Regular ArticleNonconvulsive Kainic Acid-Induced Seizures Elicit Age-Dependent Impairment of Memory for the Elevated Plus-Maze
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Retigabine calms seizure-induced behavior following status epilepticus
2014, Epilepsy and BehaviorCitation Excerpt :Although systemic KA treatment also resulted in higher entries into the center zone, the scores did not reach statistical significance since they also demonstrated increased immobility in the center (“freeze behavior”), suggesting that they may have had higher anxiety levels compared with KA + retigabine-treated animals. In the elevated plus maze, KA-treated and KA + retigabine-treated animals similarly explored the apparatus, spending more time in the open arms as well as traveling greater overall distance compared with the vehicle-treated animals, suggesting anxiety reduction occurred in both groups which is consistent with other KA seizure studies in rats [7,28,29]. However, the observation that KA + retigabine-treated rats did not significantly differ overall from systemically KA-treated rats in both open-field and elevated plus maze tasks supports the idea that retigabine may cause hyperlocomotion that may not be related to anxiety level.
Behavioral consequences of the mGlu5 receptor antagonist MTEP in immature rats
2011, Pharmacology Biochemistry and BehaviorCitation Excerpt :Data from various tests revealed a discrepancy among the studies; mGluR5 was found to impair or not affect learning and memory (Simonyi et al., 2005). The EPM paradigm can be also used to assess an adaptive form of spatial learning and memory (Itoh et al., 1990; Mikulecká et al., 2000). In our study, repeated exposure of the controls as well as the MTEP-treated animals led to a gradual decrease in the transfer latency; this trend was more distinct in 25-day-old animals than in 18-day-old animals.
Behavioral perseveration and impairment of long-term memory in rats after intrahippocampal injection of kainic acid in subconvulsive dose
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