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Signalling through the lipid products of phosphoinositide-3-OH kinase

Nature volume 387, pages 673–676 (1997)Cite this article

Abstract

When a stimulatory agonist molecule binds at the exterior of the cell membrane, a second messenger transduces the signal to the interior of the cell. Second messengers can be derived from phospholipids in the membrane by the action of the enzymes phospholipase C or phosphoinositide-3-OH kinase (PI(3)K). PI(3)K is a key player in many cellular responses, including the movement of organelle membranes, shape alteration through rearrangement of cytoskeletal actin, transformation and chemotaxis. But how PI(3)K mediates these responses is only now becoming clear.

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Figure 1: Pathways for phosphoinositide synthesis.
Figure 2: Proteins known to bind phosphoinositides in vitro: possible roles incellular responses.

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Authors and Affiliations

  1. Boston Biomedical Research Institute, 20 Staniford Street, Boston, 02114, Massachusetts, USA

    Alex Toker

  2. Department of Cell Biology, Harvard Medical School and Division of Signal Transduction, Beth Israel Deaconess Medical Center, 330 Brook line Avenue, Boston, 02115, Massachusetts, USA

    Lewis C. Cantley

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Toker, A., Cantley, L. Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature 387, 673–676 (1997). https://doi.org/10.1038/42648

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