Abstract
Near-infrared spectroscopy (NIRS) has been used to measure changes in cerebral oxy- and deoxy- haemoglobin (δ[HbO2], δ[HHb]) in response to functional activation. It has been previously reported that during functional activation of the motor cortex heart rate increases. The aim of this study was to investigate systemic changes during functional activation of the frontal cortex. The responses to anagram presentations with varying difficulty (4-Letters and 7-Letters) over a 6 minute period were recorded. A Hamamatsu NIRO 200 NIRS system recorded δ[HbO2] and δ[HHb] using the modified Beer Lambert law (MBL) and tissue oxygenation index (TOI) employing spatial resolved spectroscopy (SRS) over the left and right frontal hemisphere. Mean blood pressure (MBP) and heart rate (HR) were measured continuously. Nine young healthy volunteers (mean age 23) were included in the analysis. Significant task related changes were observed in both the NIRS and systemic signals during the anagram solving with increases in [HbO2] and [HHb] accompanied by changes in MBP and HR. The [HbO2] and [HHb] signals measured over the frontal region were found to have a varying association with the MBP signal across different volunteers. The effect of these systemic changes on measured NIRS signals must be considered
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
H. Obrig, A. Villringer “Beyond the visible-imaging the human brain with light” J. Cereb. Blood Flow Metab. 23, 1–18 (2003).
T. Leung, C.E. Elwell, J. Henty, D.T. Delpy “Simultaneous measurement of cerebral tissue oxygenation over the adult frontal and motor cortex during rest and functional activation” Adv. Exp. Med & Biol 530, 385–389 (2002).
J. Fallgater, W. Strik “Frontal brain activation during the Wiscosin Card Sorting Test assessed with two channel near-infrared spectroscopy” Eur. Arch. Psychiatry Clin. Neurosci. 248, 245–249 (1998).
M.J. Hermann, A.C. Ehlis, A.J. Fallgater “Prefrontal activation through task requirements of emotional induction measured with NIRS” Biol. Psychol. 64, 255–263 (2003).
Y. Hoshi, B.H. Tsou, V.A. Billock, M. Tanosaki, Y. Iguchi, M. Shimada, T. Shinba, Y. Yamada, I. Oda “Spatiotemporal characteristics of hemodynamic changes in the human lateral prefrontal cortex during working memory tasks” Neuroimage 20, 1493–1504 (2003).
A. Duncan, J. Meek, M. Clemence, C.E. Elwell, L. Tyszczuk, M. Cope, D.T. Delpy “Optical pathlength measurements on adult head, calf and forearm and the head of the newborn infant using phase resolved optical spectroscopy” Phys. Med. Biol. 40, 295–304 (1995).
B. Chance, S. Nioka, S. Sadi, C. Li “Oxygenation and blood concentration changes in human subjects prefrontal activation by anagram solutions” Adv. Exp. Med. & Biol. 510,397–401 (2003).
H. Obrig, M. Neufang, R. Wenzel, M. Kohl, J. Steinbrink, K. Einhaupl, A. Villringer “Spontaneous low frequency oscillations of cerebral hemodynamics and metabolism in human adults” Neuroimage 12, 623–639 (2000).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer Science+Business Media, LLC
About this paper
Cite this paper
Tachtsidis, I., Leung, T.S., Devoto, L., Delpy, D.T., Elwell, C.E. (2008). Measurement of Frontal Lobe Functional Activation and Related Systemic Effects: A Near-Infrared Spectroscopy Investigation. In: Kang, K.A., Harrison, D.K., Bruley, D.F. (eds) Oxygen Transport to Tissue XXIX. Advances In Experimental Medicine And Biology, vol 614. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-74911-2_44
Download citation
DOI: https://doi.org/10.1007/978-0-387-74911-2_44
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-74910-5
Online ISBN: 978-0-387-74911-2
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)