XANTHOQUINODINS, NEW ANTICOCCIDIAL AGENTS PRODUCED BY Humicola sp. PRODUCTION, ISOLATION AND PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES

NORIKO TABATA; YASUKO SUZUMURA; HIROSHI TOMODA; ROKURO MASUMA; KATSUJI HANEDA; MASANORI KISNI; YUZURU IWAI; SATOSHI OMURA

doi:10.7164/antibiotics.46.749

XANTHOQUINODINS, NEW ANTICOCCIDIAL AGENTS PRODUCED BY Humicola sp.

PRODUCTION, ISOLATION AND PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES

NORIKO TABATA, YASUKO SUZUMURA, HIROSHI TOMODA, ROKURO MASUMA, KATSUJI HANEDA, MASANORI KISNI, YUZURU IWAI, SATOSHI OMURA

Author information

JOURNAL FREE ACCESS

1993 Volume 46 Issue 5 Pages 749-755

DOI https://doi.org/10.7164/antibiotics.46.749

Details

Abstract

Humicola sp. FO-888, a soil isolate, was found to produce a series of new anticoccidial compounds. Five active compounds, designated xanthoquinodins Al, A2, A3, Bl and B2 were isolated from the fermentation broth of the producing strain by solvent extraction and HPLC. Xanthoquinodins inhibited the growth of Eimeria tenella in an in vitro assay system using BHK-21 cells as a host. No schizont in the cells was observed at concentrations of 0.02-0.2μg/ml for xanthoquinodins Al, A3, Bl and B2 and at 0.02μg/ml for xanthoquinodin A2.

Corresponding author

Register with J-STAGE for free!