Endosc Int Open 2015; 03(04): E339-E345
DOI: 10.1055/s-0034-1391901
Original article
© Georg Thieme Verlag KG Stuttgart · New York

A single-center United States experience with bleeding Dieulafoy lesions of the small bowel: diagnosis and treatment with single-balloon enteroscopy

Seth Lipka
1   University of South Florida Morsani College of Medicine, Department of Medicine, Tampa, Florida, United States
,
Roshanak Rabbanifard
2   University of South Florida Morsani College of Medicine, Division of Digestive Diseases and Nutrition, Tampa, Florida, United States
,
Ambuj Kumar
3   University of South Florida Morsani College of Medicine, Department of Medicine, Division of Evidence Based Medicine and Outcomes Research, Tampa, Florida, United States
,
Patrick Brady
2   University of South Florida Morsani College of Medicine, Division of Digestive Diseases and Nutrition, Tampa, Florida, United States
› Author Affiliations
Further Information

Publication History

submitted 22 May 2014

accepted after revision 23 February 2015

Publication Date:
24 June 2015 (online)

Introduction: A Dieulafoy lesion (DL) of the small bowel can cause severe gastrointestinal bleeding, and presents a difficult clinical setting for endoscopists. Limited data exists on the therapeutic yield of treating DLs of the small bowel using single-balloon enteroscopy (SBE).

Methods: Data were collected from Tampa General Hospital a 1 018-bed teaching hospital affiliated with University of South Florida in Tampa, Florida. Patients were selected from a database of patients that underwent SBE from January 2010 – August 2013.

Results: Eight patients were found to have DL an incidence of 2.6 % of 309 SBE performed for obscure gastrointestinal bleeding. 7/8 were identified in the jejunum, with one found in the duodenum. The mean age of patients with DL was 71.5 years old. 6/8 patients were on some form of anticoagulant/antiplatelet agent. The primary modality of therapy employed was electrocautery, multipolar electrocoagulation in seven patients and APC (argon plasma coagulation) in one patient. In three patients, electrocoagulation was unsuccessful and hemostasis was achieved with clip placement. Three patients required repeat SBE with one found to have rebleeding from a failed clip with hemostasis achieved upon reapplication of one clip.

Conclusion: In our United States’ experience, SBE offers a reasonable therapeutic approach to treat DL of the small bowel with low rates of rebleeding, no adverse events, and no patient requiring surgery.

