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A systematic review and quantitative assessment of sleep-disordered breathing during pregnancy and perinatal outcomes

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Abstract

Purpose

Previous investigations have suggested a strong association between sleep-disordered breathing (SDB) during pregnancy and perinatal outcomes. However, the results of the following replication studies were not always concordant. Therefore, this meta-analysis was conducted to evaluate the more reliable estimate.

Methods

A systematic literature search was performed on PubMed, Springer Link, and EMBASE to identify all eligible studies published before August 2013. Summary odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated using fixed or random effects model.

Results

A total of 24 publications met the inclusion criteria and were included in this meta-analysis. Findings demonstrated that moderate-to-severe SDB during pregnancy was associated with gestational diabetes mellitus (OR = 1.78; 95 % CI, 1.29 to 2.46), pregnancy-related hypertension (OR = 2.38; 95 % CI, 1.63 to 3.47), preeclampsia (OR = 2.19; 95 % CI, 1.71 to 2.80), preterm delivery (OR = 1.98; 95 % CI, 1.59 to 2.48), low birth weight (OR = 1.75; 95 % CI, 1.33 to 2.32), neonatal intensive care unit (NICU) admission (OR = 2.43; 95 % CI, 1.61 to 3.68), intrauterine growth restriction (OR = 1.44; 95 % CI, 1.22 to 1.71), and Apgar score of <7 at 1 min (OR = 1.78; 95 % CI, 1.10 to 2.91) based on all studies but not gestational age and birth weight.

Conclusions

This meta-analysis revealed that moderate-to-severe SDB during pregnancy may be associated with most of adverse perinatal outcomes. Further well-designed studies are warranted to confirm our findings.

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Acknowledgments

This research is supported by the Higher Education Department of Anhui Provincial Natural Science Research Project (No. KJ2011A165).

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Correspondence to Shao-Jun Xu.

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Xiu-Xiu Ding and Yi-Le Wu contributed equally to this work.

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Ding, XX., Wu, YL., Xu, SJ. et al. A systematic review and quantitative assessment of sleep-disordered breathing during pregnancy and perinatal outcomes. Sleep Breath 18, 703–713 (2014). https://doi.org/10.1007/s11325-014-0946-4

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  • DOI: https://doi.org/10.1007/s11325-014-0946-4

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