Issue 8, 2009
From the journal:

Natural Product Reports

New natural product biosynthetic chemistry discovered by genome mining

Christophe Correa  and  Gregory L. Challis*a  

* Corresponding authors

a Department of Chemistry, University of Warwick, Coventry, UK
E-mail: g.l.challis@warwick.ac.uk
Fax: +44 (0) 2476 524112
Tel: +44 (0) 2476 574024

Abstract

Covering: 2000 to 2008

Analyses of plant and microbial genome sequences have revealed many genes and gene clusters encoding proteins similar to those known to be involved in the biosynthesis of structurally-complex natural products. Many of these genes and gene clusters do not direct the production of known metabolites of the organism in which they are found. Others represent novel gene clusters that direct the biosynthesis of known natural products. This article highlights several examples of new biosynthetic chemistry discovered in the course of investigating such gene clusters.

Graphical abstract: New natural product biosynthetic chemistry discovered by genome mining

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Article information

DOI
https://doi.org/10.1039/B713024B
Article type
Highlight
Submitted
13 Mar 2009
First published
22 May 2009

Nat. Prod. Rep., 2009,26, 977-986

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New natural product biosynthetic chemistry discovered by genome mining

C. Corre and G. L. Challis, Nat. Prod. Rep., 2009, 26, 977 DOI: 10.1039/B713024B

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