Prevalence of Nasopharyngeal Carriage, Serotype Distribution, and Antimicrobial Resistance of Streptococcus pneumoniae among Children with Chronic Diseases

Serdar Pekuz; Ahmet Soysal; Gulsen Akkoc; Serkan Atıcı; Nurhayat Yakut; Gulsen Altınkanat Gelmez; Eda Kepenekli Kadayifci; Deniz Güneser; Sevliya Ocal Demir; Guner Söyletir; Mustafa Bakır

doi:10.7883/yoken.JJID.2017.410

Original Article

Prevalence of Nasopharyngeal Carriage, Serotype Distribution, and Antimicrobial Resistance of Streptococcus pneumoniae among Children with Chronic Diseases

Serdar Pekuz, Ahmet Soysal, Gulsen Akkoc, Serkan Atıcı, Nurhayat Yakut, Gulsen Altınkanat Gelmez, Eda Kepenekli Kadayifci, Deniz Güneser, Sevliya Ocal Demir, Guner Söyletir, Mustafa Bakır

Author information

Serdar Pekuz
Sanlıurfa Training and Research Hospital, Clinics of Pediatrics
Ahmet Soysal
Atasehir Memorial Hospital, Clinics of Pediatrics
Gulsen Akkoc
T.C. Sağlık Bakanlığı-Marmara University Pendik Training and Research Hospital, Clinic of Pediatric Infectious Diseases
Serkan Atıcı
Ersoy Hospital
Nurhayat Yakut
T.C. Sağlık Bakanlığı-Marmara University Pendik Training and Research Hospital, Clinic of Pediatric Infectious Diseases
Gulsen Altınkanat Gelmez
Department of Microbiology, Pendik
Eda Kepenekli Kadayifci
T.C. Sağlık Bakanlığı-Marmara University Pendik Training and Research Hospital, Clinic of Pediatric Infectious Diseases
Deniz Güneser
Department of Microbiology, Pendik
Sevliya Ocal Demir
T.C. Sağlık Bakanlığı-Marmara University Pendik Training and Research Hospital, Clinic of Pediatric Infectious Diseases
Guner Söyletir
Department of Microbiology, Pendik
Mustafa Bakır
Department of Microbiology, Pendik

Keywords: Streptococcus pneumoniae, nasopharyngeal carriage, children with chronic diseases, pneumococcal vaccines

JOURNAL FREE ACCESS

2019 Volume 72 Issue 1 Pages 7-13

DOI https://doi.org/10.7883/yoken.JJID.2017.410

Browse “Advance online publication” version

Details

Abstract

The aim of this study was to evaluate the prevalence of nasopharyngeal (NP) carriage and the serotype distribution and antimicrobial resistance of Streptococcus pneumoniae in children with chronic diseases, which predisposes them to invasive pneumococcal disease in comparison with that in healthy children. A cross-sectional prevalence study was performed between February 2015 and February 2016 in Istanbul, Turkey. We enrolled 1,024 children with chronic diseases and 394 healthy children aged 0–18 years. The overall prevalence of S. pneumoniae NP (SPNP) carriage was 9.8%, with 8.4% in healthy children and 10.3% in children with chronic diseases. The prevalence rates of SPNP carriage were 17.5%, 13.5%, 10.5%, 9.3%, 8.6%, 8.6%, 8%, 6.7%, and 4%, respectively, in each of the following risk groups: primary immunodeficiency, asthma, chronic renal failure, congenital heart disease, chronic lung disease, leukemia, nephrotic syndrome, solid organ tumors, and type 1 diabetes mellitus. In the multivariate analysis, a history of otitis media within the last year, a history of pneumonia within the last year, and more than one sibling under 8 years of age were found to be independent risk factors for SPNP carriage.

Corresponding author

Register with J-STAGE for free!