Skip to main content
SpringerLink
Log in

Cold stress increases resistance to fungal infection throughout life in Drosophila melanogaster

  • Research Article
  • Published:
Biogerontology Aims and scope Submit manuscript

Abstract

Flies were subjected to one of three mild stresses known to have positive effects on longevity (heat, hypergravity, cold), prior to an infection with the entomopathogenic fungus Beauveria bassiana. Flies subjected to cold survived longer to infection, while the other mild stresses had no positive effect. These positive effects of a cold stress on resistance to infection were observed mainly in males and throughout life, i.e., a long time after the cold stress was applied. It was confirmed that cold and hypergravity stresses increased longevity of non-infected flies, but no positive effect of heat shocks were however observed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

References

  • Abete P, Rengo F (2008) Mild stress in the aging heart. In: Le Bourg E, Rattan SIS (eds) Mild stress and healthy aging. Applying hormesis in aging research and therapy. Springer, Dordrecht, pp 139–155

    Chapter  Google Scholar 

  • Abete P, Calabrese E, Ji LL, Kristensen T, Le Bourg E, Loeschcke V, Morris B, Rengo F, Rattan SIS, Safwat A, Sarup P, Sørensen J, Vaiserman AM (2008) Mild stress and healthy aging: perspectives for human beings. In: Le Bourg E, Rattan SIS (eds) Mild stress and healthy aging. Applying hormesis in aging research and therapy. Springer, Dordrecht, pp 171–183

    Chapter  Google Scholar 

  • Burger JMS, Promislow DEL (2004) Sex-specific effects of interventions that extend life span. Sci Aging Knowl Environ 2004(28):pe30

  • Cypser JR, Johnson TE (2002) Multiple stressors in Caenorhabditis elegans induce stress hormesis and extended longevity. J Gerontol Biol Sci 57A:B109–B114

    Google Scholar 

  • Daibo S, Kimura MT, Goto SG (2001) Upregulation of genes belonging to the drosomycin family in diapausing adults of Drosophila triauraria. Gene 278:177–184. doi:10.1016/S0378-1119(01)00713-2

    Article  PubMed  CAS  Google Scholar 

  • Feany MB, Bender WW (2000) A Drosophila model of Parkinson’s disease. Nature 404:394–398. doi:10.1038/35006074

    Article  PubMed  CAS  Google Scholar 

  • Gobert V, Gottar M, Matskevich AA, Rutschmann S, Royet J, Belvin M, Hoffman JA, Ferrandon D (2003) Dual activation of the Drosophila Toll pathway by two pattern recognition factors. Science 302:2126–2130. doi:10.1126/science.1085432

    Article  PubMed  CAS  Google Scholar 

  • Hercus MJ, Loeschcke V, Rattan SIS (2003) Lifespan extension of Drosophila melanogaster through hormesis by repeated mild heat stress. Biogerontology 4:149–156. doi:10.1023/A:1024197806855

    Article  PubMed  CAS  Google Scholar 

  • Holloszy JO, Smith EK (1986) Longevity of cold-exposed rats: a reevaluation of the “rate of living theory”. J Appl Physiol 61:1656–1660

    PubMed  CAS  Google Scholar 

  • Ji LL (2008) Physical activity: a strong stimulant for hormesis during aging. In: Le Bourg E, Rattan SIS (eds) Mild stress and healthy aging. Applying hormesis in aging research and therapy. Springer, Dordrecht, pp 97–114

    Chapter  Google Scholar 

  • Khazaeli AA, Tatar M, Pletcher SD, Curtsinger JW (1997) Heat-induced longevity extension in Drosophila I. Heat treatment, mortality, and thermotolerance. J Gerontol Biol Sci 52A:B48–B52

    Google Scholar 

  • Landis GN, Abdueva D, Skvortsov D, Yang J, Rabin BE, Carrick J, Tavaré S, Tower J (2004) Similar gene expression patterns characterize aging and oxidative stress in Drosophila melanogaster. Proc Natl Acad Sci USA 101:7663–7668. doi:10.1073/pnas.0307605101

    Article  PubMed  CAS  Google Scholar 

  • Le Bourg E (2005) Hormetic protection of Drosophila melanogaster middle-aged male flies from heat stress by mildly stressing them at young age. Naturwissenschaft 92:293–296. doi:10.1007/s00114-005-0627-z

    Article  CAS  Google Scholar 

  • Le Bourg E (2007) Hormetic effects of repeated exposures to cold at young age on longevity, aging and resistance to heat or cold shocks in Drosophila melanogaster. Biogerontology 8:431–444. doi:10.1007/s10522-007-9086-6

    Article  PubMed  Google Scholar 

  • Le Bourg E (2008a) Three mild stresses known to increase longevity in Drosophila melanogaster flies do not increase resistance to oxidative stress. Am J Pharm Toxicol 3:134–140

    Article  Google Scholar 

  • Le Bourg E (2008b) Hypergravity in Drosophila melanogaster. In: Le Bourg E, Rattan SIS (eds) Mild stress and healthy aging. Applying hormesis in aging research and therapy. Springer, Dordrecht, pp 43–63

    Chapter  Google Scholar 

  • Le Bourg E, Minois N (1997) Increased longevity and resistance to heat shock in Drosophila melanogaster flies exposed to hypergravity. C R Acad Sci Paris 320:215–221

    PubMed  CAS  Google Scholar 

  • Le Bourg E, Minois N (1999) A mild stress, hypergravity exposure, postpones behavioral aging in Drosophila melanogaster. Exp Gerontol 34:157–172. doi:10.1016/S0531-5565(98)00077-1

