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Role of miRNAs in hypoxia-related disorders

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Abstract

Hypoxia is a complex pathophysiological condition. The physiological and molecular responses to this stress have been extensively studied. However, the management of its ill effects still poses a challenge to clinicians. MicroRNAs (miRNAs) are short non-coding RNA molecules that control post-transcriptional gene expression. The regulatory role of miRNAs in hypoxic environments has been studied in many hypoxia-related disorders, however a comprehensive compilation and analysis of all data and the significance of miRNAs in hypoxia adaption is still lacking. This review summarizes the miRNAs related to various hypoxia-related disorders and highlights the computational approaches to study them. This would help in designing novel strategies toward efficient management of hypoxia-related disorders.

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  1. Defence Institute of Physiology and Allied Sciences (DIPAS), Defence R&D Organization (DRDO), Timarpur, Delhi, 110 054, India

    A Gupta, R Sugadev, Y K Sharma, Y Ahmad & P Khurana

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  1. A Gupta
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  2. R Sugadev
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Correspondence to P Khurana.

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Communicated by Ullas Kolthur-Seetharam.

Corresponding editor: Ullas Kolthur-Seetharam

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Gupta, A., Sugadev, R., Sharma, Y.K. et al. Role of miRNAs in hypoxia-related disorders. J Biosci 43, 739–749 (2018). https://doi.org/10.1007/s12038-018-9789-7

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