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Bioactive secondary metabolites produced by microorganisms associated with plants

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Abstract

In the past few decades groups of scientists have focused their study on relatively new microorganisms called endophytes. By definition these microorganisms, mostly fungi and bacteria, colonise the intercellular spaces of the plant tissues. The mutual relationship between endophytic microorganisms and their host plants, taxanomy and ecology of endophytes are being studied. Some of these microorganisms produce bioactive secondary metabolites that may be involved in a host-endophyte relationship. Recently, many endophytic bioactive metabolites, known as well as new substances, possesing a wide variety of biological activities as antibiotic, antitumor, antiinflammatory, antioxidant, etc. have been identified. The microorganisms such as endophytes may be very interesting for biotechnological production of bioactive substances as medicinally important agents. Therefore the aim of this review is to briefly characterize endophytes and summarize the structuraly different bioactive secondary metabolites produced by endophytic microorganisms as well as microbial sources of these metabolites and their host plants.

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References

  • Araújo W.L., Maccheroni W.Jr., Aguilar-Vildoso C.I., Barroso P.A., Saridakis H.O. & Azevedo J.L. 2001. Can. J. Microbiol. 47: 229–236.

    Article  PubMed  Google Scholar 

  • Barz W., Daniel S., Hinderer W., Jaques U., Kessmann H., Koster J. & Tiemann K. 1988. In: Pais M., Mavituna F. & Novais J. (eds), Plant Cell Biotechnology, Springer (NATO ASI series), Berlin, Heidelberg, New York, pp. 211–213.

    Google Scholar 

  • Brady S.F., Wagenaar M.M., Singh M.P., Janso J.E. & Clardy J. 2000. Org. Lett. 14: 4043–4046.

    Article  CAS  Google Scholar 

  • Castillo U.F., Strobel G.A., Ford E.J., Hess W.M., Porter H., Jensen J.B., Albert H., Robison R., Condron M.A.M., Teplow D.B., Stevens D. & Yaver, D. 2002. Microbiol. 148: 2675–2685.

    CAS  Google Scholar 

  • Castillo U., Harper J.K., Strobel G.A., Sears J., Alesi K., Ford E., Lin J., Hunter M., Maranta M., Ge H., Yaver D., Jensen J.B., Porter H., Robison R., Millar D., Hess W. M., Condron M. & Teplow D. 2003. FEMS Microbiol. Lett. 224: 183–190.

    Article  PubMed  CAS  Google Scholar 

  • Coombs J.T., Michelsen P.P. & Franco C.M.M. 2004. Biol. Control 29: 359–366.

    Article  Google Scholar 

  • Dos Santos R. & Rodrigues-Fo E. 2003. Z. Naturforsch. 58c: 663–669.

    Google Scholar 

  • Ezra D., Castillo U.F., Strobel G.A., Hess W.M., Porter H., Jensen J.B., Condron M.A., Teplow D.B., Sears J., Maranta M., Hunter M., Weber B. & Yaver D. 2004. Microbiol. 150: 785–793.

    Article  CAS  Google Scholar 

  • Fábio A., Proença B. & Edson R.F. 2005. Biochem. Syst. Ecol. 33: 257–268.

    Article  CAS  Google Scholar 

  • Germaine K., Keogh E., Garcia-Cabellos G., Borremans B., van der Lelie D., Barac T., Oeyen L., Vangronsveld J., Porteous Moore F., Moore E.R.B., Campbell C.D., Ryan D. & Dowling D.N. 2004. FEMS Microbiol. Ecol. 48: 109–118.

    Article  CAS  PubMed  Google Scholar 

  • Harper J.K., Arif A.M., Ford E.J., Strobel G.A., Porco J.A., Tomer D.P., Oneill K.L., Heider E.M. & Grant D.M. 2003. Tetrahedron 59: 2471–2476.

    Article  CAS  Google Scholar 

  • Hormazabal E., Schmeda-Hirschmann G., Astudillo L., Rodriguez J. & Theoduloz C. 2005. Z. Naturforsch [C] 60: 11–21.

    CAS  Google Scholar 

  • Jadulco R., Brauers G., Edrada R.A., Ebel R., Wray V., Sudarsono V. & Proksch P. 2002. J. Nat. Prod. 65: 730–733.

