Conformation and Aromaticity Switching in a Curved Non‐Alternant sp2 Carbon Scaffold

Abstract A curved sp2 carbon scaffold containing fused pentagon and heptagon units (1) was synthesized by Pd‐catalyzed [5+2] annulation from a 3,9‐diboraperylene precursor and shows two reversible oxidation processes at low redox potential, accompanied by a butterfly‐like motion. Stepwise oxidation produced radical cation 1 .+ and dication 1 2+. In the crystal structure, 1 exhibits a chiral cisoid conformation and partial π‐overlap between the enantiomers. For the radical cation 1 .+, a less curved cisoid conformation is observed with a π‐dimer‐type arrangement. 1 2+ adopts a more planar structure with transoid conformation and slip‐stacked π‐overlap with closest neighbors. We also observed an intermolecular mixed‐valence complex of 1⋅(1 .+)3 that has a huge trigonal unit cell [(1)72(SbF6)54⋅(hexane)101] and hexagonal columnar stacks. In addition to the conformational change, the aromaticity of 1 changes from localized to delocalized, as demonstrated by AICD and NICS(1)zz calculations.

Curved polycyclic aromatic hydrocarbons (PAHs) have attracted considerable interest over the last decade in the context of research on carbon-based materials. [1] In contrast to their flat counterparts, [2] curved p-conjugated PAHs exhibit better solubility, a wealth of structural topologies including chirality, [3] and may enable pronounced dynamic structural changes upon photoexcitation or electrochemical reduction/ oxidation. [4] With this motivation, incorporation of nonhexagonal rings into polybenzenoid p-networks has evolved as an important strategy toward curved PAHs with different curvatures. An embedded four-or five-membered ring in a hexagonal p-network induces a positive curvature, while inclusion of a heptagon or octagon produces a negative curvature. [3a] PAHs that contain individual pentagon and heptagon in a hexagonal network of sp 2 carbons may have both positive and negative curvatures, [5] while those that incorporate fused pentagon and heptagon afford planar or contorted p-scaffolds as demonstrated in recently reported azulene-embedded polyaromatics. [6] Compared to widely studied positively curved PAHs, [7] saddle-shaped ones with negative curvature were less developed until recently due to synthetic challenges. [8,9] Cycloheptatrienyl (C 7 H 7 ) is a non-aromatic seven-membered ring with a nonplanar structure. Upon loss of an electron, it produces a non-benzenoid tropylium cation (C 7 H 7 + ). This intriguing p-system has a planar geometry with 6 p-electrons fully delocalized over the whole ring, which satisfies Hückels [4n+2] rule for aromaticity. We reason that the negatively curved PAHs bearing heptagons comply with the identical rule upon oxidations, which would cause reorganization of their geometries and pronounced redistribution of the p-electrons. These features may play decisive roles not only for their reactivity [10] but also performance in battery applications [11] or as organic semiconductors. [12] Conformational switching can also lead to distinct stacking modes in the solid-state that strongly affect the electronic properties of materials. [13] However, to the best of our knowledge, a fundamental study concerning the structural and electronic properties of negatively curved p-structures at different oxidation states remains unexplored.
Herein, we report a new negatively curved non-alternant sp 2 carbon scaffold, and its structural changes upon oxidation to the radical cation and dication species by stepwise oxidation. The electronic properties, magnetic aromaticity, conformational variations, and stacking arrangements in the solid-state of this saddle-shaped PAH at different oxidation states are investigated both experimentally and theoretically.
In our previous work, [14] we developed a synthetic strategy for heptagon-containing PAHs that formally include two pleiadiene moieties. [15] In order to achieve a more electronrich curved PAH for studying oxidation states, PAH 1 that contains fused pentagon and heptagon was thus synthesized by the above-mentioned method. [14] Thus, a two-fold palladium-catalyzed [5+2] annulation of 3,9-diboraperylene [16] and 1,2-dibromoacenaphthylene afforded azulene-embedded PAH 1 in an isolated yield of 15 % (Scheme 1). PAH 1 exhibits high solubility in common organic solvents and good stability in the solid-state with no significant decomposition after several weeks under ambient conditions. We first investigated the redox properties of curved PAH 1 by cyclic voltammetry and square wave voltammetry ( Figure 1). The cyclic voltammogram of 1 shows two lowlying reversible oxidation processes at 0.00 V and 0.20 V (vs. Fc +/0 ). This eagerness toward oxidation arises from the two embedded heptagons ( Figure S8, Table S12). Moreover, a quasi-reversible reduction process at À1.78 V and an irreversible one at À1.92 V were observed. Motivated by the well-defined reversibility of the oxidation processes of 1, we next turned our attention to the stepwise chemical oxidation of 1 with NO·SbF 6 (Scheme 1). Single-electron chemical oxidation with one equivalent of NO·SbF 6 afforded radical cation 1C + . Addition of another equivalent of NO·SbF 6 to the solution of 1C + produced dication 1 2+ that can also be obtained directly by two-electron oxidation of 1. Its noteworthy that both of the two cationic species can convert back to the neutral species 1 upon reduction with triethylamine. The structures of charged species 1C + and 1 2+ as well as neutral species 1 could be unequivocally confirmed by NMR spectroscopy (for 1 and 1 2+ ) and single crystal X-ray crystallography. Likewise, the optical properties of all isolated species of 1 could be examined by UV/Vis absorption spectroscopy ( Figure S5).
