Regular ArticleActivation of NF-κB in Normal Rat Kidney Epithelial (NRK52E) Cells Is Mediated via a Redox-Insensitive, Calcium-Dependent Pathway
References (57)
- et al.
NF-κB and transcriptional control of renal epithelial-inducible nitric oxide synthase
Kidney Int.
(1995) - et al.
NF-κB: Ten years after
Cell
(1996) - et al.
Effects of oxidants and antioxidant on nuclear factor κB activation in three different cell lines: Evidence against a universal hypothesis involving oxygen radicals
Biochim. Biophys. Acta
(1995) - et al.
Activation of NF- κB by antineoplastic agents. Role of protein kinase C
J. Biol. Chem.
(1997) - et al.
Redox regulation of NF-Kappa B activation
Free Radical Biol. Med.
(1997) NF-κB, KBF1, dorsal, andrel
Cell
(1990)- et al.
Optimal NFκB mediated transcriptional responses in Jurkat T cells exposed to oxidative stress are dependent on intracellular glutathione and costimulatory signals
Biochem. Biophys. Res. Commun.
(1996) - et al.
Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (Sn
J. Biol. Chem.
(1979) - et al.
Thapsigargin, a high affinity and global inhibitor of intracellular Ca2+
Arch. Biochem. Biophys.
(1992) - et al.
The role of mitochondrial glutathione and cellular protein sulfhydryls in formaldehyde toxicity in glutathione-depleted rat hepatocytes
Arch. Biochem. Biophys.
(1986)
Rel/NF-κB and IκB factors in oncogenesis
Cancer Biol.
(1997)
Status of the mitochondrial pool of glutathione in the isolated hepatocyte
J. Biol. Chem.
(1982)
Nuclear factor kappa B, a mediator of lipopolysaccharide effects
Immunobiology
(1993)
Hydrogen peroxide and ischemic renal injury: Effect of catalase inhibition
Free Radical Biol. Med.
(1991)
Suppression of NF-κB and AP-1 activation by glucocorticoids in experimental glomerulonephritis in rats: Modulation of mechanisms of anti-nephritic action
Biochim. Biophys. Acta
(1997)
Reactive oxygen intermediates activate NF-κB in a tyrosine kinase-dependent mechanism and in combination with vanadate activate the p56lkcfyn
Blood
(1993)
Involvement of intracellular Ca2+
FEBS Lett.
(1996)
Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
Cell
(1995)
Enhancement of γ-glutamylcysteine synthetase mRNA in rat kidney by methylmercury
Arch. Biochem. Biophys.
(1992)
Role of transcription factor NF-κB/Rel in induction of nitric oxide synthetase
J. Biol. Chem.
(1994)
IκB: a specific inhibitor of the NF-κB transcription factor
Science (Washington, D.C.)
(1988)
Function and activation of NF-κB in the immune system
Annu. Rev. Immunol.
(1994)
Flow cytometric studies of oxidative product formation by neutrophils: A graded response to membrane stimulation
J. Immunol.
(1983)
Inhibition of NF-κB activity induces apoptosis in murine hepatocytes
Am. J. Pathol.
(1997)
A role for transcription factor NF-κB in inflammation
Inflam. Res.
(1997)
Differential mechanisms of LPS-induced NF-κB activation in macrophages and fibroblasts
J. Endotox. Res.
(1996)
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
Nucleic Acid Res.
(1983)
Constitutive nuclear NF-κB in cells of monocyte lineage
Biochem. J.
(1994)
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2018, Life SciencesCitation Excerpt :These features may explain the reduced oxidative stress we observed. Nevertheless, in vitro evidence demonstrates that PDTC, but not the antioxidant molecule N-acetylcysteine, reduces LPS-induced NF-κB activation in tubular epithelial cells [62] suggesting that in this cell type, the effect of PDTC on NF-κB may depend on the ability to inhibit NF-κB activation rather than its antioxidant activity. In this work, the challenge with a toxic dose of diclofenac induced classical clinical signs of AKI in mice, notably increased proteinuria, urine NGAL levels, and plasma levels of urea, creatinine, oxidative stress and pro-inflammatory markers (e.g. CRP, TNF-α and IL-6).
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