Abstract
Purpose
To examine the possible prognostic factors in patients with penile cancer after surgical management and to identify the independent predictive factors of the prognosis.
Materials and methods
Clinical data of 135 patients with penile cancer who underwent surgical management in two medical centers were collected. Follow-up data were available for 103 patients. Possible prognostic factors including patient’s age; smoking or not; course of disease; phimosis or not; type of surgery; tumor stage; nodal stage; tumor grade and pathological lymph nodes metastasis were retrospectively analyzed by univariate and multivariate analyses with Cox regression.
Results
Five-year cancer-specific survival (CSS) and 1-year CSS were 88.5 and 98.1%, respectively. Univariate Cox analysis revealed that nodal stage and pathological lymph nodes metastasis were significant prognostic factors. Multivariate Cox analysis revealed pathological lymph nodes metastasis was the independent predictive factor of the prognosis.
Conclusion
Pathological lymph nodes metastasis is the independent predictive factor worsening the prognosis in patients with penile cancer.
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References
Hakenberg OW, Comperat EM, Minhas S et al (2015) EAU guidelines on penile cancer: 2014 update. Eur Urol 67:142–150
Velazquez EF, Cubilla AF (2007) Penile squamous cell carcinoma. Anatomic, pathologic and viral studies in Paraguay (1993–2007). Anal Quant Cytol Histol 29:185–198
Daling JR, Madeleine MM, Johnson LG et al (2005) Penile cancer: importance of circumcision, human papillomavirus and smoking for in situ and invasive disease. Int J Cancer 116:606–616
Wiechno P, Kalinowski T, Itrych B et al (2014) Prognostic factors in patients undergoing lymphadenectomy for squamous cell carcinoma of the penis. Urol Int 92:194–201
Hegarty PK, Eardley I, Heidenreich A et al (2014) Penile cancer: organ-sparing techniques. BJU Int 114:799–805
Aita GA, Zequi SC, Costa WH et al (2016) Tumor histologic grade is the most important prognostic factor in patients with penile cancer and clinically negative lymph nodes not submitted to regional lymphadenectomy. Int Braz J Urol 42:1136–1143
Pizzocaro G, Algaba F, Horenblas S et al (2010) European Association of Urology (EAU) Guidelines Group on Penile Cancer. EAU penile cancer guidelines 2009. Eur Urol 57:1002–1012
Sobin LH, Gospodarowicz MK, Wittekind C (eds) (2009) The TNM classification of malignant tumors, 7th edn. International Union Against Cancer, Wiley-Blackwell, Hoboken
Velazquez EF, Ayala G, Liu H et al (2008) Histologic grade and perineural invasion are more important than tumor thickness as predictor of nodal metastasis in penile squamous cell carcinoma invading 5 to 10 mm. Am J Surg Pathol 32:974–979
Pettaway C, Lance R, Davis J (2012) Tumors of the penis. In: Wein AJ, Kavoussi LR, Novick AC (eds) Campbell-Walsh urology, 10th edn. WB Saunders, St. Louis
Bhagat SK, Gopalakrishnan G, Kekre NS et al (2010) Factors predicting inguinal node metastasis in squamous cell cancer of penis. World J Urol 28:93–98
Ficarra V, Akduman B, Bouchot O et al (2010) Prognostic factors in penile cancer. Urology 76:S66e73
Ma C, Zhou Y, Zhou S et al (2017) Preoperative peripheral plasma fibrinogen level is an independent prognostic marker in penile cancer. Oncotarget 8:12355–12363
Kasuga J, Kawahara T, Takamoto D et al (2016) Increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer. BMC Cancer 16:396
Alkatout I, Naumann CM, Hedderich J et al (2011) Squamous cell carcinoma of the penis: predicting nodal metastases by histologic grade, pattern of invasion and clinical examination. Urol Oncol 29:774–781
Aita G, da Costa WH, de Cassio Zequi S et al (2015) Pattern of invasion is the most important prognostic factor in patients with penile cancer submitted to lymph node dissection and pathological absence of lymph node metastasis. BJU Int 116:584–589
Li ZS, Yao K, Chen P et al (2014) Disease-specific survival after radical lymphadenectomy for penile cancer: prediction by lymph node count and density. Urol Oncol 32:893–900
Leijte JA, Valdes Olmos RA, Nieweg OE et al (2008) Anatomical mapping of lymphatic drainage in penile carcinoma with SPECT-CT: implications for the extent of inguinal lymph node dissection. Eur Urol 54:885–890
Guimarães GC, Lopes A, Campos RS et al (2006) Front pattern of invasion in squamous cell carcinoma of the penis: new prognostic factor for predicting risk of lymph node metastases. Urology 68:148–153
Chipollini J, Tang DH, Manimala N et al (2018) Evaluating the accuracy of intraoperative frozen section during inguinal lymph node dissection in penile cancer. Urol Oncol 36:14.e1–14.e5
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Shuguang Wen, Wenbiao Ren and Xiongbing Zu conceived and designed the study; Shuguang Wen, Wenbiao Ren, Bichen Xue and Yongjun Jiang performed the study; Yi Fan, Chunming Zeng and Yujia Li analyzed the data; all the authors wrote the article. All authors have read and approved the final manuscript.
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The authors have no conflict of interest to declare.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
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Informed consent was obtained from all individual participants included in the study.
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Wen, S., Ren, W., Xue, B. et al. Prognostic factors in patients with penile cancer after surgical management. World J Urol 36, 435–440 (2018). https://doi.org/10.1007/s00345-017-2167-5
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DOI: https://doi.org/10.1007/s00345-017-2167-5