Crystallographic analyses of 1, 1C + , and 1 2+ revealed their molecular conformations and intermolecular interactions in the solid-state ( Figure 2). [17] The crystal structure of the neutral species 1 shows a twisted saddle-shaped cisoid conformation (Figure 2 b), that results from the distorted geometry of the seven-membered ring and steric hindrance between the anthracene and naphthalene moieties. The dihedral angle between the mean planes of two acenaphtha-lene moieties is 86.38. Similarly, radical cation 1C + exhibits a cisoid conformation with a larger dihedral angle of 110.58 or 90.38 (Figure 2 e). The counter anion (SbF 6 À ) stays beside the central anthracene core and has no close contact with the seven-membered rings (Figure 2 d, e). In contrast, dication 1 2+ adopts a transoid conformation in the crystal (Figure 2 h) with a dihedral angle of 151.68 between the mean planes of the acenaphthalene and anthracene units. Two counter anions (SbF 6 À ) reside closely to the heptagons and are slightly shifted towards the central benzene ring, suggesting the presence of tropylium-like cations. This observation is also in line with the DFT calculated charge distribution and electrostatic potential maps where the positive charges are mainly located on the heptagons ( Figure S8, Table S12). The cis-and trans-conformations of 1, 1C + and 1 2+ were also studied by DFT calculations at B3LYP/6-31 + G(d) level of theory. The C 2symmetric cisoids of 1, 1C + and 1 2+ are lower in energy than the corresponding C i -symmetric transoids by 12.1, 7.2, and 10.3 kJ mol À1 , respectively. This suggests that the cis-conformations are more energetically favorable in vacuum, and the trans-conformation of 1 2+ in the crystal state might arise from the effects of the two counterions at the opposite sides of pscaffold and the crystal packing forces. [18] Interestingly, upon partial oxidation of 1 with NO·SbF 6 , we obtained crystals of a mixed-valence (MV) species 1·(1C + ) 3 that consists of 1/4 equivalent of neutral species 1 and 3/ 4 equivalents of radical cation 1C + (Figure 2 j-m). This MV complex 1·(1C + ) 3 has similar dihedral angles as the radical cation 1C + (Figure 2 k). The crystal structure of 1·(1C + ) 3 features a huge trigonal unit cell (91 777 (9) 3 ) that contains 72 molecules with cisoid conformation, 54 SbF 6 À counter anions and 101 disordered hexane molecules, [(1) 72 (SbF 6 ) 54 ·-(hexane) 101 ]. Remarkably, we could also identify the MV species in solution by UV/Vis/NIR absorption spectroscopy which suggests the formation of supramolecular adducts of this composition already in solution ( Figure S4).
The packing arrangements of the series of crystals 1, 1·(1C + ) 3 , 1C + , 1 2+ reflect their oxidation state (Figure 2 c, f, i, m). In the crystal packing, the neutral species 1 has conformational chirality and exists as a pair of enantiomers (Figure 2 c, highlighted in green and blue). These two enantiomers have partial slip-stacked p-p overlap between two acenaphthylene moieties with a distance of 3.47 . Similarly, dication 1 2+ shows such "head-to-tail" p-p interaction through two acenaphthylene units separated by 3.63 (Figure 2 i). Unlike 1 and 1 2+ , radical cation 1C + shows a cofacial p-dimer arrangement that might support the stability of the radical species (Figure 2 e, f). [19] The centroid-centroid distance between two central benzene rings was measured as 3.67 . These p-dimers pack into staggered arrangements through partial p-p interactions of adjacent acenaphthylene units with an interplanar distance of 3.59 . The most intriguing structure formed by the mixed-valence species 1·(1C + ) 3 reveals a self-assembly into an infinite columnar arrangement through "concave-convex" and "convex-convex" p-p-stacking modes with an average distance of 3.77 for two contiguous p-systems in each column. [7c, 20] Furthermore, these columns self-organize into hexagonal arrays, in which the void space of the hollow hexagons is occupied by  Half-wave potentials were calculated from CV and SWV with ferrocene/ ferrocenium (Fc/Fc + ) as an internal reference.
