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Physical activity in women with subclinical hypothyroidism

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Abstract

Purpose

Physical activity is associated with many health-related benefits. However, there is a shift towards inactive lifestyles around the world. Subclinical hypothyroidism (SCH) may have adverse effects similar to hypothyroidism. The presence of symptoms and reduced physical performance in SCH may contribute to an inactive lifestyle. Therefore, the present study aimed to compare physical activity levels (PALs) between women with subclinical hypothyroidism and healthy controls.

Methods

Thirty-two women with newly diagnosed SCH and 28 healthy women were enrolled in this cross-sectional study. Arterial stiffness was evaluated by pulse wave velocity (PWV). Neuromuscular symptoms were questioned. Participants wore a physical activity monitor (SenseWear® Armband) for 4 consecutive days. Handgrip and quadriceps muscle strength were assessed by dynamometer. Functional exercise capacity was assessed by 6-minute walk test (6MWT).

Results

There was no significant difference in sociodemographic variables between the groups. PWV was significantly higher in the SCH group (P = 0.006). Physical activity duration and number of steps were significantly lower in the SCH group (P < 0.05). There was significant difference in neuromuscular symptoms, handgrip and quadriceps muscle strength, and 6MWT distance between the groups (P < 0.05).

Conclusions

This study demonstrates that women with SCH had lower PALs compared to healthy controls. Women with SCH should participate in exercise programs to increase physical activity and muscle strength to achieve adequate PALs.

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References

  1. Pearce SH, Brabant G, Duntas LH, Monzani F, Peeters RP, Razvi S, Wemeau JL (2013) 2013 ETA guideline: management of subclinical hypothyroidism. Eur Thyroid J 2(4):215–228. https://doi.org/10.1159/000356507

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Tunbridge WM, Evered DC, Hall R, Appleton D, Brewis M, Clark F, Evans JG, Young E, Bird T, Smith PA (1977) The spectrum of thyroid disease in a community: the Whickham survey. Clin Endocrinol (Oxf) 7(6):481–493. https://doi.org/10.1111/j.1365-2265.1977

    Article  CAS  Google Scholar 

  3. Hollowell JG, Staehling NW, Flanders WD, Hannon WH, Gunter EW, Spencer CA, Braverman LE (2002) Serum TSH, T4, and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 87(2):489–499. https://doi.org/10.1210/jcem.87.2.8182

    Article  CAS  Google Scholar 

  4. Canaris GJ, Manowitz NR, Mayor G, Ridgway EC (2000) The Colorado thyroid disease prevalence study. Arch Intern Med 160(4):526–534. https://doi.org/10.1001/archinte.160.4.526

    Article  CAS  Google Scholar 

  5. Lankhaar JA, de Vries WR, Jansen JA, Zelissen PM, Backx FJ (2014) Impact of overt and subclinical hypothyroidism on exercise tolerance: a systematic review. Res Q Exerc Sport 85(3):365–389. https://doi.org/10.1080/02701367.2014.930405

    Article  PubMed  Google Scholar 

  6. Sorensen JR, Winther KH, Bonnema SJ, Godballe C, Hegedus L (2016) Respiratory manifestations of hypothyroidism: a systematic review. Thyroid 26(11):1519–1527. https://doi.org/10.1089/thy.2015.0642

    Article  PubMed  Google Scholar 

  7. Yen PM (2001) Physiological and molecular basis of thyroid hormone action. Physiol Rev 81(3):1097–1142. https://doi.org/10.1152/physrev.2001.81.3.1097

    Article  CAS  PubMed  Google Scholar 

  8. Decandia F (2018) Risk factors for cardiovascular disease in subclinical hypothyroidism. Ir J Med Sci 187(1):39–43. https://doi.org/10.1007/s11845-017-1617-9

    Article  CAS  PubMed  Google Scholar 

  9. Monzani F, Caraccio N, Del Guerra P, Casolaro A, Ferrannini E (1999) Neuromuscular symptoms and dysfunction in subclinical hypothyroid patients: beneficial effect of L-T4 replacement therapy. Clin Endocrinol (Oxf) 51(2):237–242. https://doi.org/10.1046/j.1365-2265.1999.00790

