncol. Biol. Phys. 1987;13: 41–47.

    PubMed  CAS  Google Scholar 

  3. Horiot JC, LeFur R, N’ Guyen T et al. Hyperfractionation versus conventional fractionation in oropharyngeal carcinoma: final analysis of a randomized trial of the EORTC cooperative group of radiotherapy. Radiother Oncol 1992; 25: 231–241.

    PubMed  CAS  Google Scholar 

  4. Datta N.R., Dutta Choudhry A., Gupta S, Bose A.K., Twice a day versus once a day radiation therapy in head and neck cancer. Int. J. Radiat. Oncol. Biol. Phys. 1989; 17(suppl 1): 132.

    Google Scholar 

  5. Pinto L.H.J., Canary P.C.V., Araujo C.M.M. et al. Prospective randomized trial comparing hyperfractionated versus conventional radiotherapy in stage III and IV oropharyngeal carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 1991;21: 557–562.

    PubMed  CAS  Google Scholar 

  6. Cummings B, O’Sullivan B, Keane T et al. 5-year results of 4 week/twice daily radiation schedule—The Toronto Trial. Rad. Oncol. 2000; 56(suppl. 1): S8.

    Google Scholar 

  7. Fu KK, Pajak TF, Trotti A, et al. A radiation therapy oncology group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: first report ofRTOG 9003. Int J Rad Oncol Biol Phys 2000, 48: 7–16.

    CAS  Google Scholar 

  8. Olmi P, Fallai C, Rossi F, Crispino S, Marsoni S, Torri V, Flann M. Conventional radiotherapy versus accelerated hyperfractionated radiotherapy versus conventional radiotherapy and concomitant chemotherapy in advanced oropharyngeal carcinoma: a randomized clinical trial. Proc. 4th International Conference on Head and Neck Cancer 1996: 213.

    Google Scholar 

  9. Horiot JC, Bontemps P., van den Bogaert W. et al. Accelerated fractionation (AF) compared to conventional fractionation (CF) improves loco-regional control in the radiotherapy of advanced head and neck cancer: results of the EORTC 22851 randomized trial. Rad Oncol 1997;44: 111–121.

    CAS  Google Scholar 

  10. Bernier J Horiot JC Van den Bogaert et al. EORTC update of the head and neck cancer altered fractionation phase III trials. Rad. Oncol. 2000; 56suppl. 1 S8.

    Google Scholar 

  11. Dische S, Saunders M, Barrett A, et al. A randomized multicentre trial of CHART vs conventional radiotherapy in head and neck cancer. Rad Oncol 1997;44: 123–136.

    CAS  Google Scholar 

  12. Jackson SM, Weir LM, Hay JH, Tsang VHY, Durham JS. A randomized trial of accelerated versus conventional radiotherapy in head and neck cancer. Rad. Oncol. 1997;43:39–46.

    CAS  Google Scholar 

  13. Ang KK, Trotti A, Garden AS, et al. Impact of risk factors and total time for combined surgery and radiotherapy on the outcome of patients with advanced head and neck cancer. Int J Rad Oncol Biol Phys 1999, 45(suppl. 3): 199.

    Google Scholar 

  14. Grau C, Overgaard J, Hansen H et al. Acute and late normal tissue reactions following accelerated radiotherapy for head and neck cancer. Results from DAHANCA-7. Rad. Oncol. 2000; 56(suppl. 1): S12.

    Google Scholar 

  15. Dobrowsky W, Naudé J. Continuous hyperfractionated accelerated radiotherapy with/without mitomycin C in head and neck cancer. Rad Oncol 2000;57:119–124.

    CAS  Google Scholar 

  16. Bourhis J, Lapeyre M, Rives M, Tortochaux J, Bourdin S, Lasaulnier F, et al. Very accelerated radiotherapy in HNSCC: results of the GORTEC 94-02 randomized trial. Proc Am Soc Clin Oncol 2000;19:412a.

    Google Scholar 

  17. Skaladowski K, Maciejewski B, Golen M, et al. Randomized clinical trial on 7-days continuous accelerated irradiation (CAIR) of head and neck cancer-report on 3-year tumor control and normal tissue toxicity. Rad. Oncol. 2000; 55: 101–110.

    Google Scholar 

  18. Denham J, Poulsen M, Lamb DS et al. The TROG 91.01 randomised controlled trial addressing the question of accelerated fractionation. Rad. Oncol. 2000; 56(suppl. 1): S7.

    Google Scholar 

  19. Tandon N, Keshwar TS, Srivastava M, et al. Continuous hyperfractionated accelerated radiotherapy (CHART) in head and neck malignancies. XVth Asia Pacific Cancer Conference, December 1999, Chennai. Proceeding of XVth Asia Pacific Cancer Conference: 90.