    Article  PubMed  CAS  Google Scholar 

  • Le Bourg E, Fournier D (2004) Is lifespan extension accompanied by improved antioxidant defences? A study of superoxide dismutase and catalase in Drosophila melanogaster flies that lived in hypergravity at young age. Biogerontology 5:261–266. doi:10.1023/B:BGEN.0000038046.37590.03

    Article  PubMed  CAS  Google Scholar 

  • Le Bourg E, Rattan SIS (eds) (2008) Mild stress and healthy aging. Applying hormesis in aging research and therapy. Springer, Dordrecht

  • Le Bourg E, Minois N, Bullens P, Baret P (2000) A mild stress due to hypergravity exposure at young age increases longevity in Drosophila melanogaster males. Biogerontology 1:145–155. doi:10.1023/A:1010043914016

    Article  PubMed  CAS  Google Scholar 

  • Le Bourg E, Valenti P, Lucchetta P, Payre F (2001) Effects of mild heat shocks at young age on aging and longevity in Drosophila melanogaster. Biogerontology 2:155–164. doi:10.1023/A:1011561107055

    Article  PubMed  CAS  Google Scholar 

  • Le Bourg E, Valenti P, Payre F (2002) Lack of hypergravity-associated longevity extension in Drosophila melanogaster flies overexpressing hsp70. Biogerontology 3:355–364. doi:10.1023/A:1021367800170

    Article  PubMed  CAS  Google Scholar 

  • Le Bourg E, Toffin E, Massé A (2004) Male Drosophila melanogaster flies exposed to hypergravity at young age are protected against a non-lethal heat shock at middle age but not against behavioral impairments due to this shock. Biogerontology 5:431–443. doi:10.1007/s10522-004-3200-9

    Article  PubMed  Google Scholar 

  • Lemaître B, Reichardt JM, Hoffmann JA (1997) Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms. Proc Natl Acad Sci USA 94:14614–14619. doi:10.1073/pnas.94.26.14614

    Article  PubMed  Google Scholar 

  • Libert S, Chao Y, Zwiener J, Pletcher SD (2008) Realized immune response is enhanced in long-lived puc and chico mutants but is unaffected by dietary restriction. Mol Immunol 45:810–817. doi:10.1016/j.molimm.2007.06.353

    Article  PubMed  CAS  Google Scholar 

  • Martinelli C, Reichhardt JM (2005) Evolution and integration of innate immune systems from flies to humans: lessons and questions. J Endotoxin Res 11:243–248

    PubMed  CAS  Google Scholar 

  • Minois N, Le Bourg E (1999) Resistance to stress as a function of age in Drosophila melanogaster living in hypergravity. Mech Ageing Dev 109:53–64. doi:10.1016/S0047-6374(99)00025-1

    Article  PubMed  CAS  Google Scholar 

  • Minois N, Rattan SIS (2003) Hormesis in aging and longevity. In: Rattan SIS (ed) Modulating aging and longevity. Kluwer, Dordrecht, pp 127–137

    Google Scholar 

  • Miquel J, Lundgren PR, Binnard R (1972) Negative geotaxis and mating behavior in control and gamma-irradiated Drosophila. Drosoph Inf Serv 60:48

    Google Scholar 

  • Pletcher SD, Macdonald SJ, Marguerie R, Certa U, Stearns SC, Goldstein DB, Partridge L (2002) Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster. Curr Biol 12:712–723. doi:10.1016/S0960-9822(02)00808-4

    Article  PubMed  CAS  Google Scholar 

  • Ren C, Webster P, Finkel SE, Tower J (2007) Increased internal and external bacterial load during Drosophila aging without life-span trade-off. Cell Metab 6:144–152. doi:10.1016/j.cmet.2007.06.006

    Article  PubMed  CAS  Google Scholar 

  • Rutschmann S, Jung AC, Hetru C, Reichhart JM, Hoffmann JA, Ferrandon D (2000) The Rel protein DIF mediates the antifungal but not the antibacterial host defense in Drosophila. Immunity 12:569–580. doi:10.1016/S1074-7613(00)80208-3

    Article  PubMed  CAS  Google Scholar 

  • Sacher GA (1963) Effects of X-rays on the survival of Drosophila imagoes. Physiol Zool 36:295–311

    Google Scholar 

  • Sørensen JG, Kristensen TN, Kristensen KV, Loeschcke V (2007) Sex specific effects of heat induced hormesis in Hsf-deficient Drosophila melanogaster. Exp Gerontol 42:1123–1129. doi:10.1016/j.exger.2007.09.001

    Article  PubMed  CAS  Google Scholar 

  • Vaiserman AM, Koshel NM, Litoshenko AY, Mozzhukina TG, Voitenko VP (2003) Effects of X-irradiation in early ontogenesis on the longevity and amount of the S1 nuclease-sensitive DNA sites in adult Drosophila melanogaster. Biogerontology 4:9–14. doi:10.1023/A:1022460817227

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Centre de Recherche sur la Cognition Animale, UMR CNRS 5169, Université Paul-Sabatier, 118 route de Narbonne, Toulouse Cedex 9, 31062, France

    Éric Le Bourg & Isabelle Massou

  2. Centre de Biologie du Développement, UMR CNRS 5547, Université Paul-Sabatier, 118 route de Narbonne, Toulouse Cedex 9, 31062, France

    Vanessa Gobert

Authors
  1. Éric Le Bourg
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Isabelle Massou
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Vanessa Gobert
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Éric Le Bourg.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Le Bourg, É., Massou, I. & Gobert, V. Cold stress increases resistance to fungal infection throughout life in Drosophila melanogaster . Biogerontology 10, 613–625 (2009). https://doi.org/10.1007/s10522-008-9206-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10522-008-9206-y

Keywords

Search

Navigation