    Article  CAS  Google Scholar 

  10. Reuters VS, Teixeira Pde F, Vigario PS, Almeida CP, Buescu A, Ferreira MM, de Castro CL, Gold J, Vaisman M (2009) Functional capacity and muscular abnormalities in subclinical hypothyroidism. Am J Med Sci 338(4):259–263. https://doi.org/10.1097/MAJ.0b013e3181af7c7c

    Article  PubMed  Google Scholar 

  11. Caraccio N, Natali A, Sironi A, Baldi S, Frascerra S, Dardano A, Monzani F, Ferrannini E (2005) Muscle metabolism and exercise tolerance in subclinical hypothyroidism: a controlled trial of levothyroxine. J Clin Endocrinol Metab 90(7):4057–4062. https://doi.org/10.1210/jc.2004-2344

    Article  CAS  PubMed  Google Scholar 

  12. Sans S, Kesteloot H, Do Kromhout, Force T (1997) The burden of cardiovascular diseases mortality in Europe: Task Force of the European Society of Cardiology on Cardiovascular Mortality and Morbidity Statistics in Europe. Eur Heart J 18(8):1231–1248

    Article  PubMed  Google Scholar 

  13. Vlachopoulos C, Aznaouridis K, Stefanadis C (2010) Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. J Am Coll Cardiol 55(13):1318–1327. https://doi.org/10.1016/j.jacc.2009.10.061

    Article  Google Scholar 

  14. Van Sloten TT, Sedaghat S, Laurent S, London GM, Pannier B, Ikram MA, Kavousi M, Mattace-Raso F, Franco OH, Boutouyrie P (2015) Carotid stiffness is associated with incident stroke: a systematic review and individual participant data meta-analysis. J Am Coll Cardiol 66(19):2116–2125. https://doi.org/10.1016/j.jacc.2015.08.888

    Article  PubMed  Google Scholar 

  15. Caspersen CJ, Powell KE, Christenson GM (1985) Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. Public Health Rep 100(2):126–131. https://www.ncbi.nlm.nih.gov/pubmed/3920711

  16. Blair SN, Kohl HW 3rd, Paffenbarger RS Jr, Clark DG, Cooper KH, Gibbons LW (1989) Physical fitness and all-cause mortality. A prospective study of healthy men and women. JAMA 262(17):2395–2401. https://doi.org/10.1001/jama.1989.03430170057028

    Article  CAS  PubMed  Google Scholar 

  17. Mora S, Cook N, Buring JE, Ridker PM, Lee IM (2007) Physical activity and reduced risk of cardiovascular events: potential mediating mechanisms. Circulation 116(19):2110–2118. https://doi.org/10.1161/CIRCULATIONAHA.107.729939

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Sharif K, Watad A, Bragazzi NL, Lichtbroun M, Amital H, Shoenfeld Y (2018) Physical activity and autoimmune diseases: get moving and manage the disease. Autoimmun Rev 17(1):53–72. https://doi.org/10.1016/j.autrev.2017.11.010

    Article  CAS  PubMed  Google Scholar 

  19. Le Grande MR, Elliott PC, Worcester MU, Murphy BM, Goble AJ (2008) An evaluation of self-report physical activity instruments used in studies involving cardiac patients. J Cardiopulm Rehabil Prev 28(6):358–369. https://doi.org/10.1097/HCR.0b013e31818c3d90

    Article  PubMed  Google Scholar 

  20. Kowalski K, Rhodes R, Naylor PJ, Tuokko H, MacDonald S (2012) Direct and indirect measurement of physical activity in older adults: a systematic review of the literature. Int J Behav Nutr Phys Act 9(1):148. https://doi.org/10.1186/1479-5868-9-148

    Article  PubMed  PubMed Central  Google Scholar 

  21. Hwang MH, Yoo JK, Kim HK, Hwang CL, Mackay K, Hemstreet O, Nichols WW, Christou DD (2014) Validity and reliability of aortic pulse wave velocity and augmentation index determined by the new cuff-based SphygmoCor Xcel. J Hum Hypertens 28(8):475–481. https://doi.org/10.1038/jhh.2013.144