    Google Scholar 

  20. Hliniak A, Gwiazdowska B, Szutkowski Z, et al. Radiotherapy of the laryngeal cancer. The estimation of the therapeutic gain and the enhancement of toxicity by the one-week shortening of the treatment time. Results of the randomized phase III multicenter trial. Rad Oncol 2000; 56(suppl. 1): S5.

    Google Scholar 

  21. Lippman SM, Hong WK: Second malignant tumors in head and neck squamous cell carcinoma: the overshadowing threat for patients with early-stage disease. Int J Radiat Oncol Biol Phys 1989; 17:691–694.

    PubMed  CAS  Google Scholar 

  22. Hong WK, Bromer R: Chemotherapy in head and neck cancer. N Engl J Med 1983; 308:75–79.

    Article  PubMed  CAS  Google Scholar 

  23. Liggett WJ, Forastiere AA: Chemotherapy advances in head and neck oncology. Semin Surg Oncol 1995; 11:265–271.

    PubMed  Google Scholar 

  24. Puthawala AA, Syed AM: Interstitial re-irradiation for recurrent and/or persistent head and neck cancers. Int J Radiat Oncol Biol Phys 1987; 13:1113–1114.

    PubMed  CAS  Google Scholar 

  25. Mazeron JJ, Langlois D, Glaubiger D, et al: Salvage irradiation of oropharyngeal cancers using iridium 192 wire implants: 5-year results of 70 cases. Int J Radiat Oncol Biol Phys 1987; 13:957–962.

    PubMed  CAS  Google Scholar 

  26. Housset M, Barrett JM, Brunel P, et al: Split course interstitial brachytherapy with a source shift: the results of a new technique for salvage irradiation in recurrent inoperable cervical lymphadenopathy greater than or equal to 4 cm diameter in 23 patients. Int J Radiat Oncol Biol Phys 1992; 22:1071–1074.

    PubMed  CAS  Google Scholar 

  27. Levendag PC, Meeuwis CA, Visser AG: Reirradiation of recurrent head and neck cancers: external and/or interstitial radiation therapy. Radiother Oncol 1992; 23:6–15.

    Article  PubMed  CAS  Google Scholar 

  28. Lee DJ, Liberman FZ, Park RI, et al: Intraoperative 1-125 seed implantation for extensive recurrent head and neck carcinomas. Radiology 1991; 178:879–882.

    PubMed  CAS  Google Scholar 

  29. Maulard C, Housset M, Delanian S, et al: Salvage spilt course brachytherapy for tonsil and soft palate carcinoma: treatment techniques and results. Laryngoscope 1994; 104:359–363.

    PubMed  CAS  Google Scholar 

  30. Langlois D, Hoffstetter S, Pernot M: Selection of patients for re-irradiation with local implants in carcinomas of oropharynx and tongue. Acta Oncol 1988; 27:571–573.

    Article  PubMed  CAS  Google Scholar 

  31. Fontanesi J, Hetzler D, Ross J: Effect of dose rate on local control and complications in the reirradiation of head and neck tumors with interstitial iridium-192. Int J Radiat Oncol Biol Phys 1989; 17:365–369.

    PubMed  CAS  Google Scholar 

  32. Mazeron JJ: Interstitial re-irradiation for recurrent and/or persistent head and neck cancers. Int J Radiat Oncol Biol Phys 1987; 13:1261

    PubMed  CAS  Google Scholar 

  33. Kwong DL, Wei WI, Cheng AC, et al: Long term results of radioactive gold grain implantation for the treatment of persistent and recurrent nasopharyngeal carcinoma. Cancer 2001; 91:1105–1113.

    Article  PubMed  CAS  Google Scholar 

  34. Lee AW, Foo W, Law SC, et al: Reirradiation for recurrent nasopharyngeal carcinoma: factors affecting the therapeutic ratio and ways for improvement. Int J Radiat Oncol Biol Phys 1997; 38:43–52.

    PubMed  CAS  Google Scholar 

  35. Peiffert D, Pernot M, Malissard L, et al: Salvage irradiation by brachytherapy of velotonsillar squamous cell carcinoma in a previously irradiated field: results in 73 cases. Int J Radiat Oncol Biol Phys 1994; 29:681–686.

    PubMed  CAS  Google Scholar 

  36. Leung TW, Tung SY, Sze WK, et al: Salvage radiation therapy for locally recurrent nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 2000; 48:1331–1338.

