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Claustral structural connectivity and cognitive impairment in drug naïve Parkinson’s disease

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Abstract

The claustrum is a thin grey matter structure which is involved in a wide brain network. Previous studies suggested a link between claustrum and Parkinson’s Disease (PD), showing how α-synuclein pathology may affect claustral neurons as well as how α-synuclein immunoreactivity may correlate with the onset of cognitive dysfunctions. Our aim is to investigate, via diffusion MRI, claustral structural network changes in drug naïve PD patients, with the goal to understand whether such changes may contribute to cognitive decline in PD. 15 drug naïve PD patients and 15 age-matched controls were enrolled; MR protocol was performed on a 3T scanner. Whole brain probabilistic tractography was obtained using Constrained Spherical Deconvolution (CSD) diffusion model. Connectivity matrices were estimated based on a robust anatomical parcellation of structural T1w images. In PD group, impaired subnetworks were correlated with psychological examinations. We found decreased claustral connectivity in PD patients compared to controls, especially with areas mainly involved in visuomotor and attentional systems. Moreover, we found a positive correlation between MoCA and density of pathways connecting ipsilaterally claustrum to left (r = 0.578, p = 0.021) and right (r = 0.640, p = 0.020) Pars Orbitalis. Our results support the hypothesis of claustral involvement in cognitive decline in drug naïve PD patients.

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Author notes

  1. Alessandro Arrigo and Alessandro Calamuneri PhD equally contributed to the present work and are considered co-first authors.

Authors and Affiliations

  1. Department of Ophthalmology, IRCCS Ospedale San Raffaele, University Vita-Salute San Raffaele, Milan, Italy

    Alessandro Arrigo

  2. IRCCS Centro Neurolesi Bonino Pulejo, S.S. 113 – Contrada Casazza, 98124, Messina, Italy

    Alessandro Calamuneri, Demetrio Milardi, Francesco Corallo, Viviana Lo Buono, Gaetana Chillemi, Silvia Marino, Alberto Cacciola, Giuseppe Di Lorenzo & Angelo Quartarone

  3. Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy

    Alessandro Calamuneri & Enricomaria Mormina

  4. Department of Biomedical Sciences and Morphological and Functional Images, University of Messina, Messina, Italy

    Demetrio Milardi, Enricomaria Mormina, Michele Gaeta, Alberto Cacciola, Giuseppina Rizzo, Giuseppe Pio Anastasi & Angelo Quartarone

  5. NYU-Langone School of Medicine, New York, NY, USA

    Angelo Quartarone

  6. The Fresco Institute for Parkinson’s & Movement Disorders, New York, NY, USA

    Angelo Quartarone

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  1. Alessandro Arrigo
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Correspondence to Alessandro Calamuneri.

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Arrigo, A., Calamuneri, A., Milardi, D. et al. Claustral structural connectivity and cognitive impairment in drug naïve Parkinson’s disease. Brain Imaging and Behavior 13, 933–944 (2019). https://doi.org/10.1007/s11682-018-9907-z

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