Antimicrobial Susceptibility Studies
Acquisition of the mcr-1 gene by a high-risk clone of KPC-2-producing Klebsiella pneumoniae ST437/CC258, Brazil

https://doi.org/10.1016/j.diagmicrobio.2017.09.016Get rights and content
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Highlights

  • The coexistence of mcr-1 and carbapenem resistance genes is of great concern.

  • K. pneumoniae isolates carrying both mcr-1 and blaKPC genes are still rare in the world and it was only very recently described in Brazil.

  • The mcr-1 in KPC-producing “high-risk” clones such as ST 437 may foster the dissemination of colistin and carbapenem-resistant isolates determined by the feared mcr-1/ blaKPC combination.

Abstract

We identified one clinical isolate of K. pneumoniae harboring the mcr 1 (plasmid of IncX4 family) and blaKPC-2 (plasmid of IncFIB family) genes in southern Brazil. These findings highlight that K. pneumoniae isolates carrying both mcr-1 and blaKPC-2 may emergence as a serious threat to antimicrobial therapy.

Keywords

Resistance genes
Klebsiella pneumoniae
Colistin
Carbapenems

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