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Toxicology for the twenty-first century

The testing of substances for adverse effects on humans and the environment needs a radical overhaul if we are to meet the challenges of ensuring health and safety.

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Figure 1: The consequences of searching for rare hazards using imperfect tests.
Figure 2: Integrated testing strategy for eye and skin toxicity.
Figure 3: Towards a new toxicology.

References

  1. Taylor, K., Gordon, N., Langley, G. & Higgins, W. Altern. Lab. Anim. 36, 327–342 (2008).

    CAS  PubMed  Google Scholar 

  2. Hartung, T. ALTEX 25, 3–9 (2008).

    Article  PubMed  Google Scholar 

  3. http://iccvam.niehs.nih.gov/docs/acutetox_docs/ATpanelrpt06/ATpanelrpt.pdf

  4. Basketter, D. A., York, M., McFadden, J. P. & Robinson, M. K. Contact Dermatitis 51, 1–4 (2004).

    Article  CAS  PubMed  Google Scholar 

  5. Gottmann, E., Kramer, S., Pfahringer, B. & Helma, C. Environ. Health Perspect. 109, 509–514 (2001).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Schardein, J. L., Schwetz, B. A. & Kenel, M. F. Environ. Health Perspect. 61, 55–67 (1985).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Olson, H. et al. Regul. Toxicol. Pharmacol. 32, 56–67 (2000).

    Article  CAS  PubMed  Google Scholar 

  8. Stevens, J. L. Chem. Res. Toxicol. 19, 1393–1401 (2006).

    Article  CAS  PubMed  Google Scholar 

  9. Lazarou, J. J. Am. Med. Assoc. 279, 1200–1205 (1998).

    Article  CAS  Google Scholar 

  10. Rietjens, I. M. C. M. & Alink, G. M. Chem. Res. Toxicol. 19, 977–981 (2006).

    Article  CAS  PubMed  Google Scholar 

  11. Austin, P. C., Mamdani, M. M., Juurlink, D. N. & Hux, J. E. J. Clin. Epidemiol. 59, 964–969 (2006).

    Article  PubMed  Google Scholar 

  12. Purchase, I. F. H. Toxicology 202, 1–20 (2004).

    Article  CAS  PubMed  Google Scholar 

  13. Wandall, B., Hansson, S. O. & Rudén, C. Arch. Toxicol. 81, 605–617 (2007).

    Article  CAS  PubMed  Google Scholar 

  14. Hoffmann, S. & Hartung, T. Toxicol. Sci. 85, 422–428 (2005).

    Article  CAS  PubMed  Google Scholar 

  15. Hoffmann, S., Cole, T. & Hartung, T. Regul. Toxicol. Pharmacol. 41, 159–166 (2005).

    Article  CAS  PubMed  Google Scholar 

  16. Bremer, S., Pellizzer, C., Hoffmann, S., Seidle, T. & Hartung, T. Curr. Pharm. Des. 13, 3047–3058 (2007).

    Article  CAS  PubMed  Google Scholar 

  17. Höfer, T. et al. Arch. Toxicol. 78, 549–564 (2004).

    Article  PubMed  Google Scholar 

  18. Hartung, T. ALTEX 24, 143–147 (2007).

    Article  PubMed  Google Scholar 

  19. Hareng, L., Pellizzer, C., Bremer, S., Schwarz, M. & Hartung, T. Reprod. Toxicol. 20, 441–452 (2005).

    Article  CAS  PubMed  Google Scholar 

  20. Kola, I. & Landis, J. Nature Rev. Drug Discov. 3, 711–715 (2004).

    Article  CAS  Google Scholar 

  21. Kuiper, H. A. Plant J. 27, 503–528 (2001).

    Article  CAS  PubMed  Google Scholar 

  22. Service, R. F. Science 321, 1036–1037 (2008).

    Article  CAS  PubMed  Google Scholar 

  23. Wood, M., Pichard, A., Gundert-Remy, U., de Rooij, C. & Tissot, S. M. J. Hazard. Mater. 133, 8–15 (2006).

    Article  CAS  PubMed  Google Scholar 

  24. http://www.cochrane.org/

  25. Hoffmann, S. & Hartung, T. Hum. Exp. Toxicol. 25, 497–513 (2006).

    Article  CAS  PubMed  Google Scholar 

  26. Hansson, S. O. & Ruden, C. Toxicology 218, 100–111 (2006).

    Article  CAS  PubMed  Google Scholar 

  27. Davila, J. C. et al. Toxicol. Sci. 79, 214–223 (2004).

    Article  CAS  PubMed  Google Scholar 

  28. Stummann, T. C. & Bremer, S. Curr. Stem Cell Res. Ther. 3, 117–130 (2008).

    Article  CAS  Google Scholar 

  29. Hartung, T. & Leist, M. ALTEX 25, 91–96 (2008).

    Article  PubMed  Google Scholar 

  30. Leist, M., Hartung, T. & Nicotera, P. ALTEX 25, 103–114 (2008).

    Article  PubMed  Google Scholar 

  31. MacGregor, J. T. Toxicol. Sci. 75, 236–248 (2003).

    Article  CAS  PubMed  Google Scholar 

  32. Pognan, F. Pharmacogenomics 5, 879–893 (2004).

    Article  CAS  PubMed  Google Scholar 

  33. Lotti, M. & Nicotera, P. Nature 416, 481 (2002).

    Article  CAS  ADS  PubMed  Google Scholar 

  34. Orrhenius, S. & Zhitvotovsky, B. Chem. Res. Toxicol. 19, 729–733 (2006).

    Article  Google Scholar 

  35. Committee on Toxicity Testing and Assessment of Environmental Agents, Board on Environmental Studies and Toxicology, Institute for Laboratory Animal Research, National Research Council of the National Academies. Toxicity Testing in the 21st Century: a Vision and a Strategy (The National Academies Press, 2007).

  36. Collins, F. S., Gray, G. M. & Bucher, J. R. Science 319, 906–907 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. http://www.epa.gov/osa/spc/toxicitytesting/

  38. http://www.epa.gov/ncct/toxcast/

  39. Hartung, T. ALTEX 25, 147–162 (2008).

    Article  PubMed  Google Scholar 

  40. Bottini, A. A. & Hartung, T. ALTEX 26, 3–16 (2008).

    Google Scholar 

  41. Hartung, T. Altern. Lab. Anim. 36, 635–639 (2008).

    CAS  PubMed  Google Scholar 

  42. Hartung, T. Toxicol. Sci. 109, 18–23 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

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Hartung, T. Toxicology for the twenty-first century. Nature 460, 208–212 (2009). https://doi.org/10.1038/460208a

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