Regular ArticleEvaluation of a Hybrid Artificial Liver Using a Polyurethane Foam Packed-Bed Culture System in Dogs☆
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A non-adhesive hybrid scaffold from gelatin and gum Arabic as packed bed matrix for hepatocyte perfusion culture
2015, Materials Science and Engineering CCitation Excerpt :The bioreactor should ideally provide necessary microenvironment for the hepatocytes to express differentiated functions with efficient mass transport between cells and medium [5]. Bioreactors used in BAL can be classified based on how it receives hepatocytes such as encapsulated suspension perfused bed [6,7], flat plate and monolayer [8] and hollow fiber systems [9]. Adherent hepatocytes easily lose their viability and fail to express liver specific functions due to deprivation of in vivo architecture, polarity and soluble cell signaling cues [4].
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M. J.T. Carrondo
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