ArticlesMarked Heterogeneity in the Intrahepatic Distribution of Quinidine in Rats: Implications in Pharmacokinetics
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Heterogeneity of the intrahepatic portal venous blood flow: Impact on hepatocyte transplantation
2013, Microvascular ResearchCitation Excerpt :Further evidence for regional variations in portal venous blood supply within the liver is given by intrahepatic distribution analyses of several pharmaceutical compounds. For instance, after intravenous steady state infusion and using different sampling sites of the liver, quinidine concentrations were found to vary markedly within each lobe (up to 52-fold) and between lobes (up to 25-fold) of the same liver (Lee and Chiou, 1990). As similar uneven distributions were reported for other chemicals (Faa et al., 1987; Flores et al., 1988; Thompson et al., 1959), the general assumption of the liver behaving as a well-stirred compartment was strongly challenged and, among others, unexpected variations of the portal venous blood flow were determined as an obvious reason.
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