To explore the aromaticity and electronic structures of 1 at different oxidation states, we performed anisotropy of the induced current-density (AICD) [21] and nucleus-independent chemical shift (NICS) calculations [22] at (U)B3LYP/6-31 + G(d) level of theory (Figure 3). The AICD plot of neutral species 1 shows diamagnetic ring currents on the two terminal naphthalene and central anthracene moieties with large negative NICS(1) zz values, suggesting a localized aromaticity of the respective moiety. The heptagons of neutral 1 have counter-clockwise paramagnetic ring currents and a large positive NICS(1) zz value of 17.67, indicating their strong antiaromaticity. [6c] The antiaromaticity of heptagons is evident, since the shielded protons on the seven-membered rings resonate at 7.17 ppm in 1 H NMR spectrum ( Figure S1). Moreover, the small positive NICS(1) zz value (6.89) for pentagons suggests weak antiaromaticity, different from that Figure 2. a-i) X-ray crystal structures of neutral species 1 (a-c), radical cation 1C + (d-f), dication 1 2+ (g-i), shown as the front view (left), side view (middle), and crystal packing (right). j-m) X-ray crystal structures of mixed valence species 1·(1C + ) 3 , showing the selected repeating unit (j); side view (k); columnar p-stacks (l); and crystal unit cell from top view (m). Thermal ellipsoids shown at 50 % probability; solvent molecules and hydrogen atoms are omitted for clarity. C dark grey, F yellow, Sb magenta.
in pristine acenaphthylene in which the pentagon has a nonaromatic character. [23] In contrast to 1, the dication 1 2+ exhibits a clockwise diamagnetic ring current alongside the periphery of the half p-conjugated framework (Figure 2 c). In accordance to this, the central benzene ring becomes antiaromatic with a positive NICS(1) zz value of 11.25. The heptagons and pentagons of 1 2+ have weak aromaticity with NICS(1) zz values of À4.0 and À4.5, respectively. This result can be further supported by the 1 H NMR spectrum (Figure S1), in which the chemical shift of the proton on heptagonal rings is deshielded from 7.17 ppm in 1 to 9.04 ppm in 1 2+ . [24] Radical cation 1C + shows fragmental delocalized aromaticity with clockwise ring currents over naphthalene and the marginal benzene rings of the anthracene moiety. This is because of a very weak (anti)aromaticity of the pentagon, heptagon and central benzene rings of 1C + . These variations of aromaticity indicate that this curved pscaffold undergoes delocalization of p-electrons along with conformational changes upon stepwise oxidation.
The calculated changes in aromaticity are supported by the bond length analyses of the molecular structures of 1 in the crystals at different oxidation states ( Figure S7, Tables S6,7). Thus, the length of bond a changes from 1.353(3) for 1 to 1.388 (9) for 1 2+ . This corresponds to a shift from a conjugated double bond (-C = C-, 1.345 ) to an aromatic bond (-C Ar ' C Ar -, 1.384 ). [25] Concomitantly, the bond length of b becomes longer from 1.432(3) for 1 to 1.478 (9) for 1 2+ . This can be interpreted as a shift from an equivalent bond of anthracene (-C9 ' C9a-, 1.400 ) to a single bond between two aromatic carbons (-C Ar -C Ar -, 1.487 ). [25] All these bond length changes as well as other characteristic bond lengths of the seven-membered and central benzene rings in 1 have systematic variations as the oxidation state increases. Its worth mentioning that we observed two crystallographic isomers of the MV species 1·(1C + ) 3 that derived from the intra-crystal charge delocalization of neutral and radical cation species. On the basis of bond length analysis (Table S6), one ( Figure 2, highlighted in blue, MV I ) is closer to neutral species and the other (highlighted in green, MV II ) is closer to radical cation (Figure 2 k). [26] In summary, we introduced a negatively curved nonalternant PAH containing two fused pentagon and heptagon units and elucidated its structural and functional changes upon stepwise chemical oxidation. X-ray crystallographic analyses revealed how this saddle-shaped PAH changes its conformation and aromatic ring currents as the oxidation state increases. Thus, along with the butterfly-like conformational motions from cisoid to transoid, the magnetic aromaticity alters from localization to delocalization according to AICD plots and NICS(1) zz calculations. Our study on this curved non-alternant PAH serves to interrelate the effects of charges on the structural and electronic properties as well as packing preferences of nanographenes containing odd-membered ring defects.