    Article  CAS  PubMed  Google Scholar 

  22. Lopez GA, Brond JC, Andersen LB, Dencker M, Arvidsson D (2018) Validation of SenseWear Armband in children, adolescents, and adults. Scand J Med Sci Sports 28(2):487–495. https://doi.org/10.1111/sms.12920

    Article  CAS  PubMed  Google Scholar 

  23. Mathiowetz V, Weber K, Volland G, Kashman N (1984) Reliability and validity of grip and pinch strength evaluations. J Hand Surg Am 9(2):222–226. https://doi.org/10.1016/S0363-5023(84)80146-X

    Article  CAS  PubMed  Google Scholar 

  24. Ee F (1992) Clinical assessment recommendations. Grip strength, 2nd edn. American Society of Hand Therapists, Chicago

    Google Scholar 

  25. Bohannon RW (1986) Test-retest reliability of hand-held dynamometry during a single session of strength assessment. Phys Ther 66(2):206–209. https://doi.org/10.1093/ptj/66.2.206

    Article  CAS  PubMed  Google Scholar 

  26. Laboratories ACoPSfCPF (2002) Statement AT: guidelines for the six-minute walking-test. Am J Respir Crit Care Med 166:111–117. https://doi.org/10.1164/ajrccm.166.1.at1102

    Article  Google Scholar 

  27. Enright PL, Sherrill DL (1998) Reference equations for the six-minute walk in healthy adults. Am J Respir Crit Care Med 158(5 Pt 1):1384–1387. https://doi.org/10.1164/ajrccm.158.5.9710086

    Article  CAS  PubMed  Google Scholar 

  28. Aksakoğlu G (2006) Sağlıkta araştırma ve çözümleme. Dokuz Eylül Üniversitesi Rektörlük Basımevi, İzmir, pp 215–223

    Google Scholar 

  29. Razvi S, Shakoor A, Vanderpump M, Weaver JU, Pearce SH (2008) The influence of age on the relationship between subclinical hypothyroidism and ischemic heart disease: a metaanalysis. J Clin Endocrinol Metab 93(8):2998–3007. https://doi.org/10.1210/jc.2008-0167

    Article  CAS  PubMed  Google Scholar 

  30. Ochs N, Auer R, Bauer DC, Nanchen D, Gussekloo J, Cornuz J, Rodondi N (2008) Meta-analysis: subclinical thyroid dysfunction and the risk for coronary heart disease and mortality. Ann Intern Med 148(11):832–845. https://doi.org/10.7326/0003-4819-148-11-200806030-00225

    Article  PubMed  Google Scholar 

  31. Teixeira PDFDS, Reuters VS, Ferreira MM, Almeida CP, Reis FAA, Buescu A, Costa AJL, Vaisman M (2008) Lipid profile in different degrees of hypothyroidism and effects of levothyroxine replacement in mild thyroid failure. Transl Res 151(4):224–231. https://doi.org/10.1016/j.trsl.2007.12.006

    Article  CAS  Google Scholar 

  32. Owen PJ, Rajiv C, Vinereanu D, Mathew T, Fraser AG, Lazarus JH (2006) Subclinical hypothyroidism, arterial stiffness, and myocardial reserve. J Clin Endocrinol Metab 91(6):2126–2132. https://doi.org/10.1210/jc.2005-2108

    Article  CAS  PubMed  Google Scholar 

  33. Nagasaki T, Inaba M, Kumeda Y, Hiura Y, Shirakawa K, Yamada S, Henmi Y, Ishimura E, Nishizawa Y (2006) Increased pulse wave velocity in subclinical hypothyroidism. J Clin Endocrinol Metab 91(1):154–158. https://doi.org/10.1210/jc.2005-1342

    Article  CAS  PubMed  Google Scholar 

  34. Van Remoortel H, Raste Y, Louvaris Z, Giavedoni S, Burtin C, Langer D, Wilson F, Rabinovich R, Vogiatzis I, Hopkinson NS, Troosters T, Consortium PR (2012) Validity of six activity monitors in chronic obstructive pulmonary disease: a comparison with indirect calorimetry. PLoS One 7(6):e39198. https://doi.org/10.1371/journal.pone.0039198

