Original ArticleThe Mediating Role of Physical Inactivity on the Relationship between Inflammation and Artery Thickness in Prepubertal Adolescents
Section snippets
Methods
The data presented in this study were collected from the baseline measures of a cohort study, which is being carried out in the city of Presidente Prudente (200 000 inhabitants; western Sao Paulo State, Brazil). This study started in the second half of 2013 and has follow-up measures scheduled for the second half of 2014 (August/September). Before data collection, the minimum sample size was calculated11 based on previous data about the expected relationship between cIMT and hsCRP (r = 0.28,
Results
The characteristics of the adolescents stratified according to hsCRP tertiles are presented in Table I. Maturity offset ranged from −6.07 years to −0.86 years to APHV and sports practice was reported by 50% (95% CI 41.1%-58.9%) of the sample. Among the adolescents who engaged in organized sports participation, the number of steps/day was marginally related to HDL-c (r = 0.24 [−0.01 to 0.46]).
Adolescents with grater hsCRP had increased values of body mass (P = .001), body mass index (P = .001),
Discussion
In these adolescents, inflammatory markers and trunk fatness were significantly related. This finding is particularly interesting because this relationship occurred before the growth spurt.16 This finding is potentially concerning because the natural increase of adipose tissue observed throughout maturational events16 might exacerbate the harmful relationship between body fatness and inflammation already present during adolescence.17, 18 Inflammation is commonly related to increased body
References (29)
eNOS. Metabolic syndrome and cardiovascular disease
Trends Endocrinol Metab
(2009)The effect of physical exercise on reverse cholesterol transport
Metabolism
(2003)- et al.
Protection by physical activity against deleterious effect of smoking on carotid intima-media thickness in young Japanese
J Stroke Cerebrovasc Dis
(2013) - et al.
Induction of epigenetic alterations by dietary and other environmental factors
Adv Genet
(2010) - et al.
Circulating activated endothelial cells in pediatric obesity
J Pediatr
(2010) - et al.
Exercise training is not associated with improved levels of C-reactive protein or adiponectin
Metabolism
(2005) - et al.
Mechanisms linking obesity with cardiovascular disease
Nature
(2006) - et al.
Childhood C-reactive protein in predicting CRP and carotid intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study
Arterioscler Thromb Vasc Biol
(2006) - et al.
Nutrition, physical activity, and cardiovascular disease: an update
Cardiovasc Res
(2007) - et al.
Effect of regular physical activity on carotid intima-media thickness. Results from a 6-year prospective study in the early stage of hypertension
Blood Press
(2011)
Endothelial wall thickness, cardiorespiratory fitness and inflammatory markers in obese and non-obese adolescents
Braz J Phys Ther
Association of physical activity with vascular endothelial function and intima-media thickness
Circulation
Cigarette smoking exacerbates the adverse effects of age and metabolic syndrome on subclinical atherosclerosis: the Bogalusa Heart Study
PLoS One
Sample size in clinical and experimental trials
J Vasc Bras
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Funded by the State of São Paulo Research Support Foundation (FAPESP [Process: 2013/06052-2]) and CNPq (Process: 476295/2013-0). The authors declare no conflicts of interest.