Regulation of expression of carbohydrate blood group antigens

doi:10.1016/0300-9084(88)90295-7

Biochimie

Volume 70, Issue 11, November 1988, Pages 1597-1611

https://doi.org/10.1016/0300-9084(88)90295-7 Get rights and content

Abstract

The carbohydrate antigens associated with the human ABO and Lewis blood group systems are excellent models for the study of the genetic regulation of glycoconjugate biosynthesis because their expression on erythrocytes and in saliva has been thoroughly investigated in terms of classical genetics and the chemical structures and pathways for the formation of the antigens are now well understood. The primary protein products of the blood group genes are believed to the glycosyltransferase enzymes that complete the biosynthesis of the determinants. The important controlling factors still to be elucidated are the genetic and environmental influences leading to the tissue specific expression of these antigens. The 3 types of regulation mechanisms discussed in this review are those arising: 1) from the specificity requirements of the glycosyltransferases encoded by the blood group genes; 2) from the competition or co-operation of glycosyltransferases encoded by genes at the same or independent loci; and 3) from the existence and tissue distribution of glycosyltransferases with related, but not identical, substrate specificities.

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Regulation of expression of carbohydrate blood group antigens

Abstract

Blood Groups in Man

Blood Groups in Man

Biochemistry

Adv. Hum. Genet.

Zbl. Bakteriol.

Z. Gesamte Exp. Med.

Immuno Forsch.

Acta Soc. Med. Fenn. Duodecim Ser. A

J. Exp. Med.

J. Exp. Med.

J. Natl. Cancer Inst.

Nature (London)

Blood Groups and Transfusion

Nature (London)

Acta Pathol. Microbiol. Scand.

Acta Pathol. Microbiol. Scand.

Nature (London)

Science

Adv. Enzymol.

Nature (London)

Eur. J. Biochem.

J. Biol. Chem.

Vox Sang.

Adv. Enzymol.

J. Biol. Chem.

Vox Sang.

FEBS Lett.

Eur. J. Biochem.

Eur. J. Biochem.

Biochem. Biophys. Acta

Methods Enzymol.

J. Biol. Chem.

Sub-cell. Biochem.

J. Biol. Chem.

J. Biol. Chem.

FEBS Lett.

FEBS Lett.

J. Biol. Chem.