Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Paracetamol treatment of patent ductus arteriosus in preterm infants

Journal of Perinatology volume 34, pages 748–749 (2014)Cite this article

Subjects

Abstract

Objective:

To determine the effectiveness of paracetamol in closing patent ductus arteriosus (PDA) in preterm infants of our population.

Study Design:

Infants with symptomatic PDA who failed or could not get ibuprofen treatment, and who were candidates for surgical ligation, were administered oral paracetamol 15 mgkg–1 every 6h, for up to 7 days and were monitored for clinical, echocardiographic and laboratorial courses.

Result:

Seven infants, between 24–27 weeks’ gestation, were included. In four the DA was closed while treated by paracetamol—in one of them the DA reopened, treated with paracetamol again, and closed. In one infant, the DA almost closed, symptoms disappeared, and the DA subsequently closed spontaneously later. Two needed surgical ligation. There were no hematologic or biochemical abnormalities.

Conclusion:

Although there is the possibility that PDA may have closed spontaneously, it is proposed that paracetamol could contribute to the closure of PDA in preterm infants.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Hammerman C, Bin-Nun A, Markovitch E, Schimmel MS, Kaplan M, Fink D . Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics 2011; 128 (6): e1618–e1621.

    Article  Google Scholar 

  2. Yurttutan S, Oncel MY, Arayici S, Uras N, Altug N, Erdeve O et al. A different first-choice drug in the medical management of patent ductus arteriosus: oral paracetamol. J Matern Fetal Neonatal Med 2013; 26 (8): 825–827.

    Article  CAS  Google Scholar 

  3. Oncel MY, Yurttutan S, Degirmencioglu H, Uras N, Altug N, Erdeve O et al. Intravenous paracetamol treatment in the management of patent ductus arteriosus in extremely low birth weight infants. Neonatology 2013; 103 (3): 166–169.

    Article  CAS  Google Scholar 

  4. Alan S, Kahvecioglu D, Erdeve O, Atasay B, Arsan S . Is Paracetamol a Useful Treatment for Ibuprofen-Resistant Patent Ductus Arteriosus? Concerning the Article by M.Y. Oncel et al.: Intravenous Paracetamol Treatment in the Management of Patent Ductus Arteriosus in Extremely Low Birth Weight Infants [Neonatology 2013;103:166–169]. Neonatology 2013; 104 (3): 168–169.

    Article  Google Scholar 

  5. Özmert MA, Özdemir OM, Doğan M, Küçüktaşçi K, Ergin H, Şahin Ö . Paracetamol therapy for patent ductus arteriosus in premature infants: a chance before surgical ligation. Pediatr Cardiol 2013; 35 (2): 276–279.

    Google Scholar 

  6. Sinha R, Negi V, Dalal SS . An interesting observation of PDA closure with oral paracetamol in preterm neonates. J Clin Neonatol 2013; 2 (1): 30–32.

    Article  Google Scholar 

Download references

Acknowledgements

We thank Esther Eshkol for editorial assistance.

Author information

Authors and Affiliations

  1. Department of Neonatology, Hillel Yaffe Medical Center, Hadera, Israel,

    E Nadir, S Foldi, A Hochberg & M Feldman

  2. Unit of Pediatric Cardiology, Hillel Yaffe Medical Center, Hadera, Israel,

    E Kassem

Authors
  1. E Nadir
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E Kassem
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S Foldi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A Hochberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M Feldman
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to E Nadir.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Nadir, E., Kassem, E., Foldi, S. et al. Paracetamol treatment of patent ductus arteriosus in preterm infants. J Perinatol 34, 748–749 (2014). https://doi.org/10.1038/jp.2014.96

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/jp.2014.96

This article is cited by

Search

Advanced search

Quick links