Regular ArticleVitamin D3-Binding Protein as a Precursor for Macrophage Activating Factor in the Inflammation-Primed Macrophage Activation Cascade in Rats☆
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Potential role of GcMAF in suppressing the severity of COVID-19-induced immune responses: Lesson learned from HIV
2020, Medical HypothesesCitation Excerpt :It carries a trisaccharide consisting of N-acetylgalactosamine with dibranched galactose and sialic acid termini at 420 threonine residue [17]. Stepwise hydrolysis of Gc protein by the inducible membranous β-galactosidase of stimulated B-lymphocytes, and by the Neu-1 sialidase of T-lymphocytes converts it into the active GcMAF [17–19]. On the contrary, deglycosilation of Gc protein by action of the enzyme alpha-N-acetylgalactosaminidase, named nagalase, secreted from HIV-infected cells leads to lack of macrophage activation and to immunosuppression, as a consequence [14,15].
Glutathione peroxidase-1 inhibits transcription of regenerating islet-derived protein-2 in pancreatic islets
2019, Free Radical Biology and MedicineCitation Excerpt :This protein is abundantly expressed in pancreatic β cells and acts as an element of the “cell-clock” that contributes to β cell dysfunction and development of diabetes through alterations of the cellular circadian rhythms [62]. Although DBP was believed to participate in redox-regulated inflammatory signaling [63], little is known about its regulation by the redox changes. Notably, the present study reveals a novel function and mechanism for DBP in the GPX1-mediated inhibition of Reg2 transcription.
Vitamin D binding protein. A multifunctional protein of clinical importance
2014, Advances in Clinical ChemistryCitation Excerpt :In cancer patients, an increased hepatic production of the extracellular matrix-degrading enzyme, alpha-N-acetylgalactosaminidase, has been observed, resulting in a loss of DBP precursor activity and a severe immunosuppression [85,94]. The inverse correlation between N-acetylgalactosaminidase activity and DBP concentration provides support for the idea that deglycosylation of DBP is the major mechanism of immunosuppression in cancer patients [85]. Over the last decades, multiple tumor markers have been developed that are used in the screening, diagnosis, and treatment of various cancers.
Vitamin D, the placenta and pregnancy
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2010, Biochimica et Biophysica Acta - Proteins and Proteomics
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This investigation was supported in part by U.S. PHS Grant AI-32140 to N.Y.
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To whom correspondence and reprint requests should be addressed at Laboratory of Cancer Immunology and Molecular Biology, Albert Einstein Cancer Center, Korman Research Pavilion, 5501 Old York Roads, Philadelphia, PA 19141.