 
  • References

  • 1 Shimizu S, Tada M, Kawai K. Development of a new insertion technique in push-type enteroscopy. Am J Gastroenterol 1987; 82: 844-847
  • 2 Ell C, Remke S, May A et al. The first prospective controlled trial comparing wireless capsule endoscopy with push enteroscopy in chronic gastrointestinal bleeding. Endoscopy 2002; 34: 685-689
  • 3 Monkemuller K, Bellutti M, Fry LC et al. Enteroscopy. Best Pract Res Clin Gastroenterol 2008; 22: 789-811
  • 4 Takano N, Yamada A, Watabe H et al. Single-balloon versus double-balloon endoscopy for achieving total enteroscopy: a randomized, controlled trial. Gastrointest Endosc 2011; 73: 734-739
  • 5 Domagk D, Mensink P, Aktas H et al. Single- vs. double-balloon enteroscopy in small-bowel diagnostics: a randomized multicenter trial. Endoscopy 2011; 43: 472-476
  • 6 May A, Farber M, Aschmoneit I et al. Prospective multicenter trial comparing push-and-pull enteroscopy with the single- and double-balloon techniques in patients with small-bowel disorders. Am J Gastroenterol 2010; 105: 575-581
  • 7 Gallard T. Aneurysmes miliares de l’estomac, donnant lieu à des hématémèses mortelles [French]. Bull Soc Med Hôp Paris 1884; 1: 84-91
  • 8 Stark ME, Gostout CJ, Balm RK. Clinical features and endoscopic management of Dieulafoy’s disease. Gastrointest Endosc 1992; 38: 545-550
  • 9 Matuchansky C, Babin P, Abadie JC et al. Jejunal bleeding from a solitary large submucosal artery. Report of two cases. Gastroenterology 1978; 75: 110-113
  • 10 Goldenberg SP, DeLuca Jr VA , Marignani P. Endoscopic treatment of Dieulafoy’s lesion of the duodenum. Am J Gastroenterol 1990; 85: 452-454
  • 11 Dulic-Lakovic E, Dulic M, Hubner D et al. Bleeding Dieulafoy lesions of the small bowel: a systematic study on the epidemiology and efficacy of enteroscopic treatment. Gastrointest Endosc 2011; 74: 573-580
  • 12 Fisher L, Lee Krinsky M, Anderson MA et al. The role of endoscopy in the management of obscure GI bleeding. Gastrointest Endosc 2010; 72: 471-479
  • 13 Hartmann D, Eickhoff A, Tamm R et al. Balloon-assisted enteroscopy using a single-balloon technique. Endoscopy 2007; 39 (Suppl. 01) E276
  • 14 Bakka A, Rosseland AR. Massive gastric bleeding from exulceratio simplex (Dieulafoy). Acta Chir Scand 1986; 152: 285-288
  • 15 Peitsch W, Lange W, Schauer A. [Dieulafoy’s exulceratio simplex a rare but serious cause of acute upper gastrointestinal bleeding]. Dtsch Med Wochenschr 1987; 112: 1940-1942
  • 16 Pointner R, Schwab G, Konigsrainer A et al. Endoscopic treatment of Dieulafoy’s disease. Gastroenterology 1988; 94: 563-566
  • 17 Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 41–1991. A 76-year-old man with recurrent gastrointestinal bleeding. N Engl J Med 1991; 325: 1086-1096
  • 18 Farrell DJ, Bennett MK. Dieulafoy’s vascular malformation as a cause of large intestinal bleeding. J Clin Pathol 1992; 45: 363-366
  • 19 Jaspersen D, Korner T, Schorr W et al. Extragastric Dieulafoy’s disease as unusual source of intestinal bleeding. Esophageal visible vessel. Dig Dis Sci 1994; 39: 2558-2560
  • 20 Baettig B, Haecki W, Lammer F et al. Dieulafoy’s disease: endoscopic treatment and follow up. Gut 1993; 34: 1418-1421
  • 21 Parra-Blanco A, Takahashi H, Mendez Jerez PV et al. Endoscopic management of Dieulafoy lesions of the stomach: a case study of 26 patients. Endoscopy 1997; 29: 834-839
  • 22 Landaeta J, Paternina R. Efficacy of endoscopic treatment of Dieulafoy lesions of the small bowel. In: Proceedings from the Digestive Disease Week Annual Meeting; May 18–21, 2013: Abstract SA1665 2013
  • 23 Chen TH, Chiu CT, Lin WP et al. Application of double-balloon enteroscopy in jejunal diverticular bleeding. World J Gastroenterol 2010; 16: 5616-5620
  • 24 Prachayakul V, Deesomsak M, Aswakul P et al. The utility of single-balloon enteroscopy for the diagnosis and management of small bowel disorders according to their clinical manifestations: a retrospective review. BMC Gastroenterol 2013; 13: 103
  • 25 Paliwal M, Madan K et al. Small bowel Dieulafoy’s: diagnosis, management and coutcome. J Gastroenterol Hepatol 2011; 26: 249 Abstract 210
  • 26 Chung CS, Huang CT, Wang HP et al. Single-balloon enteroscopy for the management of a bleeding Dieulafoy lesion in the jejunal diverticulum. J Formos Med Assoc 2011; 110: 724-725
  • 27 Ciobanu L, Pascu O, Diaconu B et al. (2013) Bleeding Dieulafoy’s-like lesions of the gut identified by capsule endoscopy. World J Gastroenterol 2013; 19: 4823-4826
  • 28 Norton ID, Petersen BT, Sorbi D et al. Management and long-term prognosis of Dieulafoy lesion. Gastrointest Endosc 1999; 50: 762-767
  • 29 Chung IK, Kim EJ, Lee MS et al. Bleeding Dieulafoy’s lesions and the choice of endoscopic method: comparing the hemostatic efficacy of mechanical and injection methods. Gastrointest Endosc 2000; 52: 721-724
  • 30 Park CH, Sohn YH, Lee WS et al. The usefulness of endoscopic hemoclipping for bleeding Dieulafoy lesions. Endoscopy 2003; 35: 388-392
  • 31 Alis H, Oner OZ, Kalayci MU et al. (2009) Is endoscopic band ligation superior to injection therapy for Dieulafoy lesion?. Surg Endosc 2009; 23: 1465-1469
  • 32 Hwang JH, Fisher DA, Ben-Menachem T et al. The role of endoscopy in the management of acute non-variceal upper GI bleeding. Gastrointest Endosc 2012; 75: 1132-1138
  • 33 Katsinelos P, Paroutoglou G, Mimidis K et al. (2005) Endoscopic treatment and follow-up of gastrointestinal Dieulafoy’s lesions. World J Gastroenterol 2005; 11: 6022-6026
  • 34 Veldhuyzen van Zanten SJ, Bartelsman JF, Schipper ME et al. Recurrent massive haematemesis from Dieulafoy vascular malformations--a review of 101 cases. Gut 1986; 27: 213-222
  • 35 Mumtaz R, Shaukat M, Ramirez FC. Outcomes of endoscopic treatment of gastroduodenal Dieulafoy’s lesion with rubber band ligation and thermal/injection therapy. J Clin Gastroenterol 2003; 36: 310-314
  • 36 Juler GL, Labitzke HG, Lamb R et al. The pathogenesis of Dieulafoy’s gastric erosion. Am J Gastroenterol 1984; 79: 195-200
  • 37 Skok P. Endoscopic hemostasis in exulceratio simplex-Dieulafoy’s disease hemorrhage: a review of 25 cases. Endoscopy 1998; 30: 590-594
  • 38 Dy NM, Gostout CJ, Balm RK. Bleeding from the endoscopically-identified Dieulafoy lesion of the proximal small intestine and colon. Am J Gastroenterol 1995; 90: 108-111
  • 39 Kasapidis P, Georgopoulos P, Delis V et al. Endoscopic management and long-term follow-up of Dieulafoy’s lesions in the upper GI tract. Gastrointest Endosc 2002; 55: 527-531