Regular ArticleA New Family of Mouse Genes Homologous to the HumanMAGEGenes
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2020, Journal of Biological ChemistryCancer-testis antigens: Unique cancer stem cell biomarkers and targets for cancer therapy
2018, Seminars in Cancer BiologyCitation Excerpt :However, most CTAs are expressed in embryonic cells and extraembryonic structures (trophoblast and the ectoplacental cone) at a significantly lower levels than in the testes or cancer cells. Human and mouse pluripotent ESCs isolated from early embryos at the blastocyst stage were used as in vitro models of early development and lineage specification to analyze CTA expression patterns in pluripotent cells and their differentiated cell derivatives [44,104,133,134,138,139]. Undifferentiated human ESCs expressed several CTAs, such as MAGE-A3, -A6, -A4, -A8, POTE-2 and GAGEs [133,134,139,140].
Establishment of animal models to analyze the kinetics and distribution of human tumor antigen-specific CD8<sup>+</sup> T cells
2013, VaccineCitation Excerpt :While these studies have revealed that a number of different cancer vaccines, including short and overlapping peptides, protein, viral vectors and DNA, resulted in development of measurable immune responses, correlations between immunological and clinical responses were often week or difficult to observe [3]. MAGE-A4, another cancer/testis (CT) antigen, elicits MAGE-A4-specific CD4+ and CD8+ T cell responses in some patients with MAGE-A4-expressing cancers, indicating that MAGE-A4 is also an immunogenic protein [7–9]. We have recently reported a novel MAGE-A4 epitope presented by human leukocyte antigen (HLA)-A*2402 using a CD8+ T cell clone 2-28 [9].
THE USE OF XENOGENIC Testicular ANTIGENS FOR INDUCTION OF ANTITUMOR REACTIONS
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