Dynamic Constitution of the Pathogens Inducing Encephalitis in Hand, Foot and Mouth Disease in Kunming, 2009–2011

Shaohui Ma; Ying Zhang; Cengqing Du; Ting Yang; Qiong Liu; Yue Pan; Junying Chen; Haijing Shi; Qiangming Sun; Longding Liu; Qihan Li

doi:10.7883/yoken.JJID.2014.428

Original Article

Dynamic Constitution of the Pathogens Inducing Encephalitis in Hand, Foot and Mouth Disease in Kunming, 2009–2011

Shaohui Ma, Ying Zhang, Cengqing Du, Ting Yang, Qiong Liu, Yue Pan, Junying Chen, Haijing Shi, Qiangming Sun, Longding Liu, Qihan Li

Author information

Shaohui Ma
Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Disease, Institute of Medical Biology, Chinese Academy of Medicine Sciences and Peking Union Medical College
Ying Zhang
Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Disease, Institute of Medical Biology, Chinese Academy of Medicine Sciences and Peking Union Medical College
Cengqing Du
Department of Infectious Diseases of Kunming Children's Hospital
Ting Yang
Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Disease, Institute of Medical Biology, Chinese Academy of Medicine Sciences and Peking Union Medical College
Qiong Liu
Department of Infectious Diseases of Kunming Children's Hospital
Yue Pan
Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Disease, Institute of Medical Biology, Chinese Academy of Medicine Sciences and Peking Union Medical College
Junying Chen
Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Disease, Institute of Medical Biology, Chinese Academy of Medicine Sciences and Peking Union Medical College
Haijing Shi
Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Disease, Institute of Medical Biology, Chinese Academy of Medicine Sciences and Peking Union Medical College
Qiangming Sun
Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Disease, Institute of Medical Biology, Chinese Academy of Medicine Sciences and Peking Union Medical College
Longding Liu
Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Disease, Institute of Medical Biology, Chinese Academy of Medicine Sciences and Peking Union Medical College
Qihan Li
Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Disease, Institute of Medical Biology, Chinese Academy of Medicine Sciences and Peking Union Medical College

Keywords: hand, foot and mouth disease, enterovirus 71, coxsackievirus A 16, echovirus 9

JOURNAL FREE ACCESS

2015 Volume 68 Issue 6 Pages 504-510

DOI https://doi.org/10.7883/yoken.JJID.2014.428

Browse “Advance online publication” version

Details

Abstract

Hand, foot and mouth disease (HFMD), caused by various viral pathogens, is an emerging infectious disease in children in Asia. Understanding the composition of these pathogens is necessary to prevent and control this disease. In the present study, the pathogens in 436 HFMD patients (from 2009 to 2011) with concurrent clinical indications of encephalitis, meningoencephalitis, or both, were defined using the semi-nested PCR. A systematic analysis of the composition of these pathogens was performed. Various enteroviruses that are capable of inducing central nervous system (CNS) damage in HFMD patients were identified, including enterovirus 71, coxsackievirus A16, and Echovirus 9. Most of these pathogens were found co-infecting the patients. The composition of the pathogens that induced CNS damage in the HFMD patients was dynamically modulated in the cases.

Corresponding author

Register with J-STAGE for free!