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Gastric hepatoid adenocarcinoma: CT findings

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Abstract

Background

In this study, we evaluated the CT findings of patients with hepatoid adenocarcinoma of the stomach.

Methods

The CT scans of eight patients (seven males and one female; age range 44–70 years; mean age 59 years) with histologically proven hepatoid adenocarcinoma of the stomach were retrospectively evaluated by two radiologists in consensus. Scans were evaluated for gastric wall thickening, involved site enhancement, adjacent organ invasion, lymphadenopathy, distant metastases, and venous tumor thrombosis.

Results

Tumors appeared as eccentric wall thickening (n = 8) and heterogeneous enhancement (n = 7). Adjacent organ invasions were noted to liver (n = 3), pancreas (n = 2), and esophagus (n = 1). All eight patients had a regional lymphadenopathy larger than 8 mm in its short axis. Distant metastases (liver, n = 4; non-regional lymph node, n = 1) were also noted. Venous tumor thrombosis was identified in the portal vein (n = 3), splenic vein (n = 1), main portal vein (n = 1), or right gastroepiploic vein (n = 1) in the regions near primary gastric tumors or metastatic masses.

Conclusion

On CT scans, hepatoid adenocarcinoma of the stomach appears as an eccentric gastric wall thickening and shows a strong tendency for liver and lymph node metastasis and venous invasion around the primary gastric tumor or a metastatic hepatic mass.

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References

  1. Terracciano LM, Glatz K, Mhawech P, et al. (2003) Hepatoid adenocarcinoma with liver metastasis mimicking hepatocellular carcinoma: an immunohistochemical and molecular study of eight cases. Am J Surg Pathol 27:1302–1312

    Article  PubMed  Google Scholar 

  2. Genova S, Dikov D, Peshev Z, et al. (2003) Hepatoid adenocarcinoma of the lung: a case report. Khirurgiia (Sofiia) 59:45–47

    CAS  Google Scholar 

  3. Lopez-Beltran A, Luque RJ, Quintero A, et al. (2003) Hepatoid adenocarcinoma of the urinary bladder. Virchows Arch 442:381–387

    PubMed  CAS  Google Scholar 

  4. Takano M, Shibasaki T, Sato K, et al. (2003) Malignant mixed Mullerian tumor of the uterine corpus with alpha-fetoprotein-producing hepatoid adenocarcinoma component. Gynecol Oncol 91:444–448

    Article  PubMed  Google Scholar 

  5. Hughes K, Kelty S, Martin R (2004) Hepatoid carcinoma of the pancreas. Am Surg 70:1030–1033

    PubMed  Google Scholar 

  6. Sockeel P, Abbey-Toby A, Regimbeau JM, et al. (2004) Hepatoid adenocarcinoma of the lower esophagus. Gastroenterol Clin Biol 28:84–86

    Article  PubMed  Google Scholar 

  7. Tsung JS, Yang PS (2004) Hepatoid carcinoma of the ovary: characteristics of its immunoreactivity. A case report. Eur J Gynaecol Oncol 25:745–748

    PubMed  CAS  Google Scholar 

  8. Jalle T, Gerard C, Lada PE, et al. (2005) Hepatoid adenocarcinoma of the stomach. A case report. Ann Chir 131(3):213–215

    Article  PubMed  Google Scholar 

  9. Sakamoto K, Kimura N, Tokumura H, et al. (2005) Hepatoid adenocarcinoma of the gallbladder. Histopathology 47:649–651

    Article  PubMed  CAS  Google Scholar 

  10. Zhang J, Li XJ, Teng HH (2005) Colon hepatoid adenocarcinoma with live metastasis. Zhonghua Bing Li Xue Za Zhi 34:249–250

    PubMed  Google Scholar 

  11. Ishikura H, Fukasawa Y, Ogasawara K, et al. (1985) An AFP-producing gastric carcinoma with features of hepatic differentiation. A case report. Cancer 56:840–848

    Article  PubMed  CAS  Google Scholar 

  12. Nagai E, Ueyama T, Yao T, et al. (1993) Hepatoid adenocarcinoma of the stomach. A clinicopathologic and immunohistochemical analysis. Cancer 72:1827–1835

    Article  PubMed  CAS  Google Scholar 

  13. Araki T, Suda K, Sekikawa T, et al. (1990) Portal venous tumor thrombosis associated with gastric adenocarcinoma. Radiology 174:811–814

    PubMed  CAS  Google Scholar 

  14. Inagawa S, Shimazaki J, Hori M, et al. (2001) Hepatoid adenocarcinoma of the stomach. Gastric Cancer 4:43–52

    Article  PubMed  CAS  Google Scholar 

  15. Sohn KM, Lee JM, Lee SY, et al. (2000) Comparing MR imaging and CT in the staging of gastric carcinoma. AJR Am J Roentgenol 174:1551–1557

    PubMed  CAS  Google Scholar 

  16. Kim AY, Kim HJ, Ha HK (2005) Gastric cancer by multidetector row CT: preoperative staging. Abdom Imaging 30:465–472

    Article  PubMed  CAS  Google Scholar 

  17. Dorfman RE, Alpern MB, Gross BH, et al. (1991) Upper abdominal lymph nodes: criteria for normal size determined with CT. Radiology 180:319–322

    PubMed  CAS  Google Scholar 

  18. Kim HJ, Kim AY, Oh ST, et al. (2005) Gastric cancer staging at multi-detector row CT gastrography: comparison of transverse and volumetric CT scanning. Radiology 236:879–885

    Article  PubMed  Google Scholar 

  19. Ishikawa M, Koyama S, Ikegami T, et al. (1995) Venous tumor thrombosis and cavernous transformation of the portal vein in a patient with gastric carcinoma. J Gastroenterol 30:529–533

    Article  PubMed  CAS  Google Scholar 

  20. Tublin ME, Dodd GD III, Baron RL (1997) Benign and malignant portal vein thrombosis: differentiation by CT characteristics. AJR Am J Roentgenol 168:719–723

    PubMed  CAS  Google Scholar 

  21. D’Elia F, Zingarelli A, Palli D, et al. (2000) Hydro-dynamic CT preoperative staging of gastric cancer: correlation with pathological findings. A prospective study of 107 cases. Eur Radiol 10:1877–1885

    Article  PubMed  CAS  Google Scholar 

  22. Roberts CC, Colby TV, Batts KP (1997) Carcinoma of the stomach with hepatocyte differentiation (hepatoid adenocarcinoma). Mayo Clin Proc 72:1154–1160

    Article  PubMed  CAS  Google Scholar 

  23. Trompetas V, Varsamidakis N, Frangia K, et al. (2003) Gastric hepatoid adenocarcinoma and familial investigation: does it always produce alpha-fetoprotein? Eur J Gastroenterol Hepatol 15:1241–1244

    Article  PubMed  Google Scholar 

  24. Tanaka A, Takeda R, Mukaihara S, et al. (2002) Tumor thrombi in the portal vein system originating from gastrointestinal tract cancer. J Gastroenterol 37:220–228

    Article  PubMed  Google Scholar 

  25. Ishikura H, Kishimoto T, Andachi H, et al. (1997) Gastrointestinal hepatoid adenocarcinoma: venous permeation and mimicry of hepatocellular carcinoma, a report of four cases. Histopathology 31:47–54

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Jae Young Lee.

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Lee, M.W., Lee, J.Y., Kim, Y.J. et al. Gastric hepatoid adenocarcinoma: CT findings. Abdom Imaging 32, 293–298 (2007). https://doi.org/10.1007/s00261-006-9073-4

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