Biochemical and Biophysical Research Communications
Regular ArticleBovine Milk Kininogen Fragment 1·2 Promotes the Proliferation of Osteoblastic MC3T3-E1 Cells☆
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Cited by (34)
Milk basic protein supplementation exerts an anti-inflammatory effect in a food-allergic enteropathy model mouse
2018, Journal of Dairy ScienceCitation Excerpt :Milk basic protein is composed of some proteins; the principal protein components of MBP are lactoferrin (LF), lactoperoxidase (LPO), angiogenin (ANG), and cystatin C (CysC) as previously reported (Matsuoka et al., 2002; Aoe et al., 2005; Kruger et al., 2007; Morita et al., 2008, 2011, 2012; Ishida et al., 2017). In addition, other milk proteins such as high mobility group (HMG)-like protein and kininogen fragment 1/2 are slightly included (Yamamura et al., 1999, 2000, 2006). It has also reported that the content of casein in MBP was only a trace amount [GRAS Notice 000196 (2006); Goodman et al., 2007].
The bone-strengthening activity of milk basic protein is not dependent on lactoferrin
2012, International Dairy JournalCitation Excerpt :Notably, IGF-1 and TGF-β were reported to accelerate collagen synthesis by osteoblasts (Canalis & Lian, 1988). We previously purified and identified several active components of MBP, including high mobility group (HMG)-like proteins (Yamamura, Takada, Goto, Kumegawa, & Aoe, 1999), fragment 1/2 of high molecular weight kininogen (Yamamura, Morita, Takada, & Kawakami, 2006; Yamamura, Takada, Goto, Kumegawa, & Aoe, 2000), cystatin C (Matsuoka et al., 2002), angiogenin (Morita, Matsuyama, Serizawa, Takeya, & Kawakami, 2008), and lactoperoxidase (Morita et al., 2011). Fragment 1/2 of high molecular weight kininogen and HMG-like proteins were found to stimulate the growth activity of MC3T3-E1 cells.
Functional foods and bone health
2011, Functional Foods: Concept to Product: Second EditionKinins and Neuro-osteogenic Factors
2008, Principles of Bone Biology: Volume 1-2, Third EditionFractionation of bovine whey proteins and characterisation by proteomic techniques
2008, International Dairy JournalSafety evaluation of a milk basic protein fraction
2007, Food and Chemical Toxicology
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Abbreviations used: HMW, high molecular weight; α-MEM, alpha-modified Eagle's medium; FBS, fetal bovine serum
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