Symposium Review ArticlesGastrointestinal Parameters That Influence Oral Medications
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Clinical translation of oral peptide delivery technologies
2022, Oral Delivery of Therapeutic Peptides and ProteinsMicellar buccal film for safe and effective control of seizures: Preparation, in vitro characterization, ex vivo permeation studies and in vivo assessment
2021, European Journal of Pharmaceutical SciencesCitation Excerpt :Considering the different routes of administration, the oral route remains the safest, convenient, and economical one, suitable for different types of drug candidates, in addition to the ease of transportation and storage (Ronchi et al., 2019). Unlikely, oral administration confronts some physiological obstacles owing to several factors, comprising the surface area of the GIT system, gastrointestinal transit time, commensal flora, pH, and enzymatic activity (Dressman et al., 1993). The buccal administration route can readily replace the oral delivery avoiding the aforementioned constraints.
Development and evaluation of budesonide-based modified-release liquid oral dosage forms
2019, Journal of Drug Delivery Science and TechnologyCitation Excerpt :This is done to protect the loaded drugs from biological fluids or potential issues imposed by the physiologic variabilities of gastrointestinal tract (GIT) (e.g. pH, the commensal flora, enzymatic activity, surface area and gastrointestinal transit time). It also prevents delivery of the drug outside the so-called absorption window, ensuring its release in the target site as extensively as possible [8]. An example of this latter case is colon delivery, for which it is necessary to prevent the release of active ingredients in the entire gastric residence and the small intestinal transit.
Development and evaluation of an omeprazole-based delayed-release liquid oral dosage form
2019, International Journal of PharmaceuticsCitation Excerpt :Above all, the oral route improves patient compliance (Pinto, 2010). However, oral administration faces some physiological constraints due to the heterogeneity of the gastrointestinal system (e.g. pH, the commensal flora, gastrointestinal transit time, enzymatic activity and surface area) (Dressman et al., 1993). Conventional dosage forms do not allow all the potential issues imposed by the physiology of gastrointestinal tract to be overcome or to provide controlled release of the drug.
A Delivery System for Oral Administration of Proteins/Peptides Through Bile Acid Transport Channels
2019, Journal of Pharmaceutical SciencesOral peptide delivery: Translational challenges due to physiological effects
2018, Journal of Controlled ReleaseCitation Excerpt :In addition to inter subject variations, diseases can also alter the gastric emptying time. Achlorhydria has been shown to go together with delayed gastric emptying [50]. In a study comprising of elderly achlorhydria patients, it was observed that, on an average, the patients took 40 min to empty 50% of a 300 mL of consumed orange juice.