Immunity
Volume 38, Issue 1, 24 January 2013, Pages 1-3
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The CD70-CD27 Axis, a New Brake in the T Helper 17 Cell Response

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The CD70-CD27 interaction is known to positively regulate T cell expansion and effector function by providing costimulatory signals. In this issue of Immunity, Coquet et al. (2013) show an unexpected T-helper-17-cell-specific negative regulation mediated by CD70-CD27 interaction.

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