The neurochemical coding and projections of circular muscle motor neurons in the human colon
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Types of Neurons in the Human Colonic Myenteric Plexus Identified by Multilayer Immunohistochemical Coding
2023, Cellular and Molecular Gastroenterology and HepatologyThe role of enteric inhibitory neurons in intestinal motility
2021, Autonomic Neuroscience: Basic and ClinicalCitation Excerpt :By removing a section of myenteric plexus (“myectomy”) and observing the degeneration of immunoreactive nerve fibres in the muscle, inhibitory motor neurons were shown to be located in myenteric ganglia, at least in small laboratory animals (Brookes and Costa, 1990). Later, it was shown in larger species, including humans, that some circular muscle inhibitory motor neurons are located in the external submucous ganglia (Wilson et al., 1987; Brookes and Costa, 1990; Porter et al., 1997). Analysis of projections of IMNs was also investigated, by making single cuts or pairs of cuts through the muscle layers (“myotomies”) and observing degeneration of axons by immunohistochemical or electrophysiological means (Bornstein et al., 1986; Costa et al., 1992; Portbury et al., 1995; Brookes, 2001;).
Disrupted local innervation results in less VIP expression in CF mice tissues
2021, Journal of Cystic FibrosisCitation Excerpt :Also, in both ileum and duodenum it stimulates ion transport and mucus secretion [13–17]. The expression of VIP in the intrinsic neuronal network of the gut of mammals has been widely demonstrated [18–30]. In the upper small intestine, mucosa and circular muscle layer are characterized by high density of VIP-positive nerve fibers as well as smooth muscles layers across all GI regions [31].
Robust, 3-Dimensional Visualization of Human Colon Enteric Nervous System Without Tissue Sectioning
2020, GastroenterologyCitation Excerpt :Because most myenteric neurons produce either nitric oxide or acetylcholine,2 we focused on these subgroups. We found little between-subject variability in noncholinergic nNOS+ neuron prevalence (approximately 50% of myenteric neurons) similar to prior reports indicating 43%–54% of human myenteric neurons were ChAT–/nNOS+ (Supplementary Table 5).36–39,66–69 Also consistent with past studies reporting 3%–10% of human colon myenteric neurons produce nNOS and ChAT, we scored 4%–6% of myenteric neurons as nNOS+/cholinergic.
Neurophysiologic Mechanisms of Human Large Intestinal Motility
2018, Physiology of the Gastrointestinal Tract, Sixth EditionEnteric Nervous System Structure and Neurochemistry Related to Function and Neuropathology
2018, Physiology of the Gastrointestinal Tract, Sixth Edition