    Article  PubMed  CAS  Google Scholar 

  • Janssen G.B., Beems R.B., Speijers G.J. & van Egmond H.P. 2000. Food Chem. Toxicol. 38: 679–688.

    Article  PubMed  CAS  Google Scholar 

  • Kingston D.G.I. 2001. Chem. Commun. 867–880.

  • Klemke C., Kehraus S., Wright A.D. & Konig G.M. 2004. J. Nat. Prod. 67: 1058–1053.

    Article  PubMed  CAS  Google Scholar 

  • Krohn K., Biele C., Drogies K.H., Steingrover K., Aust H.J., Draeger S. & Schulz B. 2002. Eur. J. Org. Chem. 2002: 2331–2336.

    Article  Google Scholar 

  • Kumar D.S., Lau S.C., Van J.M., Yang D. & Hyde K.D. 2005. Life Sci. 78: 147–156.

    Article  PubMed  CAS  Google Scholar 

  • Kunkel B.A., Grewal P.S. & Quigley M.F. 2004. Biol. Control 29: 100–108.

    Article  Google Scholar 

  • Leuchtmann A., Petrini O., Petrini L.E. & Carroll G.C. 1992. Mycol. Res. 96: 287–294.

    CAS  Google Scholar 

  • Li J.Y., Harper J.K., Grant D.M., Tombe B.O., Bashyal B., Hess W.M. & Strobel G.A. 2001. Phytochem. 56: 463–468.

    Article  CAS  Google Scholar 

  • Li J.Y. & Strobel G.A. 2001. Phytochem. 57: 261–265.

    Article  CAS  Google Scholar 

  • Li H.M., Sullivan R., Moy M., Kobayashi D.Y. & Belanger F.C. 2004. Mycologia 96: 526–536.

    CAS  Google Scholar 

  • Liu J.Y., Song Y.C., Zhang Z., Wang L., Guo Z.J., Zou W.X. & Tan R.X. 2004. J. Biotechnol. 114: 279–287.

    Article  PubMed  CAS  Google Scholar 

  • Ma Y.M., Li Y., Liu J.Y., Song Y.C. & Tan R.X. 2004. Fitoterapia 75: 451–456.

    Article  PubMed  CAS  Google Scholar 

  • Mercier J. & Jiménez J.I. 2004. Postharvest Biol. Technol. 31: 1–8.

    Article  Google Scholar 

  • Moy M., Li H.J.M., Sullivan R., White J.F. & Belanger F.C. 2002. Plant Physiol. 130: 1298–1308.

    Article  PubMed  CAS  Google Scholar 

  • Ohzeki T. & Mori K. 2003. Biosci. Biotechnol. Biochem. 67: 2584–2590.

    Article  PubMed  CAS  Google Scholar 

  • Park J.H., Choi G.J., Lee H.B., Kim K.M., Jung H.S., Lee S.W., Jang K.S., Cho K.Y. & Kim J.C. 2005. J. Microbiol. Biotechnol. 15: 112–117.

    CAS  Google Scholar 

  • Petrini L.E., Petrini O., Leuchtmann A. & Carroll G.C. 1991. Sydowia 43: 148–169.

    Google Scholar 

  • Petrini O., Sieber T.N., Toti L. & Viret O. 1992. Nat. Toxins 1: 185–196.

    Article  PubMed  CAS  Google Scholar 

  • Puri S.C., Nazir A., Chawla R., Arora R., Ryiaz-ul-Hasan S., Amna T., Ahmed B., Verma V., Singh S., Sagar R., Sharma A., Kumar R., Sharma R.K. & Quazi G.N. 2006. J. Biotechnol. (in press)

  • Puri S.C., Verma V., Amna T., Quazi G.N. & Spiteller M. 2005. J. Nat. Prod. 68: 1717–1719.

    Article  PubMed  CAS  Google Scholar 

  • Read D.J., Ducket J.G., Francis R., Ligron R. & Russell A. 2000. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 355: 815–830.

    Article  PubMed  CAS  Google Scholar 

  • Saikkonen K., Wäli P., Helander M. & Taeth S.H. 2004. Trends Plant Sci. 9: 275–280.

