Biochemical and Biophysical Research Communications
Regular ArticleCloning and Characterization of an α-Neurotoxin-Type Protein Specific for the Coral Snake Micrurus corallinus
References (30)
- et al.
Toxicon
(1971) - et al.
Toxicon
(1992) - et al.
Comp. Biochem. Physiol.
(1992) - et al.
Toxicon
(1994) - et al.
Toxicon
(1973) - et al.
Arch. Biochem. Biophys.
(1999) - et al.
J. Biol. Chem.
(1996) - et al.
J. Biol. Chem.
(1997) - et al.
Toxicon
(1989) - et al.
J. Immunol. Methods
(1984)
Clin. Res.
Rev. Ins. Med. Trop. São Paulo
Proc. Roy. Soc. Edin.
Eur. J. Biochem.
Cited by (29)
Antibodies against a single fraction of Micrurus dumerilii venom neutralize the lethal effect of whole venom
2023, Toxicology LettersCitation Excerpt :Some strategies to cope with this problem have been described, among them the identification and use of the most relevant toxins responsible for lethality as immunogens (de Castro et al., 2019; de la Rosa et al., 2019; Archundia et al., 2021; Cardona-Ruda et al., 2022). These toxins can be obtained as heterologous expression products by recombinant DNA technology (Silveira de Oliveira et al., 2000; Clement et al., 2016; de la Rosa et al., 2018; Guerrero-Garzón et al., 2018). Also, their corresponding recombinant antibodies could be obtained by modern biotechnology approaches to circumvent the current limitations of conventional antivenom production (Laustsen, 2018).
Integrative characterization of the venom of the coral snake Micrurus dumerilii (Elapidae) from Colombia: Proteome, toxicity, and cross-neutralization by antivenom
2016, Journal of ProteomicsCitation Excerpt :The predominant effect displayed by Micrurus venoms is neurotoxicity, commonly associated with the presence of 3FTx and PLA2 proteins. The former often act as α-neurotoxins, binding to the nicotinic acetylcholine receptor to postsynaptically block transmission at the neuromuscular junction [49,50]. A postsynaptic effect has been demonstrated for the crude venoms in some coral snake species such as M. lemniscatus [51], Micrurus pyrrhocryptus [52], M. mipartitus [53], and Micrurus dissoleucus [53].
Eastern coral snake Micrurus fulvius venom toxicity in mice is mainly determined by neurotoxic phospholipases A<inf>2</inf>
2014, Journal of ProteomicsCitation Excerpt :Partial sequence of fraction O had 100% identity with one of the transcripts, whereas fraction N had 64% with another one. RP-HPLC fractions that share some characteristics, including retention time and molecular weight of alpha-neurotoxins found in different Micrurus [6,13,46], were evaluated by electrophysiology as described in methods. Partial and reversible responses were observed with fractions C, D, FG, and H at 1 μM.
- 1
To whom correspondence should be addressed. E-mail: [email protected].