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The human FK506-binding proteins: characterization of human FKBP19

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Abstract

Analysis of the human repertoire of the FK506-binding protein (FKBP) family of peptidyl-prolyl cis/trans isomerases has identified an expansion of genes that code for human FKBPs in the secretory pathway. There are distinct differences in tissue distribution and expression levels of each variant. In this article we describe the characterization of human FKBP19 (Entrez Gene ID: FKBP11), an FK506-binding protein predominantly expressed in vertebrate secretory tissues. The FKBP19 sequence comprises a cleavable N-terminal signal sequence followed by a putative peptidyl-prolyl cis/trans isomerase domain with homology to FKBP12. This domain binds FK506 weakly in vitro. FKBP19 mRNA is abundant in human pancreas and other secretory tissues and high levels of FKBP19 protein are detected in the acinar cells of mouse pancreas.

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Acknowledgments

This project was funded by a BBSRC CASE award sponsored by Pfizer Global Research and Development, Sandwich, UK. The authors thank Dr. Valerie Lucas and Richard Bazin at Pfizer UK for their assistance.

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Authors and Affiliations

  1. Trafford Centre for Graduate Medical Education and Research, University of Sussex, Falmer, Brighton, BN1 9QG, UK

    Stuart L. Rulten

  2. Discovery Biology Department, Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK

    Ross A. Kinloch, Colin Robinson & Lucy Gettins

  3. MRC Mammalian Genetics Unit, Harwell, Oxfordshire, OX11 0RD, UK

    Hilda Tateossian

  4. Brighton and Sussex Medical School, Falmer, Brighton, BN1 9PX, UK

    John E. Kay

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  1. Stuart L. Rulten
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  2. Ross A. Kinloch
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  3. Hilda Tateossian
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  4. Colin Robinson
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  5. Lucy Gettins
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  6. John E. Kay
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Correspondence to Stuart L. Rulten.

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Rulten, S.L., Kinloch, R.A., Tateossian, H. et al. The human FK506-binding proteins: characterization of human FKBP19. Mamm Genome 17, 322–331 (2006). https://doi.org/10.1007/s00335-005-0127-7

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  • DOI: https://doi.org/10.1007/s00335-005-0127-7

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