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Hydroxypropyl methylcellulose 2% for dry eye prevention during phacoemulsification in senile and diabetic patients

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Abstract

Purpose

To assess the effect of hydroxypropyl methylcellulose (HPMC) 2% to prevent dry eye during phacoemulsification in senile and diabetic patients.

Methods

This prospective interventional case series comprised 60 eyes (44 patients) with age-related cataract scheduled for standardized phacoemulsification surgery. The patients were assigned to receive either balanced saline solution (BSS, 30 eyes) or HPMC 2% (30 eyes) during surgery. Preoperative and postoperative examinations (1, 3, 7 and 30 days) included measurements of automatic noninvasive tear film breakup time (NITBUT), fluorescein staining, Schirmer I test, tear meniscus height, depth and area and subjective symptoms. Intraoperative application frequency was also assessed.

Results

The mean age of patients was 68.7 ± 2.3 years. The application frequency of BSS during surgery was significantly reduced in HPMC group (P = 0.001). The incidence of dry eye syndrome (DES) was significantly reduced in HPMC group in both senile and diabetic patients. Scores of subjective symptoms were significantly higher in the BSS group in 1 day (P = 0.003) and 3 days (P = 0.043) postoperatively. The first and average NITBUT were significantly higher in HPMC group in 1 day and 3 days after surgery, respectively (P = 0.012 and P = 0.024, respectively). NITBUT values did not significantly change postoperatively in the HPMC group (P > 0.05), while they were significantly lower postoperatively in the BSS group.

Conclusions

Application of HPMC 2% during phacoemulsification reduced the incidence of DES and improved patients’ satisfaction in both senile and diabetic cataract patients. It was also effective in maintaining corneal hydration and was able to significantly reduce the application frequency intraoperatively.

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Acknowledgements

This study was funded by National Natural Science Foundation of China (Grant No. 81371002).

Author information

Author notes

  1. Maierhaba Yusufu and Xin Liu contributed equally to this work and should be considered as equal first authors.

Authors and Affiliations

  1. Department of Ophthalmology, Eye and ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, People’s Republic of China

    Maierhaba Yusufu, Xin Liu, Tianyu Zheng, Fan Fan, Jianjiang Xu & Yi Luo

  2. Key Laboratory of Myopia of State Health Ministry, Shanghai, People’s Republic of China

    Maierhaba Yusufu, Xin Liu, Tianyu Zheng, Jianjiang Xu & Yi Luo

  3. Key Laboratory of Visual Impairment and Restoration of Shanghai, Shanghai, People’s Republic of China

    Xin Liu, Jianjiang Xu & Yi Luo

  4. People’s Hospital of Xinjiang Uygur Autonomous Region, Ürümqi, People’s Republic of China

    Maierhaba Yusufu

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  1. Maierhaba Yusufu
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Correspondence to Yi Luo.

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No author has a financial or proprietary interest in any material or method mentioned.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee of Eye and ENT Hospital of Fudan University and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Yusufu, M., Liu, X., Zheng, T. et al. Hydroxypropyl methylcellulose 2% for dry eye prevention during phacoemulsification in senile and diabetic patients. Int Ophthalmol 38, 1261–1273 (2018). https://doi.org/10.1007/s10792-017-0590-7

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  • DOI: https://doi.org/10.1007/s10792-017-0590-7

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