Short communicationA novel ladder-like lectin relates to sites of mucosal immunity in Atlantic halibut (Hippoglossus hippoglossus L.)
Section snippets
Acknowledgements
Thanks to Birgir Kristjánsson and the staff at Fiskeldi Eyjafjardar, þorlákshöfn, Iceland, and the staff at Fiskey hf, Hjalteyri, Iceland for providing the fish and sampling facilities. Thanks to Sigurður Helgason, Gísli Jónsson and Margrét Jónsdóttir, Keldur, Institute for Experimental Pathology University of Iceland for help with preparation of larval samples. Thanks also to Kevin Baily, University of Nottingham, U.K. for mass-spec analysis. This work was supported in parts by the EC grant
References (36)
- et al.
Humoral immune parameters of cultured Atlantic halibut (Hippoglossus hippoglossus L.)
Fish Shellfish Immunol.
(2001) - et al.
Isolation and characterization of complement component C3 from Atlantic cod (Gadus morhua L.) and Atlantic halibut (Hippoglossus hippoglossus L.)
Fish Shellfish Immunol.
(2004) - et al.
An immunohistochemical study on complement component C3 in juvenile Atlantic halibut (Hippoglossus hippoglossus L.)
Dev. Comp. Immunol.
(2004) - et al.
Complement component C3 transcription in Atlantic halibut (Hippoglossus hippoglossus L.) larvae
Fish Shellfish Immunol.
(2006) - et al.
Ontogeny of humoral immune parameters in fish
Fish Shellfish Immunol.
(2005) - et al.
Structural and functional diversity of the lectin repertoire in teleost fish: relevance to innate and adaptive immunity
Dev. Comp. Immunol.
(2011) - et al.
Complement in health and disease
Adv. Drug Deliv. Rev.
(2011) - et al.
The ontogeny of complement component C3 in Atlantic Cod (Gadus morhua L.)—an immunohistochemical study
Fish Shellfish Immunol.
(2004) - et al.
The ontogenic transcription of complement component C3 and Apolipoprotein A-I tRNA in Atlantic cod (Gadus morhua L.) - a role in development and homeostasis?
Dev. Comp. Immunol.
(2005) Which came first, the lectin/classical pathway or the alternative pathway of complement?
Immunobiology
(2002)
Lectin complement system and pattern recognition
Immunobiology
Evolutionary conservation of mannan-binding lectin (MBL) in bony fish: identification, characterization and expression analysis of three bona fide collectin homologues of MBL in the rainbow trout (Onchorhynchus mykiss)
Fish Shellfish Immunol.
Proteome reference map of the skin mucus of Atlantic cod (Gadus morhua) revealing immune competent molecules
Fish Shellfish Immunol.
A rainbow trout lectin with multimeric structure
Comp. Biochem. Physiol. B Biochem. Mol. Biol.
Cloning, binding properties, and tissue localization of rainbow trout (Oncorhynchus mykiss) ladderlectin
Fish Shellfish Immunol.
Molecular diversity of skin mucus lectins in fish
Comp. Biochem. Physiol. B Biochem. Mol. Biol.
Demonstration of the mucosal lectins in the epithelial cells of internal and external body surface tissues in pufferfish (Fugu rubripes)
Dev. Comp. Immunol.
Galectins in channel catfish, Ictalurus punctatus: characterization and expression profiling in mucosal tissues
Fish Shellfish Immunol.
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2022, Fish and Shellfish ImmunologyCitation Excerpt :This ladderlectin was first described as a Sepharose-binding protein that migrated as a ladder-like band on non-reducing PAGE and was a single 16 kDa monomer following reduction [9]. After that, ladderlectin was found in mucosal surfaces on gill and intestine in healthy rainbow trout and Atlantic halibut [10,11]. Ladderlectin expression was significantly increased in mucosal tissues of infected rainbow trout compared to healthy rainbow trout [12].
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2021, Comparative Biochemistry and Physiology - Part D: Genomics and ProteomicsCitation Excerpt :The key DEU ladderlectin, a gene encoding an extracellular CTLD protein has been suggested to be vital in pathogen clearance because of its ability to opsonize bacteria and viruses (Young et al., 2007; Russell et al., 2008). Although the function of ladderlectins in marine invertebrates remains underexplored, it is possible that observed upregulation confers enhanced immunity in SHO, as reported in fish species (Russell et al., 2008; Magnadottir et al., 2019). A DMBT1-like gene was also differentially expressed between STU and SHO.
A C-type lectin with a single CRD from Onychostoma macrolepis mediates immune recognition against bacterial challenge
2021, Fish and Shellfish ImmunologyCitation Excerpt :C-type lectins (CTLs) PRRs, depending on their capacity to bind specific carbohydrates on the surface of microbes in a Ca2+-dependent manner, play essential roles in the innate immunity of both vertebrates and invertebrates [3–5]. CTL family also includes proteins that contain domains similar to C-type domain (CTLD/CRD) [6,7]. The first C-type lectin has been discovered since more than 100 years [8,9] whose characteristics, structures and functions have been deeply and extensively studied up to now.
Extracellular vesicles from cod (Gadus morhua L.) mucus contain innate immune factors and deiminated protein cargo
2019, Developmental and Comparative ImmunologyCitation Excerpt :It is here reported for the first time as deiminated in mucosal EVs. Galectins are known to be strongly expressed in mucosal tissues in fish (Rajan et al., 2013a, 2013b; Vasta et al., 2004; Vasta, 2016; Zhou et al., 2016; Magnadottir et al., 2019b) and have a wide range of function in innate immunity, including against viral and bacterial infections (Chen et al., 2013; Nita-Lazar et al., 2017). Galectins are involved in many pathological processes, including acute and chronic inflammatory diseases, autoimmunity (Sciacchitano et al., 2018), tumours, as well as wound healing (McLeod et al., 2018).