Biochemical and Biophysical Research Communications
Regular ArticleAn Allel-Specific Abnormal Transcript of the Heat Shock Protein 70 Gene in Patients with Major Depression
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The role of damage associated molecular pattern molecules (DAMPs) and permeability of the blood-brain barrier in depression and neuroinflammation
2022, Journal of NeuroimmunologyCitation Excerpt :HSP70 is closely related to depression. Shimizu et al. found an allele-specific aberrant transcript of the HSP70 gene on chromosome 6 in patients with major depression (Shimizu et al., 1996). Vlachos et al. (2014) evaluated whether HSP70 levels were associated with anxiety and depression in patients with ulcerative colitis (UC), reporting that HSP70 is induced by neutrophils and correlates with the degree of depression and anxiety reported by patients with UC.
Cellular stress mechanisms of prenatal maternal stress: Heat shock factors and oxidative stress
2019, Neuroscience LettersCitation Excerpt :An integrated transcriptome and methylome analysis of peripheral blood cells also implicated HSPA1L (HS70 protein-1 like) in youth with or at risk for bipolar disorder [59]. Major depressive disorder is associated with prenatal stress [156] and HSP70 abnormalities [173]. Pae and colleagues found that HSP70 single nucleotide polymorphisms are associated with worse symptomology and poorer response to antidepressant treatment [146], suggesting lower HSP70 expression and less induction of HSP70 upon treatment.
An altered peripheral IL6 response in major depressive disorder
2016, Neurobiology of DiseaseCitation Excerpt :A potential reason for therapeutic failure is that dysfunction in MDD is not restricted to the brain. MDD is a systemic illness with central and peripheral inflammatory changes at the core of MDD pathology (Erdem et al., 2011; Lisi et al., 2013; Noto et al., 2014; Powell et al., 2014; Setiawan et al., 2015; Shimizu et al., 1996; Slavich and Irwin, 2014). Patients with inflammatory diseases have a higher incidence of MDD than the general population (Dickens et al., 2002; Graff et al., 2009; Krishnadas et al., 2011; Lo Fermo et al., 2010), and 20–82% of patients treated with pro-inflammatory cytokines like interferon develop MDD (Capuron et al., 2002; Krishnadas et al., 2011; Musselman et al., 2001; Reichenberg et al., 2005).
Pattern of heat shock factor and heat shock protein expression inlymphocytes of bipolar patients: Increased HSP70-glucocorticoid receptor heterocomplex
2013, Journal of Psychiatric ResearchCitation Excerpt :A cytoprotective role of HSPs has been implicated in stress-tolerance and stress-related diseases (Macario & Conway de Macario, 2005). Patients with major depression have shown a 162-base deletion in the 5′-flanking region of HSP70-1 gene mRNA, although the data are conflicting (Shimizu et al., 1996, 1999; Takimoto et al., 2003). Interestingly, hsp70 and the hsp90 co-chaperone FKBP5 gene variants have been associated with the pathophysiology of BD (Pae et al., 2009; Willour et al., 2009; Binder, 2009; Zimmermann et al., 2011).
Glucocorticoid sensitivity of cognitive and inflammatory processes in depression and posttraumatic stress disorder
2010, Neuroscience and Biobehavioral ReviewsPhosphorylation status of glucocorticoid receptor, heat shock protein 70, cytochrome c and Bax in lymphocytes of euthymic, depressed and manic bipolar patients
2009, PsychoneuroendocrinologyCitation Excerpt :An important task of our study was to assess the implications of GR phosphorylation on various functions of lymphocytes, such as apoptosis. Bearing in mind that (a) pGR–S211 plays important role in apoptosis of lymphoid cells (Miller et al., 2005); (b) HSP70, an antiapoptotic, neuroprotective protein, has been implicated in pathogenesis of depression (Shimizu et al., 1996; Garrido et al., 2001; Takimoto et al., 2003; Yenari et al., 2005); (c) HSP70 acts at several levels of apoptosis like inhibition of translocation of Bax into mitochondria and release of cytochrome c from mitochondria (Arya et al., 2007); (d) blood leukocytes from depressed patients show signs of apoptosis (Eilat et al., 1999; Ivanova et al., 2007; Szuster-Ciesielska et al., 2008), we considered important to assess the total cellular HSP70 levels, cytosolic cytochrome c as well as Bax levels in BD patients. Our data indicate significantly decreased expression of the antiapoptotic HSP70 in all BD diagnostic groups, as compared to healthy subjects.