    Article  PubMed  CAS  Google Scholar 

  37. Haraf DJ, Vokes EE, Weichselbaum RR, et al: Concomitant chemoradiotherapy with cisplatin, 5-fluorouracil and hydroxyurea in poor-prognosis head and neck cancer. Laryngoscope 1992; 102:630–636.

    PubMed  CAS  Google Scholar 

  38. Schaefer U, Micke O, Schueller P, et al: Recurrent head and neck cancer: retreatment of previously irradiated areas with combined chemotherapy and radiation therapy-results of a prospective study. Radiology 2000; 216:371–376.

    PubMed  CAS  Google Scholar 

  39. Teo PM, Kwan WH, Chan AT, et al: How successful is high-dose (> or = 60 Gy) reirradiation using mainly external beams in salvaging local failures of nasopharyngeal carcinoma? Int J Radiat Oncol Biol Phys 1998; 40:897–913.

    Article  PubMed  CAS  Google Scholar 

  40. Hwang JM, Fu KK, Phillips TL: Results and prognostic factors in the retreatment of locally recurrent nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 1998; 41:1099–1111.

    Article  PubMed  CAS  Google Scholar 

  41. Gandia D, Wibault P, Guillot T, et al: Simultaneous chemoradiotherapy as salvage treatment in locoregional recurrences of squamous head and neck cancer. Head Neck 1993; 15:8–15.

    PubMed  CAS  Google Scholar 

  42. Benchalal M, Bachaud JM, Francois P, et al: Hyperfractionation in the reirradiation of head and neck cancers. Result of a pilot study. Radiother Oncol 1995; 36:203–210.

    Article  PubMed  CAS  Google Scholar 

  43. De Crevoisier R, Bourhis J, Domenge C, et al: Full-dose reirradiation for unresectable head and neck carcinoma: experience at the Gustave-Roussy Institute in a series of 169 patients. J Clin Oncol 1998; 16:3556–3562.

    PubMed  Google Scholar 

  44. De Crevoisier R, Domenge C, Wibault P, et al: Full dose reirradiation combined with chemotherapy after salvage surgery in head and neck carcinoma. Cancer 2001; 91:2071–2076.

    PubMed  Google Scholar 

  45. McNeese MD, Fletcher GH: Retreatment of recurrent nasopharyngeal carcinoma. Radiology 1981; 138:191–193.

    PubMed  CAS  Google Scholar 

  46. Wang CC: Radical re-irradiation for carcinoma arising from the previously irradiated larynx. Laryngoscope 1967; 77:2189–2195.

    PubMed  CAS  Google Scholar 

  47. Wang CC: Re-irradiation of recurrent nasopharyngeal carcinoma—treatment techniques and results. Int J Radiat Oncol Biol Phys 1987; 13:953–956.

    PubMed  CAS  Google Scholar 

  48. Wang CC, McIntyre J: Re-irradiation of laryngeal carcinoma—techniques and results. Int J Radiat Oncol Biol Phys 1993; 26:783–785.

    PubMed  CAS  Google Scholar 

  49. Langlois D, Eschwege F, Kramar A, et al: Reirradiation of head and neck cancers. Presentation of 35 cases treated at the Gustave Roussy Institute. Radiother Oncol 1985; 3:27–33.

    PubMed  CAS  Google Scholar 

  50. Tercilla OF, Schmidt-Ullrich R, Wazer DE: Reirradiation of head and neck neoplasms using twice-a-day scheduling. Strahlenther Onkol 1993; 169:285–290.

    PubMed  CAS  Google Scholar 

  51. Pomp J, Levendag PC, van Putten WL: Reirradiation of recurrent tumors in the head and neck. Am J Clin Oncol 1988; 11:543–549.

    PubMed  CAS  Google Scholar 

  52. Stevens KR, Britsch A, Moss WT: High-dose reirradiation of head and neck cancer with curative intent. Int J Radiat Oncol Biol Phys 1994; 29:687–698.

    PubMed  Google Scholar 

  53. Yan JH, Hu YH, Gu XZ: Radiation therapy of recurrent nasopharyngeal carcinoma. Report on 219 patients. Acta Radiol Oncol 1983; 22:23–28.

    PubMed  CAS  Google Scholar 

  54. Skolyszewski J, Korzeniowski S, Reinfuss M: The reirradiation of recurrences of head and neck cancer, Br J Radiol 1980; 53:462–465.

    PubMed  CAS  Google Scholar 

  55. Orecchia R, Airoldi M, Sola B, et al: Results of chemotherapy plus external reirradiation in the treatment of locally advanced recurrences of nasopharyngeal carcinoma. Eur J Cancer B Oral Oncol 1992; 28B:109–111.

