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Incorporating pattern identification of chinese medicine into precision medicine: An integrative model for individualized medicine

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Abstract

On 20 January, 2015, U.S. President Obama announced an ambitious plan called "Precision Medicine (PM) Initiative", aiming to deliver geneticsbased medical treatments. PM has shown a promising prospect by tailoring disease treatments and preventions to individuals. However, a predominantly genetics-based method restricts its benefifit and applicability in most chronic and complex diseases. Pattern identification (PI) is one of the representative characteristics of Chinese medicine implying the concept of holism and individualized treatment. It is another classifification method taking environmental, psychosocial and other individual factors into account. Integrating PI with disease diagnosis of Western medicine will provide a strong complement to genetics-based PM, thus establish an integrative model for individualized medicine. PI provides new perspectives for PM, not only in clinical practice, but also in new drug development and clinical trial design. It is for sure that the integrative approach will ultimately lead to a safer, more convenient and effective patient-centered healthcare and most patients will benefifit in the era of PM.

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References

  1. Fox JL. Obama catapults patient-empowered Precision Medicine. Nat Biotechnol 2015;33:325.

    Article  CAS  PubMed  Google Scholar 

  2. Precision Medicine Initiative (PMI) Working Group Report to the Advisory Committee to the Director, NIH. The Precision Medicine Initiative Cohort Program–Building a Research Foundation for 21st Century Medicine, September 17, 2015.

  3. Reardon S. Precision-medicine plan raises hopes. Nature 2015;517:540.

    Article  CAS  PubMed  Google Scholar 

  4. Rubin R. Precision medicine: the future or simply politics? JAMA 2015;313:1089–1091.

    Article  PubMed  Google Scholar 

  5. Cully M. Anticancer drugs: advancing precision medicine in silico. Nat Rev Drug Discov 2015;14:311.

    Article  CAS  PubMed  Google Scholar 

  6. Li SM, Xu H, Chen KJ. The diagnostic criteria of bloodstasis syndrome: considerations for standardization of pattern identification. Chin J Integr Med 2014;20:483–489.

    Article  CAS  PubMed  Google Scholar 

  7. Alraek T. Designing clinical studies that take into account traditional East Asian medicine's systems and methodswith focus on pattern identification. Chin J Integr Med 2014;20:332–335.

    Article  PubMed  Google Scholar 

  8. Birch S, Lewith G. Acupuncture research, the story so far. In MacPherson H, Hammerschlag R, Lewith G, Schnyer R, eds. Acupuncture research: strategies for building an evidence base. London: Elsevier; 2007:15–35.

    Google Scholar 

  9. Lian F, Wu HC, Sun ZG, Guo Y, Shi L, Xue MY. Effects of Liuwei Dihuang Granule on the outcomes of in vitro fertilization pre-embryo transfer in infertility women with Kidney-yin deficiency syndrome and the proteome expressions in the follicular fluid. Chin J Integr Med 2014;20:503–509.

    Article  PubMed  Google Scholar 

  10. Wang Y, Chuo WJ, Li C, Guo SZ, Chen JX, Yu JD, et al. Energy metabolism disorder and myocardial injury in chronic myocardial ischemia with qi deficiency and blood stasis syndrome based on 2-DE proteomics. Chin J Integr Med 2013;19:616–620.

    Article  CAS  PubMed  Google Scholar 

  11. Goto H. Blood stasis syndrome in Japan and its molecular biological analysis. Chin J Integr Med 2014;20:490–495.

    Article  CAS  PubMed  Google Scholar 

  12. Zhao YF, He LY, Liu BY, Li J, Li FY, Huo RL, et al. Syndrome classification based on manifold ranking for viral hepatitis. Chin J Integr Med 2014;20:394–399.

    Article  PubMed  Google Scholar 

  13. Wu DJ, Ye BD, Hu ZP, Shen YP, Shen JP, Lin SY, et al. Bone marrow angiogenesis in patients presenting with differential Chinese medicine syndrome: correlation with the clinico-pathological features of aplastic anemia. Chin J Integr Med 2013;19:905–912.

    Article  CAS  PubMed  Google Scholar 

  14. Liu JF, Zhao MY, Zhuang HZ, Liu C, Weng YB, Li A, et al. Correlation between different Chinese medicine syndromes and changes in microcirculation in septic shock patients. Chin J Integr Med 2013;19:730–735.

    Article  CAS  PubMed  Google Scholar 

  15. Shen ZY, Wang WJ. Reference criteria of deficiency syndrome in Chinese medicine (revised in May 1986). Chin J Integr Tradit West Med (Chin) 1986;6:508.

    Google Scholar 

  16. Liu Q, Su XJ, Yu Y, Liu YL. Correlations among persistent viral infection, heart function and Chinese medicine syndromes in dilated cardiomyopathy patients. Chin J Integr Med 2014;20:928–933.

    Article  PubMed  Google Scholar 

  17. Li JJ, Chen XM, Wei RB. Potential of renal pathology on refining syndrome typing of Chinese medicine in IgA nephropathy. Chin J Integr Med 2013;19:92–97.

    Article  PubMed  Google Scholar 

  18. Liu L, Gao Y, Ma B. Exploring molecular mechanism underlying Chinese medicine syndrome: a study on correlation between Chinese medicine syndrome and biomarkers for ischemic stroke. Chin J Integr Med 2014;20:11–18.

    Article  CAS  PubMed  Google Scholar 

  19. Lu C, Zha Q, Chang A, He Y, Lu A. Pattern differentiation in traditional Chinese medicine can help define specific indications for biomedical therapy in the treatment of rheumatoid arthritis. J Altern Complement Med 2009;15:1021–1025.

    Article  PubMed  Google Scholar 

  20. Jiang M, Zha Q, He Y, Lu A. Risk factors of gastrointestinal and hepatic adverse drug reactions in the treatment of rheumatoid arthritis with biomedical combination therapy and Chinese medicine. J Ethnopharmacol 2012;141:615–621.

    Article  PubMed  Google Scholar 

  21. Shin BC, Kim S, Cho YH. Syndrome pattern and its application in parallel randomized controlled trials. Chin J Integr Med 2013;19:163–171.

    Article  PubMed  Google Scholar 

  22. Lu AP, Bian ZX, Chen KJ. Bridging the traditional Chinese medicine pattern classification and biomedical disease diagnosis with systems biology. Chin J Integr Med 2012;18:883–890.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Graduate School, Beijing University of Chinese Medicine, Beijing, 100029, China

    Jin-gen Li  (李金根)

  2. Cardiovascular Diseases Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China

    Hao Xu  (徐 浩)

Authors
  1. Jin-gen Li  (李金根)
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  2. Hao Xu  (徐 浩)
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Correspondence to Hao Xu  (徐 浩).

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Li, Jg., Xu, H. Incorporating pattern identification of chinese medicine into precision medicine: An integrative model for individualized medicine. Chin. J. Integr. Med. 21, 807–810 (2015). https://doi.org/10.1007/s11655-015-2058-9

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  • DOI: https://doi.org/10.1007/s11655-015-2058-9

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