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A Role of Piperine on Monosodium Urate Crystal-Induced Inflammation—An Experimental Model of Gouty Arthritis

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Abstract

In the present study, the anti-inflammatory effect of piperine was investigated on monosodium urate crystal-induced inflammation in mice, an experimental model for gouty arthritis, and compared it with that of the nonsteroidal anti-inflammatory drug, indomethacin. The levels of lysosomal enzymes, lipid peroxidation, tumor necrosis factor-α, and paw volume were increased significantly, and the activities of antioxidant status were in turn decreased in monosodium urate crystal-induced mice, whereas these changes were reverted to near normal levels upon piperine (30 mg/kg b.wt, i.p.) treatment. In vitro, piperine (50/100 ug/ml) suppressed the level of β-glucuronidase and lactate dehydrogenase in monosodium urate crystal-incubated polymorphonuclear leucocytes in concentration-dependent manner when compared to control cells. Thus, the present study clearly indicated that piperine inhibit the monosodium urate crystal-induced inflammation and can be regarded as therapeutic drug for the treatment of acute gouty arthritis.

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Acknowledgment

The authors would like to express their thanks to Mr. Karthikeyan (Faculty, School of Biosciences and Technology, VIT University, India) for his technical assistance in performing HPLC analysis.

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  1. School of Bio Sciences and Technology, VIT University, Vellore, 632 014, Tamil Nadu, India

    Evan Prince Sabina, Shruthi Nagar & Mahaboobkhan Rasool

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  1. Evan Prince Sabina
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  2. Shruthi Nagar
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  3. Mahaboobkhan Rasool
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Correspondence to Mahaboobkhan Rasool.

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Sabina, E.P., Nagar, S. & Rasool, M. A Role of Piperine on Monosodium Urate Crystal-Induced Inflammation—An Experimental Model of Gouty Arthritis. Inflammation 34, 184–192 (2011). https://doi.org/10.1007/s10753-010-9222-3

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