    PubMed  CAS  Google Scholar 

  56. Weppelmann B, Wheeler RH, Peters GE, et al: Treatment of recurrent head and neck cancer with 5-fluorouracil, hydroxyurea, and reirradiation. Int J Radiat Oncol Biol Phys 1992; 22:1051–1056.

    PubMed  CAS  Google Scholar 

  57. Emami B, Bignardi M, Spector GJ, et al: Reirradiation of recurrent head and neck cancers. Laryngoscope 1987; 97:85–88.

    PubMed  CAS  Google Scholar 

  58. Lee AW, Law SC, Foo W, et al: Retrospective analysis of patients with nasopharyngeal carcinoma treated during 1976–1985: survival after local recurrence. Int J Radiat Oncol Biol Phys 1993; 26:773–782.

    PubMed  CAS  Google Scholar 

  59. Pryzant RM, Wendt CD, Delclos L, et al: Re-treatment of nasopharyngeal carcinoma in 53 patients. Int J Radiat Oncol Biol Phys 1992; 22:941–947.

    PubMed  CAS  Google Scholar 

  60. Haraf DJ, Vokes EE, Panje WR, et al: Survival and analysis of failure following hydroxyurea, 5-fluorouracil and concomitant radiation therapy in poor prognosis head and neck cancer. Am J Clin Oncol 1991; 14:419–426.

    PubMed  CAS  Google Scholar 

  61. Haraf DJ, Weichselbaum RR, Vokes EE: Re-irradiation with concomitant chemotherapy of unresectable recurrent head and neck cancer: a potentially curable disease. Ann Oncol 1996; 7:913–918.

    PubMed  CAS  Google Scholar 

  62. Cho JH, Kim GE, Cho KH, et al: Hyperfractionated re-irradiation using a 3-dimensional conformal technique for locally recurrent carcinoma of the nasopharynx; preliminary results. Yonsei Med J 2001; 42:55–64.

    PubMed  CAS  Google Scholar 

  63. Brockstein B, Haraf DJ, Stenson K, et al: A phase I-II study of concomitant chemoradiotherapy with paclitaxel (one-hour infusion), 5-fluorouracil and hydroxyurea with granulocyte colony stimulating factor support for patients with poor prognosis head and neck cancer. Ann Oncol 2000; 11:721–728.

    Article  PubMed  CAS  Google Scholar 

  64. Wang CC: Decision making for re-irradiation of nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 1993; 26:903

    PubMed  CAS  Google Scholar 

  65. Firlik KS, Kondziolka D, Lunsford LD, et al: Radiosurgery for recurrent cranial base cancer arising from the head and neck. Head Neck 1996; 18:160–165.

    Article  PubMed  CAS  Google Scholar 

  66. Chua DT, Sham JS, Hung KN, et al: Stereotactic radiosurgery as a salvage treatment for locally persistent and recurrent nasopharyngeal carcinoma. Head Neck 1999; 21:620–626.

    Article  PubMed  CAS  Google Scholar 

  67. Buatti JM, Friedman WA, Bova FJ, et al: Linac radiosurgery for locally recurrent nasopharyngeal carcinoma: rationale and technique. Head Neck 1995; 17:14–19.

    PubMed  CAS  Google Scholar 

  68. Miller RC, Foote RL, Coffey RJ, et al: The role of Stereotactic radiosurgery in the treatment of malignant skull base tumors. Int J Radiat Oncol Biol Phys 1997; 39:977–981.

    PubMed  CAS  Google Scholar 

  69. Cmelak AJ, Cox RS, Adler JR, et al: Radiosurgery for skull base malignancies and nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 1997; 37:997–1003.

    Article  PubMed  CAS  Google Scholar 

  70. Ahn YC, Kim DY, Huh SJ, et al: Fractionated stereotactic radiation therapy for locally recurrent nasopharynx cancer: report of three cases. Head Neck 1999; 21:338–345.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Kluwer Academic Publishers

About this chapter

Cite this chapter

De Crevoisier, R.M.D., Bourhis, J., Eschwéege, F.M.D. (2004). Modified Fractionated Radiotherapy in Head and Neck Squamous Cell Carcinoma (HNSCC) & Re-Irradiation in Recurrent Head and Neck Carcinomas. In: Bruce, B., Gregory, M. (eds) Head and Neck Cancer. Cancer Treatment and Research, vol 114. Springer, Boston, MA. https://doi.org/10.1007/0-306-48060-3_7

Download citation

  • DOI: https://doi.org/10.1007/0-306-48060-3_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4020-7336-6

  • Online ISBN: 978-0-306-48060-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics