Research Articles
Novel Method for Bioavailability Assessment

https://doi.org/10.1002/jps.2600620923Get rights and content

Abstract

An alternative strategy is proposed for the assessment of bioavailability. It is based on estimates of renal clearance, plasma clearance, and urinary excretion of unchanged drug. The method is totally compatible with pharmacokinetic methods but lends itself to a more flexible sampling schedule and is model independent.

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