Identification and Characterization of DPZF, a Novel Human BTB/POZ Zinc Finger Protein Sharing Homology to BCL-6

doi:10.1006/bbrc.2001.4689

Biochemical and Biophysical Research Communications

Volume 282, Issue 4, 13 April 2001, Pages 1067-1073

https://doi.org/10.1006/bbrc.2001.4689 Get rights and content

Abstract

The C2H2 zinc finger protein family is one of the largest families of transcription factors. We identified a novel BTB/POZ zinc finger gene from human dendritic cells (DC), which encodes a 733-residue protein with a BTB/POZ domain at the N-terminal and 4 C2H2 zinc fingers at C-terminal. It was designated dendritic cell-derived BTB/POZ zinc finger (DPZF). DPZF protein shares closest homology to BCL-6, with the highest homology present in the BTB/POZ and zinc finger domains. Like BCL-6, DPZF gene is localized on chromosome 3. It is widely expressed in hematopoietic tissues, including DC, monocytes, B cells, and T cells. DPZF protein expression is detectable in lymphoid neoplasm with a molecular mass of 100 kD, especially in B lymphoma. These indicate that DPZF may be a transcription factor closely related to BCL-6, and may be involved in hematopoiesis, oncogenesis, and immune responses.

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^☆: This work was supported by grants from the National Nature Science Foundation of China.

¹: These authors contributed equally to this work.

²: To whom correspondence should be addressed. Fax: (+86-21) 6538 2502. E-mail: [email protected].

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Regular ArticleIdentification and Characterization of DPZF, a Novel Human BTB/POZ Zinc Finger Protein Sharing Homology to BCL-6☆

Abstract

Curr. Opin. Cell Biol.

Cell

J. Biol. Chem.

Blood

Blood

Biochem. Biophys. Res. Commun.

Blood

Biochem. Biophys. Res. Commun.

Blood

Blood

Blood

EMBO J.

Proc. Natl. Acad. Sci. USA

Science

Science

Science

Proc. Natl. Acad. Sci. USA

Proc. Natl. Acad. Sci. USA

Genes Dev.

Regular Article
Identification and Characterization of DPZF, a Novel Human BTB/POZ Zinc Finger Protein Sharing Homology to BCL-6☆