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Alharbi M, Bauman A, Neubeck L, Gallagher R (2017) Measuring overall physical activity for cardiac rehabilitation participants: a review of the literature. Heart Lung Circ 26(10):1008–1025. https://doi.org/10.1016/j.hlc.2017.01.005

    Article  PubMed  Google Scholar 

  36. Tudor-Locke C, Bassett DR (2004) How many steps/day are enough? Sports Med 34(1):1–8

    Article  PubMed  Google Scholar 

  37. Savcı FDS, Öztürk UFM, Arıkan FDH (2006) Üniversite öğrencilerinin fiziksel aktivite düzeyleri. Türk Kardiyol Dern Arfl 34(3):166–172

    Google Scholar 

  38. Brazeau AS, Beaudoin N, Belisle V, Messier V, Karelis AD, Rabasa-Lhoret R (2016) Validation and reliability of two activity monitors for energy expenditure assessment. J Sci Med Sport 19(1):46–50. https://doi.org/10.1016/j.jsams.2014.11.001

    Article  PubMed  Google Scholar 

  39. de Menezes Caceres V, Stocks N, Adams R, Haag DG, Peres KG, Peres MA, González-Chica DA (2018) Physical activity moderates the deleterious relationship between cardiovascular disease, or its risk factors, and quality of life: findings from two population-based cohort studies in Southern Brazil and South Australia. PLoS One 13(6):e0198769. https://doi.org/10.1371/journal.pone.0198769

    Article  CAS  Google Scholar 

  40. Bakrania K, Edwardson CL, Khunti K, Henson J, Stamatakis E, Hamer M, Davies MJ, Yates T (2017) Associations of objectively measured moderate-to-vigorous-intensity physical activity and sedentary time with all-cause mortality in a population of adults at high risk of type 2 diabetes mellitus. Prev Med Rep 5:285–288. https://doi.org/10.1016/j.pmedr.2017.01.013

    Article  PubMed  PubMed Central  Google Scholar 

  41. Metsamarttila E, Rodilla E, Jokelainen J, Herrala S, Leppaluoto J, Keinanen-Kiukaanniemi S, Herzig KH (2018) Effect of physical activity on pulse wave velocity in elderly subjects with normal glucose, prediabetes or type 2 diabetes. Sci Rep 8(1):8045. https://doi.org/10.1038/s41598-018-25755-4

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Bohannon RW (1998) Hand-grip dynamometry provides a valid indication of upper extremity strength impairment in home care patients. J Hand Ther 11(4):258–260. https://www.ncbi.nlm.nih.gov/pubmed/9862263

  43. Gallo D, Piantanida E, Veronesi G, Lai A, Sassi L, Lombardi V, Masiello E, Premoli P, Bianconi E, Cusini C, Rosetti S, Tanda ML, Toniolo A, Ferrario M, Bartalena L (2017) Physical performance in newly diagnosed hypothyroidism: a pilot study. J Endocrinol Invest 40(10):1099–1106. https://doi.org/10.1007/s40618-017-0661-7

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Graduate School of Health Sciences, Dokuz Eylül University, Izmir, Turkey

    A. Tanriverdi

  2. School of Physical Therapy and Rehabilitation, Dokuz Eylül University, Izmir, Turkey

    B. Ozcan Kahraman, S. Acar & S. Savci

  3. School of Physical Therapy and Rehabilitation, Ahi Evran University, Kirsehir, Turkey

    I. Ozsoy

  4. Department of Endocrinology and Metabolism, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey

    F. Bayraktar & B. Ozgen Saydam

  5. Department of Cardiology, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey

    E. Ozpelit & B. Akdeniz

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  1. A. Tanriverdi
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  2. B. Ozcan Kahraman
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Correspondence to A. Tanriverdi.

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All procedures performed in studies involving human participants were carried out in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

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Tanriverdi, A., Ozcan Kahraman, B., Ozsoy, I. et al. Physical activity in women with subclinical hypothyroidism. J Endocrinol Invest 42, 779–785 (2019). https://doi.org/10.1007/s40618-018-0981-2

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  • DOI: https://doi.org/10.1007/s40618-018-0981-2

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