Can the genes communicate with each other after birth? An international cross‐sectional study

Abstract Background Various factors contribute to the pathogenesis of a disease. These include genetic factors, family history, and some idiopathic causes. Genetic makeup has an important role in the progression of disease. This is due to mutations in genetic material, that is, deoxyribonucleic acid (DNA). Methodology This is a cross‐sectional study that involved 5000 participants distributed across 250 countries. All the participants were randomly selected and asked to fill out the online survey. All the participants were fully informed about the study's purpose before providing their consent. Results The participants were distributed among 250 countries. Their age mean (standard deviation) is 46.7 (12.4). We discovered a significant difference between those who have genetic or congenital diseases and those who have a family history of the disease. Also, there is a statistically significant difference between the recurrence of the disease and the duration of the visits of close relatives who have the same disease. Conclusion The study suggests that there might be some ways, through gene waves or the environment, in which a gene changes the expression of other genes of similar sequence in different individuals when the required period of contact is provided. In the future, this theory might explain the idiopathic nature of some diseases.

genetic factors. These factors cause variation in each individual's immune system, which in turn determines the individual's immunity against pathogens. 1,2 The majority of cancers are caused by genetic mutations and changes. These mutations are affected by genetic and environmental factors. Among various possible factors causing disease in humans, family history is one of the most important factors leading to common disease complexes like cancer, heart disease, psychiatric illnesses, diabetes, and autoimmune disorders. 2 A person's risk of developing a disease can be predicted by family history. Genetic variation inherited by the individual can lead to the pathogenesis of disease. 2 A complete understanding of the genome and genetics is vital for evaluating the progression of disease and devising a therapeutic strategy for prevention. interaction between environmental initiating factors and genetic factors is also involved in disease progression. 3 Some diseases have a seasonal onset, like allergies caused by environmental factors. Exposure to ultraviolet light can cause skin disorders in susceptible individuals. 3 Risk for environmental diseases is increased by interactions among genetic factors, acquired susceptibility, and environmental factors.

| Study design
We have undertaken a cross-sectional, international, multicenter study, using an online self-administered questionnaire, on the cohort composed of participants who were randomly chosen from 250 countries.

| Setting
The survey was conducted in each country had a center, and there was an administrator for each country to select the cases.

| Participants
An online survey was conducted randomly among the general population and included only those who completed the survey properly. There was a consent form for participants at the beginning of each survey and an explanation of the study. Ethical approval was obtained from the ethical committee of the University of Baghdad, College of Medicine.

| Variables
The questionnaire consisted of 30 questions divided into two sections. The answers were divided into single answers and multiple-choice answers for both quantitative questions and qualitative questions.

| Study size
The study involved 5000 participants distributed in 250 countries.

| Statistical method
We used SPSS version 24 in finding a relationship between our variables for significance and correlation. In the analysis, the χ 2 and Fisher's tests were used.

| RESULTS
The participants were 5000 distributed among 250 countries. Their age mean (standard deviation) is 46.7 (12.4). Table 1 demonstrates the demographic data related to the participants.
The questionnaire involved 16 questions about the role of genes in the disease's transmission and the cofounders; Table 2 demonstrated the percentages of the responses for each question.
In Figure 1, we can see the relationships between the duration of staying close to the parents or close relatives and the duration of the diseases and their recurrence.
We found a significant difference between those who have genetic diseases or congenital diseases and the incidence of the disease in their families (Table 3). Also, there is a statistically significant difference between the recurrence of the disease and the duration of the visits of close relatives who have the same disease.

| DISCUSSION
Our study seeks to discover the relationship between the period of stay with the family having or not having genetic disease and the recurrence of disease after appropriate management in an international population sample to determine whether genes communicate with each other after birth between individuals. This study only emphasizes the degree of association between the length of stay with families and disease recurrence and has nothing to do with a causal relationship. We recruited a large sample of individuals of varying ages with a history of genetic disease in them or family members living away from the family and found that whether visiting and staying close to your family members has an impact on disease behavior and how long disease recurs in subjects. There is a  We think that there may be some types of communication signalswe called them "gene waves"-through which genes communicate with each other. We have considered the distance of separation, the period of contact, and the duration after which recurrence occurs.
The study suggests that there might be some ways, through gene waves or the environment, in which a gene changes the expression of other genes of similar sequence in different individuals when the required period of contact is provided. In the future, this theory might explain the idiopathic nature of some diseases. Of course, our study has some limitations as well. We tried our best to control the confounding by matching the variables as far as we could, but there may be some variables that might have influenced the results that should be discovered by further research. As our study is novel in nature, there is very little literature available on this, and a lot of debate is required to find out whether there is real communication or not. As our study is cross-sectional in nature, we have only found the associations between the variables, not the casual relationships between them.

| CONCLUSION
We simply wanted to find a relationship between genes with similar sequences and each other in different individuals by considering family history of inherited diseases in this study. We have listed some evidence that supports our hypothesis. We think that there may be some types of communication signals-we called them "gene waves"-through which genes communicate with each other. We have considered the distance of separation, the period of contact, and the duration after which recurrence occurs. The study suggests that there might be some ways, through gene waves or the environment, in which a gene changes the expression of other genes of similar sequence in different individuals when the required period of contact is provided. In the future, this theory might explain the idiopathic nature of some diseases.