Biochemical and Biophysical Research Communications
Regular ArticleBiosynthesis of Taxol: Enzymatic Acetylation of 10-Deacetylbaccatin-III to Baccatin-III in Crude Extracts from Roots ofTaxus baccata☆
References (0)
Cited by (36)
New molecular entities and structure–activity relationships of drugs designed by the natural product derivatization method from 2010 to 2018
2021, Studies in Natural Products ChemistryCitation Excerpt :Hydroxyl groups on the ribose ring can also be acetylated or replaced with other functional groups. Trifluridine, combined with tipiracil, is used in the treatment of metastatic colorectal cancer [25]. As nucleoside analogues prohibit DNA replication, some of the molecules are also used as anti-HIV drugs, such as zidovudine [26].
Enhanced catharanthine biosynthesis through regulation of cyclooxygenase in the cell suspension culture of Catharanthus roseus (L.) G. Don
2011, Process BiochemistryCitation Excerpt :Concentrations of serpentine and catharanthine, and cyclooxygenase activity were analyzed during the cultivation. The extraction method was modified based on the protocol as described [19,20]. The lyophilized cells (ca. 1 g) were pulverized in a mortar, and then extracted with 20 mL of 30 mmol/L HEPES buffer (pH 7.4) containing 3 mmol/L DTT and 0.8 g PVPP.
Microbial transformation of 7-epi-10-deacetylbaccatin III to 10-deacetylbaccatin III
2010, Journal of Molecular Catalysis B: EnzymaticEffect of methyl jasmonic acid on baccatin III biosynthesis
2006, Tsinghua Science and TechnologyExpression cloned cDNA for 10-deacetylbaccatin III-10-O-acetyltransferase in Escherichia coli: A comparative study of three fusion systems
2004, Protein Expression and PurificationMicrobial and reducing agents catalyze the rearrangement of taxanes
2001, Bioorganic and Medicinal Chemistry
- ☆
Abbreviations used: HPLC, high performance liquid chromatography; TLC, thin layer chromatography; 10-DAB, 10-deacetyl baccatin-III.
- 1
To whom correspondence should be addressed. Fax: (030) 31473522. E-mail: [email protected].