Regular ArticleSurface receptors delivering opposite signals regulate the function of human NK cells☆
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The effect of alloferon on the enhancement of NK cell cytotoxicity against cancer via the up-regulation of perforin/granzyme B secretion
2013, ImmunobiologyCitation Excerpt :NK cell-mediated cytotoxicity and cytokine secretion are controlled by multiple receptor–ligand interactions (Lanier 1998b). In particular, precise balance between stimulatory and inhibitory signals received from surface receptors is very crucial in this process (Long and Rajagopalan 2000; Moretta et al. 2000; Tomasello et al. 2000). NK cells induce death of their targets by either tumor necrosis factor family and death receptor/death ligand interaction or granule exocytosis (Kägi et al. 1994).
Cell mediated innate responses of cattle and swine are diverse during foot-and-mouth disease virus (FMDV) infection: A unique landscape of innate immunity
2013, Immunology LettersCitation Excerpt :Besides the cytolytic activity against target cells, NK cells are important mediators of immune responses e.g., participating in immune responses controlled by dendritic cells [24]. These effector functions of NK cells are highly regulated by a balance between inhibiting and activating signals mediated through receptors harboring immunoreceptor tyrosine-based inhibitory motif (ITIM) or immunoreceptor tyrosine-based activation motif (ITAM), respectively, in their cytoplasmic tails [25]. During transportation of cattle, the stress response of these animals is characterized by activation of NK cells indicating that these play a role in innate response [26,27].
The correlation of autoantibodies and uNK cells in women with reproductive failure
2012, Journal of Reproductive ImmunologyCitation Excerpt :Ninety percent of NK cells in peripheral blood are CD56 + CD16 + (CD56dim) and these cells play an important role in the innate immune system (Eriksson et al., 2006) by producing immunoregulatory cytokines against several types of pathogens (Sentman et al., 2004). Their main function is cytolysis via specific cell surface molecules that detect target cells deficient in class 1 major histocompatibility complex (MHC) molecules (Moretta et al., 2000, 2003). Several studies have confirmed that women with recurrent miscarriage had an increased number of uNK cells in endometrial biopsies obtained in the peri-implantation period (Clifford et al., 1999; Kodama et al., 1998; Quenby et al., 1999).
Signalling events in natural killer cells
2010, Natural Killer CellsSignalling events in natural killer cells
2009, Natural Killer Cells: Basic Science and Clinical ApplicationStress, NK cells, and cancer: Still a promissory note
2007, Brain, Behavior, and ImmunityCitation Excerpt :Most of these obstacles remain relevant today and are hard to overcome in humans, but several are surmountable. First, recognition and response of NK cells to autologous malignant cells are based on a balance between numerous intracellular signals delivered by activating and inhibiting NK receptors that specifically interact with certain tumor determinants (Moretta et al., 2000). Thus, the perception of NK activity as being “non-specific” is misleading, and the use of non-autogenic target cells (e.g., K562 and YAC-1) can only partially simulate the relevant complex biological interactions.