Biochemical and Biophysical Research Communications
Regular ArticleRegulation of Hepatic Stearoyl-CoA Desaturase Gene 1 by Vitamin A☆
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Cited by (53)
Lipid metabolism in colon cancer: Role of Liver X Receptor (LXR) and Stearoyl-CoA Desaturase 1 (SCD1)
2021, Molecular Aspects of MedicineRelevance of antioxidant vitamin supplementation for improvement of milk production, milk quality and energy status of lactating ewes
2019, Small Ruminant ResearchCitation Excerpt :In the present study, contrast analysis showed that vitamin A treatment significantly increased the Δ9-desaturase index of C16 and C18 FAs. Miller et al. (1997) found that administration of retinol palmitate to mice dramatically increased hepatic expression of Δ9-desaturase in both vitamin A-deficient and normal mice, indicating the important role of vitamin A in the activity of this enzyme. On the other hand, the Δ9-desaturase index assessed in the present study was not affected by vitamin C treatment, which suggests that the increase in USFA levels in the milk of ewes treated with vitamin C might have mediated by other mechanisms, mainly by suppression of microbial biohydrogenation.
Fatty acids, retinol and cholesterol composition in various fatty tissues of Celta pig breed: Effect of the use of chestnuts in the finishing diet
2015, Journal of Food Composition and AnalysisLipid metabolism in mammalian tissues and its control by retinoic acid
2012, Biochimica et Biophysica Acta - Molecular and Cell Biology of LipidsCitation Excerpt :Several genes encoding proteins in lipid metabolism appear to be regulated at the transcriptional level by RAR-dependent pathways, as indicated by functional promoter analysis and/or sensitivity of their expression levels to RAR-specific synthetic agonists (e.g. TTNPB). These include the gene for phosphoenolpyruvate carboxykinase, which is the rate-limiting enzyme of glyceroneogenesis and gluconeogenesis ([65] and references therein); the gene for stearoyl-CoA desaturase 1 [66,67], which converts saturated fatty acids into monounsaturated fatty acids and whose activity appears to influence fatty acid partitioning in liver by promoting fatty acid synthesis but decreasing oxidation [68]; the UCP1 gene [4,69–71]; the UCP3 gene [72]; and possibly the gene encoding medium-chain acyl-CoA dehydrogenase (MCAD), involved in mitochondrial β-oxidation [73]. For all of these genes up-regulation by retinoids in cellular and/or in vivo contexts has been reported.
Low levels of dietary vitamin A increase intramuscular fat content and polyunsaturated fatty acid proportion in liver from lean pigs
2011, Livestock ScienceCitation Excerpt :It has been found that the dietary vitamin A concentration alters the fatty acid composition of adipose tissue in sheep (Daniel et al., 2004), beef (Siebert et al., 2006) and pigs (Olivares et al., 2009a,b), while other experiments have not observed any effect of dietary vitamin A supplementation on the fatty acid composition of subcutaneous backfat from beef (Gorocica-Buenfil et al., 2007). Moreover, it has been proposed that dietary vitamin A might affect the stearoyl-CoA-desaturase (SCD) (Miller et al., 1997) and delta-5 desaturase (Zolfaghari et al., 2001) activities in rodents. Consequently, the effects of dietary vitamin A on IMF content and fatty acid composition need further research, not only because of the contradictory effects observed, but also because few studies have been carried out on pigs.
Hormonal and nutritional regulation of SCD1 gene expression
2011, BiochimieCitation Excerpt :PPAR-γ also targets SCD1 in adipose tissue [142–146] and a human study supports the role of PPAR-γ in SCD1 regulation [55]. Finally, in liver, Vitamin A, through its irreversibly oxidized form retinoic acid, was shown to activate SCD1 transcription by a classical mechanism involving a heterodimerization between the Retinoic Acid Receptor (RAR) and Retinoid X Receptor (RXR) [147]. However, in 3T3-L1 cells, retinoic acid appears to inhibit SCD1 expression by changing the relative composition of the AP-1 complex on the SCD1 promoter [148].
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Abbreviations used: FAS, fatty acid synthasePPAR, peroxisome proliferator-activated receptor; RAR, retinoic acid receptor; RXR, retinoid X receptor; SCD, stearoyl-CoA desaturase; T3R, thyroid hormone receptor;
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