Regular ArticleTHE PROTECTIVE ACTION OF THYMOL AGAINST CARBON TETRACHLORIDE HEPATOTOXICITY IN MICE☆
References (18)
- et al.
Oxygen- and carbon-centred free radical formation during carbon tetrachloride metabolism: observation of lipid radicals in vivo and in vitro
J Biol Chem
(1984) - et al.
Mechanism for the protective effects of silymarin against carbon tetrachloride-induced lipid peroxidation and hepatotoxicity in mice: evidence that silymarin acts both as an inhibitor of metabolic activation and as a chain-breaking antioxidant
Biochem Pharmacol
(1990) - et al.
The crucial antioxidant action of schisandrin B in protecting against carbon tetrachloride hepatotoxicity in mice: a comparative study with butylated hydroxytoluene
Biochem Pharmacol
(1996) - et al.
An tioxidant actions of thymol, carvacrol, 6-gingerol, zinzerone and hydroxytyrosol
Food Chem Toxicol
(1994) - et al.
Determination of malonaldehyde precursor in tissues by thiobarbituric acid test
Anal Biochem
(1978) - et al.
Effects of disulfiram on hepatic P-450 2E1, other microsomal enzymes, and hepatotoxicity in rats
Toxicol Appl Pharmacol
(1991) - et al.
Induction of metallothionein synthesis by menadione or carbon tetrachloride is independent of free radical production
Toxicol Appl Pharmacol
(1992) - et al.
Mechanism of carbon tetrachloride toxicity
Pharmacol Ther
(1989)
Cited by (56)
Thymol ameliorates ethanol-induced hepatotoxicity via regulating metabolism and autophagy
2023, Chemico-Biological InteractionsCitation Excerpt :Pharmacological properties of thymol such as antioxidant and anti-inflammatory facilitate its use in the medical field [7]. Previous study reported the preventive action of thymol against carbon tetrachloride hepatotoxicity in mice [11]. Studies with rats have demonstrated the protective effects of thymol against titanium dioxide nanoparticles-induced hepatotoxicity and indomethacin-induced hepatic failure [12,13].
Extraction of astaxanthin from Haematococcus pluvialis with hydrophobic deep eutectic solvents based on oleic acid
2022, Food ChemistryCitation Excerpt :The antioxidant activity of TAO alone was 30-times higher than that of MAO (Fig. 6c, black bars), while oleic acid did not have any antioxidant activity at all. This finding can be attributed to the unique antioxidant properties of thymol, a well-known 1O2 quencher and anti-lipid peroxidation agent, suggested as a valid natural replacement for synthetic antioxidant food additives (Aeschbach et al., 1994; Alam et al., 1999; Kruk et al., 2000). Moreover, it is known that a whole carotenoid extract that contains astaxanthin is more antioxidant than astaxanthin alone, thanks to the synergism that occurs in the extract between astaxanthin and the polyunsaturated lipidic droplets strictly associated with astaxanthin itself; moreover, astaxanthin monoester has a stronger total antioxidant capacity than astaxanthin in the free form (Tan et al., 2021).
Cardioprotective effect of thymol against adrenaline-induced myocardial injury in rats
2020, HeliyonCitation Excerpt :Thymol is a naturally occurring phenolic compound and one of the primary active constituents present in the essential oil of Thymus vulgaris (Villanueva Bermejo et al., 2015). Reports have demonstrated that thymol has shown anti-oxidant, anti-microbial (Tsai et al., 2011; Wang et al., 2017), and hepatoprotective effects (Alam et al., 1999). Moreover, it has been demonstrated that thymol markedly inhibits the production of tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) in inflammation (Liang et al., 2014; Luna et al., 2017).
Andrographolide: A natural product template for the generation of structurally and biologically diverse diterpenes
2019, European Journal of Medicinal ChemistryEffects of thymol on amyloid-β-induced impairments in hippocampal synaptic plasticity in rats fed a high-fat diet
2018, Brain Research BulletinCitation Excerpt :Thy has demonstrated high ferric-reducing ability and a high reducing power that can be attributed to its higher phenolic contents (Aman et al.). Furthermore, the antioxidant, anti-inflammatory, and anti-lipid peroxidation effects of Thy are protective against toxicity that is related to cellular oxidative stress (Alam et al., 1999; Arab et al.; Kruk et al., 2000). Our experiment demonstrates that Thy possesses antioxidant properties that could improve hippocampal LTP induction in HFD + Aβ rats.
Hepatoprotective effect of thymol against subchronic toxicity of titanium dioxide nanoparticles: Biochemical and histological evidences
2018, Environmental Toxicology and Pharmacology
- ☆
Unspecified