CC BY-NC-ND 4.0 · Endosc Int Open 2022; 10(04): E291-E292
DOI: 10.1055/a-1776-7729
Editorial

In addition to free deep margins, R0 resection should be required for T1 colorectal cancers to inform further surgical resection

Naoya Toyoshima
Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan
,
Seiichiro Abe
Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan
,
Yutaka Saito
Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan
› Author Affiliations

Endoscopic treatment of T1 colorectal cancer (CRC) has become technically feasible with the development of various endoscopic treatment techniques, such as endoscopic submucosal dissection and endoscopic full-thickness resection. A recent study revealed that endoscopic resection of T1 CRCs is acceptable prior to considering open surgery [1]. A multicenter retrospective study from Japan showed favorable long-term outcomes for endoscopic resection in patients with T1 CRC and a low risk of lymph node metastasis (LNM) [2]. The National Comprehensive Cancer Network [NCCN] guidelines recommend additional surgical resection with lymph node dissection for any T1b CRC, given the potential risk of LNM [3].



Publication History

Article published online:
14 April 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • References

  • 1 Overwater A, Kessels K, Elias SG. et al. Endoscopic resection of high-risk T1 colorectal carcinoma prior to surgical resection has no adverse effect on long-term outcomes. Gut 2018; 67: 284-290
  • 2 Yoda Y, Ikematsu H, Matsuda T. et al. A large-scale multicenter study of long-term outcomes after endoscopic resection for submucosal invasive colorectal cancer. Endoscopy 2013; 45: 718-724
  • 3 National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology (NCCN Guidelines®) rectal cancer (Version 1.2017). 2017 Available from: https://www.nccn.org/professionals/physician_gls/f_guidelines.asp
  • 4 Labianca R, Nordlinger B, Beretta GD. et al. Early colon cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2013; 24: vi64-72
  • 5 Glimelius B, Tiret E, Cervantes A. et al. Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2013; 24: vi81-vi88
  • 6 Watanabe T, Muro K, Ajioka Y. et al. Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2016 for the treatment of colorectal cancer. Int J Clin Oncol 2018; 23: 1-34
  • 7 Butte JM, Tang P, Gonen M. et al. Rate of residual disease after complete endoscopic resection of malignant colonic polyp. Dis Colon Rectum 2012; 55: 122-127
  • 8 Gijsbers KM, van der Schee L. et al. The impact of > 0.1 mm free resection margins on local intramural residual cancer after local excision of T1 colorectal cancer. Endosc Int Open 2022; 10: 282-290
  • 9 Rönnow CF, Arthursson V, Toth E. et al. Lymphovascular infiltration, not depth of invasion, is the critical risk factor of metastases in early colorectal cancer: Retrospective population-based cohort study on prospectively collected data, including validation. Ann Surg 2022; 275: e148-e154
  • 10 Sakamoto T, Matsuda T, Otake Y. et al. Predictive factors of local recurrence after endoscopic piecemeal mucosal resection. J Gastroenterol 2012; 47: 635-640
  • 11 Uraoka T, Saito Y, Matsuda T. et al. Endoscopic indications for endoscopic mucosal resection of laterally spreading tumours in the colorectum. Gut 2006; 55: 1592-1597
  • 12 Takamaru H, Saito Y, Sekiguchi M. et al. Endoscopic resection before surgery does not affect the recurrence rate in patients with high-risk T1 colorectal cancer. Clin Transl Gastroenterol 2021; 12: e00336