Mitochondrial Dysfunction in Cardiac Disease: Ischemia–Reperfusion, Aging, and Heart Failure

doi:10.1006/jmcc.2001.1378

Journal of Molecular and Cellular Cardiology

Volume 33, Issue 6, June 2001, Pages 1065-1089

https://doi.org/10.1006/jmcc.2001.1378 Get rights and content

Abstract

Mitochondria contribute to cardiac dysfunction and myocyte injury via a loss of metabolic capacity and by the production and release of toxic products. This article discusses aspects of mitochondrial structure and metabolism that are pertinent to the role of mitochondria in cardiac disease. Generalized mechanisms of mitochondrial-derived myocyte injury are also discussed, as are the strengths and weaknesses of experimental models used to study the contribution of mitochondria to cardiac injury. Finally, the involvement of mitochondria in the pathogenesis of specific cardiac disease states (ischemia, reperfusion, aging, ischemic preconditioning, and cardiomyopathy) is addressed.

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^☆: Please address all correspondence to: Edward J. Lesnefsky, M.DCardiology Section, Medical Service 111(W), Louis Stokes VA Medical Center, 10701 East Boulevard, Cleveland, OH 44106, USA.E-mail: [email protected]

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Review ArticlesMitochondrial Dysfunction in Cardiac Disease: Ischemia–Reperfusion, Aging, and Heart Failure☆

Abstract

Biochim Biophys Acta

J Biol Chem

J Biol Chem

Biochim Biophys Acta

FEBS Lett

Adv Enzyme Reg

J Biol Chem

Biochim Biophys Acta

Biochim Biophys Acta

J Biol Chem

J Biol Chem

Biochim Biophys Acta

J Theor Biol

Biochim Biophys Acta

Arch Biochem Biophys

Arch Biochem Biophys

J Biol Chem

Free Rad Biol Med

J Biol Chem

Free Rad Biol Med

Free Rad Biol Med

Mutat Res

Exp Gerontol

Mutat Res

Free Rad Biol Med

FEBS Lett

FEBS Lett

J Am Coll Cardiol

Biophys J

J Biol Chem

Biochim Biophys Acta

Biochim Biophys Acta

J Biol Chem

J Mol Cell Cardiol

Archiv Biochem Biophys

J Biol Chem

Arch Biochem Biophys

J Mol Cell Cardiol

J Biol Chem

Biochim Biophys Acta

Arch Biochem Biophys

J Mol Cell Cardiol

J Biol Chem

J Biol Chem

A morphological view on mitochondrial protein targeting

Microsc Res Tech

The importance of the outer mitochondrial compartment in regulation of energy metabolism

Mol Cell Biochem

Enrichment of carnitine palmitoyltransferase I and II in the contact sites of rat liver mitochondria

Biochem J

Cardiac metabolism—emergence, decline, and resurgence. Part II

Cardiovasc Res

Energy provision from glycogen, glucose, and fatty acids on adrenergic stimulation of isolated working rat hearts

Am J Physiol

Improved energy homeostasis of the heart in the metabolic state of exercise

Am J Physiol

Review Articles
Mitochondrial Dysfunction in Cardiac Disease: Ischemia–Reperfusion, Aging, and Heart Failure☆