Natural autoantibodies

https://doi.org/10.1016/0952-7915(95)80053-0Get rights and content

Abstract

Autoantibodies of the IgM, IgG and IgA classes, reactive with a variety of serum proteins, cell surface structures and intracellular structures, are ‘naturally’ found in all normal individuals. Present in human cord blood and in ‘antigen-free’ mice, their variable-region repertoire is selected by antigenic structures in the body and remains conserved throughout life. Encoded by germline genes with no, or few, mutations, natural autoantibodies are characteristically ‘multireactive’ and do not undergo affinity maturation in normal individuals. Natural autoantibodies may participate in a variety of physiological activities , from immune regulation, homeostasis and repertoire selection, to resistance to infections, transport and functional modulation of biologically active molecules.

References (90)

  • A Sundblad et al.

    Stimulation of B and T cells by in vivo high dose immunoglobulin administration in normal mice

    J Autoimmun

    (1991)
  • D Amran et al.

    Suppression of cytokine-dependent human T-cell proliferation by intravenous immunoglobulin

    Clin Immunol Immunopath

    (1994)
  • L Mouthon et al.

    Invariance and restriction toward a limited set of self-antigens characterize neonatal IgM antibody repertoires and prevail in autoreactive repertoires of healthy adults

    Proc Natl Acad Sci USA

    (1995)
  • A Berneman et al.

    Natural mouse IgG reacts with self antigens including molecules involved in the immune response

    Eur J Immunol

    (1992)
  • P Minoprio et al.

    Most B cells in acute Trypanosoma cruzi infection lack parasite specificity

    Scand J Immunol

    (1988)
  • A Grandien et al.

    Endogenous VH-gene families expression in immunoglobulin-transgenic mice: evidence for selection of antibody repertoires

    Int Immunol

    (1991)
  • A Grandien et al.

    Positive and negative selection of antibody repertoires during B-cell differentiation

    Immunol Rev

    (1994)
  • D Portnoï et al.

    Immunocompetent autoreactive B lymphocytes are activated cycling cells in normal mice

    J Exp Med

    (1986)
  • A Grandien et al.

    Negative selection of multireactive B cell clones in normal adult mice

    Eur J Immunol

    (1994)
  • A Nobrega et al.

    Global analysis of antibody repertoires. II. Evidence for specificity, self-selection and the immunological ‘humunculus’ of antibodies in normal serum

    Eur J Immunol

    (1993)
  • L Mouthon et al.

    Analysis of the normal human IgG antibody repertoire. Evidence that IgG autoantibodies of healthy adults recognize a limited and conserved set of protein antigens in homologous tissues

    J Immunol

    (1995)
  • S Avrameas et al.

    The natural autoantibodies system: between hypotheses and facts

    Mol Immunol

    (1993)
  • S Lacroix-Desmazes et al.

    Analysis of the natural human IgG repertoire; life long stability of reactivities towards self antigens contrasts with age-dependent diversification of reactivities against bacterial antigens

    Eur J Immunol

    (1995)
  • F Huetz et al.

    Autoimmunity: the moving boundaries between physiology and pathology

    J Autoimmun

    (1988)
  • S Avrameas

    Natural autoantibodies: from ‘horror autotoxicus’ to ‘gnothi seauton’

    Immunol Today

    (1991)
  • F Rossi et al.

    Anti-idiotypes against autoantibodies in pooled normal human polyspecific immunoglobulins

    J Immunol

    (1989)
  • V Hurez et al.

    Anti-CD4 activity of normal immunoglobulin G for therapeutic use (IVIg)

    Ther Immunol

    (1994)
  • IR Cohen et al.

    Autoimmunity, microbial immunity and the immunological homunculus

    Immunol Today

    (1991)
  • Y Ichiyoshi et al.

    Analysis of the structural correlates for antibody polyreactivity by multiple reassortments of chimeric human immunoglobulin heavy and light chain V segments

    J Exp Med

    (1994)
  • ZJ Chen et al.

    Antigen-binding B cells and polyreactive antibodies

    Eur J Immunol

    (1995)
  • D Girard et al.

    Anti-microfilament IgG antibodies in normal adults and in patients with autoimmune disease: immunofluorescence and immunoblotting analysis of 201 subjects reveals polyreactivity with microfilament-associated proteins

    Clin Immunol Immunopath

    (1995)
  • DM Klinman et al.

    Cross-reactivity of IgG anti-DNA-secreting B cells in patients with systemic lupus erythematosus

    Eur J Immunol

    (1994)
  • SJ Thorpe et al.

    Human monoclonal rheumatoid factors: incidence of cross-rections with tissue components and correlation with VH gene usage

    Immunology

    (1994)
  • R Crouzier et al.

    Heavy chain variable region, light chain variable region, and heavy chain CDR3 influences on the mono- and polyreactivity and on the affinity of human monoclonal rheumatoid factors

    J Immunol

    (1995)
  • T Martin et al.

    Structure-function studies on a polyreactive (natural) autoantibody. Polyreactivity is dependent on somatically generated sequences in the third complementarity-determining region of the antibody heavy chain

    J Immunol

    (1994)
  • D Holmberg et al.

    Reactions among IgM antibodies derived from normal, neonatal mice

    Eur J Immunol

    (1984)
  • M Adib et al.

    IgG autoantibody activity in normal mouse serum is controlled by IgM

    J Immunol

    (1990)
  • F Rossi et al.

    Idiotypic interactions between normal human polyspecific IgG and natural IgM antibodies

    Eur J Immunol

    (1990)
  • L Mouthon et al.

    Immunomodulation of autoimmune and systemic inflammatory disorders with intravenous immunoglobulin

    Vox Sang

    (1994)
  • B Guibert et al.

    Naturally occuring antibodies against nine common antigens in human sera. I. Detection, isolation and characterization

    J Immunol

    (1982)
  • V Hurez et al.

    Expression and control of the natural autoreactive IgG repertoire in normal human serum

    Eur J Immunol

    (1993)
  • N Ronda et al.

    Analysis of natural and disease-associated autoantibody repertoires: anti-endothelial cell IgG autoantibody activity in the serum of healthy individuals and patients with systemic lupus erythematosus

    Int Immunol

    (1994)
  • F Huetz et al.

    T cell dependence of ‘natural’ autoreactive B cell activation in the spleen of normal mice

    Eur J Immunol

    (1988)
  • P Lymberi et al.

    Natural autoantibodies in nude and normal outbred (Swiss) and inbred (BALB/c) mice

    J Autoimmun

    (1989)
  • E Malanchere et al.

    Studies on the T cell dependence of natural IgM and IgG antibody repertoires in adult mice

    Eur J Immunol

    (1995)

    • Cited by (556)

    • Highly pathogenic natural monoclonal antibody B4-IgM recognizes a post-translational modification comprised of acetylated N-terminal methionine followed by aspartic or glutamic acid

      2023, Molecular Immunology

    • Provision of black soldier fly larvae (Hermetia illucens) in different ways benefits broiler welfare and performance, with largest effects of scattering live larvae

      2022, Physiology and Behavior

    • Serum autoantibodyome reveals that healthy individuals share common autoantibodies

      2022, Cell Reports

    • Induced antigen-binding polyreactivity in human serum IgA

      2022, Immunobiology

    • Natural Autoantibodies in Health and Disease

      2022, Comprehensive Pharmacology

    • Aberrant Activation of Immune and Non-Immune Cells Contributes to Joint Inflammation and Bone Degradation in Rheumatoid Arthritis

      2023, International Journal of Molecular Sciences
    View all citing articles on Scopus
    View full text
    Copyright © 1995 Published by Elsevier Ltd.