Symposium OverviewSymposium Overview: Toxicity of Non-Coplanar PCBs☆,☆☆,★
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Cited by (174)
PCBs in indoor air and human blood in Pittsfield, Massachusetts
2022, ChemosphereActions of toxicants and endocrine disrupting chemicals in birds
2022, Sturkie's Avian PhysiologyA computational insight into endocrine disruption by polychlorinated biphenyls via non-covalent interactions with human nuclear receptors
2021, Ecotoxicology and Environmental SafetyCitation Excerpt :Earlier studies on mechanism of PCB action indicate that some of the adverse health effects caused by PCBs in humans are mediated through binding to aryl hydrocarbon receptor (Rowlands and Gustafsson, 1997). Although most of these earlier studies focused on aryl hydrocarbon receptor-mediated toxicities, mounting data from recent literature suggest that nuclear receptors are also potential targets for PCB actions (Fischer et al., 1998; Bonefeld-Jørgensen et al., 2001; Portigal et al., 2002; Salama et al., 2003; Tavolari et al., 2006; Casati et al., 2013). Nuclear receptors are a class of proteins in metazoans that play a vital role in endocrine signaling and are therefore responsible for transcriptional regulation of numerous biological processes such as reproduction, development, homeostasis and metabolism (Robinson-Rechavi et al., 2003).
Emerging POPs-type cocktail signatures in Pusa caspica in quantitative structure-activity relationship of Caspian Sea
2021, Journal of Hazardous MaterialsCitation Excerpt :Given synergistic or antagonistic effects, dioxin-like compounds (DLCs) such as PCDDs, PCDFs, and non-DLCs such as non-coplanar PCBs and HCB have different molecular specific agonist (with high affinity for AhR or pregnane X/constitutive androstane (PXR/CAR) receptors) properties (Fig. 8) in a tissue-specific manner (Van den Berg et al., 2006; Sorg, 2014; Tavakoly Sany et al., 2016; Al-Salman and Plant, 2012), which is linked to mixtures toxicity effects in marine mammals (Nomiyama et al., 2014; Moon et al., 2009; Daelemans et al., 1993; Iwata et al., 2004). These mammalian chronic health hazards include immune suppression, hyperlipidemia, hepatotoxicity, neurotoxicity, metabolic dysfunction, carcinogenicity, and toxico-reproductive/developmental issues (Nomiyama et al., 2014; Dietz et al., 2019; Al-Salman and Plant, 2012; Zhang et al., 2012; Fischer et al., 1998). In complex mixtures, the mere tissue levels of these compounds with its respective TEF in Caspian seals can contribute to the total toxic equivalent (TEQWHO) concept and their toxicological significance (Van den Berg et al., 2006; Lee et al., 2014; Moon et al., 2009; Daelemans et al., 1993; Iwata et al., 2004; Chen et al., 2000).
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Symposium held at the 36th Annual Meeting of the Society of Toxicology, Cincinnati, OH.
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The research described in this article has been reviewed by the National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, and approved for publication. Approval does not signify that the contents necessarily reflect the views and policies of the Agency nor does mention of trade names or commercial products constitute endorsement or recommendation for use. Drs. Hugh Tilson and Jim McKinney are acknowledged for their critical review on an earlier version of the manuscript.
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Kimbrough, R. D.A. J. A.
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To whom correspondence should be addressed.