    Article  PubMed  CAS  Google Scholar 

  • Salituro G.M, Pelaez F. & Zhang B.B. 2001. Recent Prog. Horm. Res. 56: 107–126.

    Article  PubMed  CAS  Google Scholar 

  • Schardl C.L. 2001. Fungal Genet. Biol. 33: 69–82.

    Article  PubMed  CAS  Google Scholar 

  • Schulz B., Boyle C.H., Draeger S., Rommert A.K. & Krohn K. 2002. Mycol. Res. 106: 996–1004.

    Article  CAS  Google Scholar 

  • Schwarz M., Kopcke B., Weber R.W.S., Sterner O. & Anke H. 2004. Phytochem. 65: 2239–2245.

    Article  CAS  Google Scholar 

  • Scott B. 2001. Curr. Opin. Microbiol. 4: 393–398.

    Article  PubMed  CAS  Google Scholar 

  • Sieber T.N., Sieber-Canavesi F. & Dorworth C.E. 1991. Can. J. Bot. 69: 407–411.

    Google Scholar 

  • Song Y.C., Li H., Ye Y.H., Shan C.Y., Yang Y.M. & Tan R.X. 2004. FEMS Microbiol. Lett. 241: 67–72.

    Article  PubMed  CAS  Google Scholar 

  • Song Y.C., Huang W.Y., Sun C., Wang F.W. & Tan R.X. 2005. Biol. Pharm. Bull. 28: 506–509.

    Article  PubMed  CAS  Google Scholar 

  • Stamford T.L., Stamford N.P., Coelho L.C. & Araujo J.M. 2002. Bioresour. Technol. 83: 105–109.

    Article  PubMed  CAS  Google Scholar 

  • Strobel G.A., Stierle A., Stierle D. & Hess W.M. 1993. Mycotaxon. 47: 71–78.

    Google Scholar 

  • Strobel G., Ford E., Worapong J., Harper J.K., Arif A.M., Grant D.M., Fung P.C.W. & Chau R.M.W. 2002. Phytochem. 60: 179–183.

    Article  CAS  Google Scholar 

  • Strobel G.A. 2002. Can. J. Plant Pathol. 24: 14–20.

    Article  Google Scholar 

  • Strobel G.A. 2003. Microbes Infect. 5: 535–544.

    Article  PubMed  CAS  Google Scholar 

  • Strobel G.A. & Daisy B. 2003. Microbiol. Mol. Biol. Rev. 67: 491–502.

    Article  PubMed  CAS  Google Scholar 

  • Suto M., Takebayashi M., Saito K., Tanaka M., Yokota A. & Tomita F. 2002. J. Biosci. Bioeng. 93: 88–90.

    PubMed  CAS  Google Scholar 

  • Tan R.X. & Zou W.X. 2001. Nat. Prod. Rep. 18: 448–459.

    Article  PubMed  CAS  Google Scholar 

  • Tesar M., Reichenauer T.G. & Sessitsch A. 2002. Soil Biol. Biochem. 34: 1883–1892.

    Article  CAS  Google Scholar 

  • Wang J., Machado C., Panaccione D.G., Tsai H.F. & Schardl C.L. 2004. Fungal Genet. Biol. 41: 189–198.

    Article  PubMed  CAS  Google Scholar 

  • Weber R.W., Stenger E., Meffert A. & Hahn M. 2004a. Mycol. Res. 108: 662–671.

    Article  PubMed  CAS  Google Scholar 

  • Weber D., Sterner O., Anke T., Gorzalczancy S., Martino V. & Acevedo C. 2004b. J. Antibiot. (Tokyo) 57: 559–563.

    CAS  Google Scholar 

  • Wiyakrutta S., Sriubolmas N., Panphut W., Thongon N., Danwisetkanjana K., Ruangrungsi N. & Meevootisom V. 2004. World J. Microbiol. Biotechnol. 20: 265–272.

    Article  Google Scholar 

  • Zhao P.J., Fan L.M., Li G.H., Zhu N. & Shen Y.M. 2005. Arch. Pharm. Res. 28: 1228–1232.

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Silvia Firáková.

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Firáková, S., Šturdíková, M. & Múčková, M. Bioactive secondary metabolites produced by microorganisms associated with plants. Biologia 62, 251–257 (2007). https://doi.org/10.2478/s11756-007-0044-1

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